DRSC/TRiP Functional Genomics Resources

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Protein Alignment CCAP-R and AVPR2

DIOPT Version :9

Sequence 1:NP_001368957.1 Gene:CCAP-R / 2768688 FlyBaseID:FBgn0039396 Length:521 Species:Drosophila melanogaster
Sequence 2:NP_000045.1 Gene:AVPR2 / 554 HGNCID:897 Length:371 Species:Homo sapiens


Alignment Length:381 Identity:117/381 - (30%)
Similarity:175/381 - (45%) Gaps:33/381 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    91 TTAAPSHDLETGGNSTSSDPGEFDNLNSFYFYETEQFAVLWILFTVIVLGNSAVLFVMFINKNRK 155
            |:|.|.|.......|.||.....|..:.  .....:.|:|.|:|..:.|.|..||..: ..:.|:
Human     7 TSAVPGHPSLPSLPSNSSQERPLDTRDP--LLARAELALLSIVFVAVALSNGLVLAAL-ARRGRR 68

  Fly   156 SR---MNYFIKQLALADLCVGLLNVLTDIIWRITISWRAGNLACKAIRFSQVCVTYSSTYVLVAM 217
            ..   ::.||..|.||||.|.|..||..:.|:.|..:|..:..|:|:::.|:...|:|:|:::||
Human    69 GHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQMVGMYASSYMILAM 133

  Fly   218 SIDRYDAITHPM-----NFSKSWKRARHLVAGAWLISALFSLPILVLYEEKLIQGH---PQCWIE 274
            ::||:.||..||     .....|.|.   |..||..|.|.|||.|.::.::.::|.   ..||..
Human   134 TLDRHRAICRPMLAYRHGSGAHWNRP---VLVAWAFSLLLSLPQLFIFAQRNVEGGSGVTDCWAC 195

  Fly   275 LGSPIAWQVYMSLVSATLFAIPALIISACYAIIVKTIWAKGSIFVPTERAGFGAAPARRASSRG- 338
            ...|...:.|::.::..:|..|.|.|:||..:|.:.|.| ..:..|:||.| |....||..|.| 
Human   196 FAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHA-SLVPGPSERPG-GRRRGRRTGSPGE 258

  Fly   339 --IIPRAKVKTVKMTLTIVFVFIICWSPYIIFDLLQVFGQIPHSQTNIAIATFIQSLAPLNSAAN 401
              .:..|..|||:|||.||.|:::||:|:.:..|...:.  |.:....|....:..||.|||..|
Human   259 GAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWD--PEAPLEGAPFVLLMLLASLNSCTN 321

  Fly   402 PLIYCLFSSQVFRTLSRFPPFKWFTCCCKSYRNNS---QQNRCHTVGRRLHNSCDS 454
            |.||..|||.|...|      :...||.:.....|   |...|.|....|.....|
Human   322 PWIYASFSSSVSSEL------RSLLCCARGRTPPSLGPQDESCTTASSSLAKDTSS 371

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CCAP-RNP_001368957.1 7tmA_NPSR 124..416 CDD:320325 100/305 (33%)
TM helix 1 126..150 CDD:320325 8/23 (35%)
TM helix 2 159..182 CDD:320325 11/22 (50%)
TM helix 3 197..219 CDD:320325 7/21 (33%)
TM helix 4 240..256 CDD:320325 7/15 (47%)
TM helix 5 282..305 CDD:320325 7/22 (32%)
TM helix 6 348..370 CDD:320325 10/21 (48%)
TM helix 7 384..409 CDD:320325 10/24 (42%)
AVPR2NP_000045.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..30 7/22 (32%)
7tmA_V2R 45..326 CDD:320510 93/288 (32%)
TM helix 2 74..101 CDD:320510 12/26 (46%)
TM helix 3 112..142 CDD:320510 11/29 (38%)
TM helix 4 155..176 CDD:320510 10/23 (43%)
TM helix 5 202..231 CDD:320510 8/28 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 240..259 9/19 (47%)
TM helix 6 264..294 CDD:320510 14/29 (48%)
TM helix 7 304..326 CDD:320510 9/21 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 349..371 5/21 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S6043
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3458
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.980

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