DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCAP-R and gpr39

DIOPT Version :9

Sequence 1:	NP_001368957.1	Gene:	CCAP-R / 2768688	FlyBaseID:	FBgn0039396	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_956711.1	Gene:	gpr39 / 791773	ZFINID:	ZDB-GENE-040426-1395	Length:	440	Species:	Danio rerio

Alignment Length:	406	Identity:	106/406 - (26%)
Similarity:	174/406 - (42%)	Gaps:	88/406 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 LWILFTVI----VLGNSAVLFV-MFINKN---RKSRMNYFIKQLALADLCVGLLNV---LTDIIW 183
            |.:|:.:|    ||||||.:.| ..:.:|   ::|...:.: .||.:||.|.|:.:   |...||
Zfish    23 LTVLYCLILSLGVLGNSATIHVAQVLQRNGYLQRSVAEHMV-SLACSDLLVLLIGLPVELYSAIW 86

  Fly   184 RITISWRAGNLACKAIRFSQVCVTYSSTYVLVAMSIDRYDAITHPMNF-SKSWKRARHLVAGAWL 247
            ...:| |:|:.||:...|.....:|::...:..:|::||.||.||..: :....|.|.|:..|||
Zfish    87 FPFLS-RSGDAACRIYNFLFELCSYATILNVATLSLERYLAICHPFRYRALRGGRTRRLLLAAWL 150

  Fly   248 ISALFSLPILVLY---------EEKLIQGHPQC------WIELGSPI--AWQVYMSLVSATLFAI 295
            .|||.:||:||..         .:..:|....|      |:...:.|  |:.:|:.:::...|..
Zfish   151 CSALVALPLLVATGTEGYVPAGRQTPVQNLTFCTSLSQHWVMYRTSIFTAFVLYLLVLAGVAFMC 215

  Fly   296 PALIISACYAIIVKTIWAKGSIFVPTERAGFGAAPA------RRASSRGIIPRAKVKTVKMTLTI 354
            .|:|:                    ..||..|.|.|      :..|:||  ..::.:|:...:.|
Zfish   216 RAMIL--------------------VLRAPMGPAEAGASGDHKHQSARG--KASRKQTILFLVLI 258

  Fly   355 VFVFIICWSPYIIFDLLQVFGQIPHSQ-TNIAIATFIQ------SLAPLNSAANPLIYCLFSSQV 412
            |....:||.|..|..|:.  ..:|.|. |...:.::|:      |...|:|..||::|.| ||:.
Zfish   259 VCALFVCWMPNQIRRLMT--AAVPKSSWTGSYLTSYIKLHPVADSFFYLSSVLNPMLYNL-SSRQ 320

  Fly   413 FRTLSRFPPFKWFTCCCKSYRNNSQQNRCHTVGRRLHNSCDSMRTLTTSLTVSRRSTNKTNARVV 477
            ||:     .|.....|..|.:        |...|.|.||..|..:..|...:.:||.|:  .|:.
Zfish   321 FRS-----AFLQTLLCRLSLQ--------HANRRTLENSGASKSSNNTLRPLLQRSLNR--IRMA 370

  Fly   478 ICERPTKVVTVPAMSE 493
            ...|.|.    |:.:|
Zfish   371 TSSRSTP----PSSAE 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCAP-R	NP_001368957.1	7tmA_NPSR	124..416	CDD:320325	88/327 (27%)
		TM helix 1	126..150	CDD:320325	10/24 (42%)
		TM helix 2	159..182	CDD:320325	7/25 (28%)
		TM helix 3	197..219	CDD:320325	2/21 (10%)
		TM helix 4	240..256	CDD:320325	8/15 (53%)
		TM helix 5	282..305	CDD:320325	4/22 (18%)
		TM helix 6	348..370	CDD:320325	6/21 (29%)
		TM helix 7	384..409	CDD:320325	8/30 (27%)
gpr39	NP_956711.1	7tm_1	37..314	CDD:278431	77/302 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000