DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCAP-R and avpr1ab

DIOPT Version :9

Sequence 1:	NP_001368957.1	Gene:	CCAP-R / 2768688	FlyBaseID:	FBgn0039396	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001284605.1	Gene:	avpr1ab / 555939	ZFINID:	ZDB-GENE-041210-105	Length:	410	Species:	Danio rerio

Alignment Length:	382	Identity:	124/382 - (32%)
Similarity:	178/382 - (46%)	Gaps:	45/382 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 TGGNSTSSDP-GEFDNLNSFYFYETEQFAVLWILFTVIVLGNSAVLFVMFINKNRKSRMNYFIKQ 164
            |..|:|  || |..:::...      :..||.:.|.|.|:||..||..|...|.:.|||:.|||.
Zfish     9 TANNTT--DPFGRNEDVAKM------EITVLSVTFLVAVVGNLCVLLAMHNTKKKSSRMHLFIKH 65

  Fly   165 LALADLCVGLLNVLTDIIWRITISWRAGNLACKAIRFSQVCVTYSSTYVLVAMSIDRYDAITHPM 229
            |:||||.|....||..:.|.||..:...:..|:.::..||...::|||::|.|::|||.||.||:
Zfish    66 LSLADLVVAFFQVLPQLCWEITYRFYGPDFLCRIVKHLQVLGMFASTYMMVMMTLDRYIAICHPL 130

  Fly   230 -NFSKSWKRARHLVAGAWLISALFSLPILVLYEEKLIQGHP---QCWIELGSPIAWQVYMSLVSA 290
             ...:..:||..::...||.|.|.|.|...::....||...   .||.....|...:.|::.::.
Zfish   131 KTLQQPTRRAYIMICSTWLCSLLLSTPQYFIFSLSEIQNGSDVYDCWGHFIEPWGIRAYITWITV 195

  Fly   291 TLFAIPALIISACYAIIVKTIW-------AKGSIFVPTERAGFGAAPARRASSRGIIPRAKVKTV 348
            .:|.||.:|:..||..|..:||       .:|:...|..    |.......||..||.|||::||
Zfish   196 GIFLIPVVILMICYGFICHSIWKNFKCKTKRGAAHNPKS----GMIGKASVSSVTIISRAKLRTV 256

  Fly   349 KMTLTIVFVFIICWSPYIIFDLLQVFGQ-IPHSQTNIAIATFIQSLAPLNSAANPLIYCLFSSQV 412
            |||..||..:|:||:|:....:..|:.: .....:..|..|....||.|||..||.||.|||..:
Zfish   257 KMTFVIVLAYIVCWAPFFTVQMWSVWDENFSWDDSENAAVTLSALLASLNSCCNPWIYMLFSGHL 321

  Fly   413 FRT-LSRFPPFKWFTCCCKSYRNNSQQNRCHTVGRRLHNSCDSMR--TLTTSLTVSR 466
            ... |..||  .|          |..||..|.     .:|..|:|  ||.:.||..|
Zfish   322 LHDFLGCFP--CW----------NKPQNTLHK-----EDSDSSIRRNTLLSKLTSVR 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCAP-R	NP_001368957.1	7tmA_NPSR	124..416	CDD:320325	102/304 (34%)
		TM helix 1	126..150	CDD:320325	10/23 (43%)
		TM helix 2	159..182	CDD:320325	11/22 (50%)
		TM helix 3	197..219	CDD:320325	7/21 (33%)
		TM helix 4	240..256	CDD:320325	5/15 (33%)
		TM helix 5	282..305	CDD:320325	6/22 (27%)
		TM helix 6	348..370	CDD:320325	10/21 (48%)
		TM helix 7	384..409	CDD:320325	12/24 (50%)
avpr1ab	NP_001284605.1	7tm_4	35..>162	CDD:304433	49/126 (39%)
		7tm_1	41..314	CDD:278431	92/276 (33%)
		7tm_4	<116..331	CDD:304433	71/220 (32%)
		DUF1856	339..386	CDD:286120	9/28 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	163	1.000	Domainoid score	I3913
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	179	1.000	Inparanoid score	I4004
OMA	1	1.010	-	-		QHG45270
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24293
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.060