DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCAP-R and PTGER2

DIOPT Version :9

Sequence 1:	NP_001368957.1	Gene:	CCAP-R / 2768688	FlyBaseID:	FBgn0039396	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_000947.2	Gene:	PTGER2 / 5732	HGNCID:	9594	Length:	358	Species:	Homo sapiens

Alignment Length:	384	Identity:	89/384 - (23%)
Similarity:	164/384 - (42%)	Gaps:	80/384 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 GNSTSSDPGEFDNLNSFYFYETEQF-------AVLWILFTVIVLGNSAVLFVMF--------INK 152
            ||:::....|        ..||.|:       |:..::|:..||||...|.::.        .:.
Human     2 GNASNDSQSE--------DCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRGDVGCSA 58

  Fly   153 NRKSRMNYF---IKQLALADLCVGLLNVLTDIIWRITISWRAGN----------LACKAIRFSQV 204
            .|:|.::.|   :.:|...|| :|     |.:|..:.::..|.|          .||....|:..
Human    59 GRRSSLSLFHVLVTELVFTDL-LG-----TCLISPVVLASYARNQTLVALAPESRACTYFAFAMT 117

  Fly   205 CVTYSSTYVLVAMSIDRYDAITHPMNFSKSWKRARHL--VAGAWLISALF-SLPILVLYEEKLIQ 266
            ..:.::..:|.||:::||.:|.||..:.:...|:..|  :...:.:|.|| |||:|..  .:.:|
Human   118 FFSLATMLMLFAMALERYLSIGHPYFYQRRVSRSGGLAVLPVIYAVSLLFCSLPLLDY--GQYVQ 180

  Fly   267 GHP--QCWIELGSPIAWQVYMSLVSATLFAIPALIISAC-YAIIVKTI----WAKGSIFVPTERA 324
            ..|  .|:|..|.....|:|     |||..:..:.:.|| :::|:..|    .::.|...|:..:
Human   181 YCPGTWCFIRHGRTAYLQLY-----ATLLLLLIVSVLACNFSVILNLIRMHRRSRRSRCGPSLGS 240

  Fly   325 GFGAAPARRASSRGIIPRAKVKTVKMTLTIVFV-FIICWSPYIIFDLLQVFGQIPHSQTNIAIAT 388
            |.|...|||...|  :..|:.....:.|.|:.: |.:|..|:.||..:        ::|:.....
Human   241 GRGGPGARRRGER--VSMAEETDHLILLAIMTITFAVCSLPFTIFAYM--------NETSSRKEK 295

  Fly   389 F-IQSL--APLNSAANPLIYCLFSSQVFRTLSRFPPFKWFTCCCKSYR-NNSQQNRCHT 443
            : :|:|  ..:||..:|.::.:....|.|.:      :...||..|.| .::.|..|.|
Human   296 WDLQALRFLSINSIIDPWVFAILRPPVLRLM------RSVLCCRISLRTQDATQTSCST 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCAP-R	NP_001368957.1	7tmA_NPSR	124..416	CDD:320325	78/333 (23%)
		TM helix 1	126..150	CDD:320325	8/38 (21%)
		TM helix 2	159..182	CDD:320325	6/25 (24%)
		TM helix 3	197..219	CDD:320325	4/21 (19%)
		TM helix 4	240..256	CDD:320325	6/18 (33%)
		TM helix 5	282..305	CDD:320325	7/23 (30%)
		TM helix 6	348..370	CDD:320325	7/22 (32%)
		TM helix 7	384..409	CDD:320325	5/27 (19%)
PTGER2	NP_000947.2	7tm_1	38..314	CDD:278431	70/298 (23%)
PTGER2	NP_000947.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	231..253		7/21 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000