DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCAP-R and AVPR1B

DIOPT Version :9

Sequence 1:	NP_001368957.1	Gene:	CCAP-R / 2768688	FlyBaseID:	FBgn0039396	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_000698.1	Gene:	AVPR1B / 553	HGNCID:	896	Length:	424	Species:	Homo sapiens

Alignment Length:	418	Identity:	133/418 - (31%)
Similarity:	210/418 - (50%)	Gaps:	47/418 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 AAPSHDLETGGNSTSSDPGEFDNLNSFYFYETEQFA--VLWILFTVIVL---GNSAVLFVMFINK 152
            :.|..|.......|.|.|    |..:.:....|:.|  .:.:|.||:||   ||.|||..:....
Human     3 SGPLWDANPTPRGTLSAP----NATTPWLGRDEELAKVEIGVLATVLVLATGGNLAVLLTLGQLG 63

  Fly   153 NRKSRMNYFIKQLALADLCVGLLNVLTDIIWRITISWRAGNLACKAIRFSQVCVTYSSTYVLVAM 217
            .::|||:.|:..|||.||.|.|..||..::|.||..::..:|.|:|:::.||...::|||:|:||
Human    64 RKRSRMHLFVLHLALTDLAVALFQVLPQLLWDITYRFQGPDLLCRAVKYLQVLSMFASTYMLLAM 128

  Fly   218 SIDRYDAITHPM-NFSKSWKRARHLVAGAWLISALFSLPILVLYE-EKLIQGHP--QCWIELGSP 278
            ::|||.|:.||: :..:..:....|:|..||::|:||||.:.::. .::|||..  .||.:.|.|
Human   129 TLDRYLAVCHPLRSLQQPGQSTYLLIAAPWLLAAIFSLPQVFIFSLREVIQGSGVLDCWADFGFP 193

  Fly   279 IAWQVYMSLVSATLFAIPALIISACYAIIVKTIWAKGSIFVPTERAGFG-------------AAP 330
            ...:.|::..:..:|.:|..:::|||::|...|.....:.....|.|.|             ||.
Human   194 WGPRAYLTWTTLAIFVLPVTMLTACYSLICHEICKNLKVKTQAWRVGGGGWRTWDRPSPSTLAAT 258

  Fly   331 AR----RASSRGIIPRAKVKTVKMTLTIVFVFIICWSPYIIFDLLQVFGQ-IP-HSQTNIAIATF 389
            .|    |.||...|.|||::|||||..||..:|.||:|:....:..|:.: .| ...||:|. |.
Human   259 TRGLPSRVSSINTISRAKIRTVKMTFVIVLAYIACWAPFFSVQMWSVWDKNAPDEDSTNVAF-TI 322

  Fly   390 IQSLAPLNSAANPLIYCLFSSQVFRTLSRFPPFKWFTCC-------CKSYRNNSQQNRCHTVGRR 447
            ...|..|||..||.||..|:|.:   |.|  |.:...||       .:...:.|..:|..|:..|
Human   323 SMLLGNLNSCCNPWIYMGFNSHL---LPR--PLRHLACCGGPQPRMRRRLSDGSLSSRHTTLLTR 382

  Fly   448 LHNSCDSMRTLTTSLTVSRRSTNKTNAR 475
              :||.:..:|:.|||:|.|...:.:.|
Human   383 --SSCPATLSLSLSLTLSGRPRPEESPR 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCAP-R	NP_001368957.1	7tmA_NPSR	124..416	CDD:320325	109/319 (34%)
		TM helix 1	126..150	CDD:320325	11/28 (39%)
		TM helix 2	159..182	CDD:320325	10/22 (45%)
		TM helix 3	197..219	CDD:320325	9/21 (43%)
		TM helix 4	240..256	CDD:320325	8/15 (53%)
		TM helix 5	282..305	CDD:320325	5/22 (23%)
		TM helix 6	348..370	CDD:320325	10/21 (48%)
		TM helix 7	384..409	CDD:320325	10/24 (42%)
AVPR1B	NP_000698.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22		5/22 (23%)
		7tm_1	51..338	CDD:278431	98/287 (34%)
		7tm_4	52..>222	CDD:304433	59/169 (35%)
		DUF1856	362..412	CDD:286120	13/49 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..417		3/11 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45270
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3458
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.040