DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCAP-R and OXTR

DIOPT Version :9

Sequence 1:	NP_001368957.1	Gene:	CCAP-R / 2768688	FlyBaseID:	FBgn0039396	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_000907.2	Gene:	OXTR / 5021	HGNCID:	8529	Length:	389	Species:	Homo sapiens

Alignment Length:	396	Identity:	114/396 - (28%)
Similarity:	196/396 - (49%)	Gaps:	48/396 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 GNSTSSDPGEFDNLNSFYFYETEQFAVLWILFTVIVLGNSAVLFVMFINKNRKSRMNYFIKQLAL 167
            ||.|:..|...:.|      ...:.|||.::..:.:.||:.||..:...:.:.||:.:|:|.|::
Human    25 GNRTAGPPRRNEAL------ARVEVAVLCLILLLALSGNACVLLALRTTRQKHSRLFFFMKHLSI 83

  Fly   168 ADLCVGLLNVLTDIIWRITISWRAGNLACKAIRFSQVCVTYSSTYVLVAMSIDRYDAITHPMNFS 232
            |||.|.:..||..::|.||..:...:|.|:.:::.||...::|||:|:.||:||..||..|:
Human    84 ADLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQVVGMFASTYLLLLMSLDRCLAICQPL--- 145

  Fly   233 KSWKRA--RHLVAGAWLISALFSLPILVLYE-EKLIQGHPQCWIELGSPIAWQVYMSLVSATLFA 294
            :|.:|.  |..|...||...:.|.|.:.::. .::..|...||.....|...:.|::.::..::.
Human   146 RSLRRRTDRLAVLATWLGCLVASAPQVHIFSLREVADGVFDCWAVFIQPWGPKAYITWITLAVYI 210

  Fly   295 IPALIISACYAIIVKTIWAKGSIFVPTERAGFGAAP------------ARRASSRGIIPRAKVKT 347
            :|.::::|||.:|...||.  ::.:.|..|....||            ..|.||..:|.:||::|
Human   211 VPVIVLAACYGLISFKIWQ--NLRLKTAAAAAAEAPEGAAAGDGGRVALARVSSVKLISKAKIRT 273

  Fly   348 VKMTLTIVFVFIICWSPYIIFDLLQVFGQIPHSQTNIAIATFIQSLAPLNSAANPLIYCLFSSQV 412
            ||||..||..||:||:|:....:..|:......:.:..|  .:..||.|||..||.||.||:..:
Human   274 VKMTFIIVLAFIVCWTPFFFVQMWSVWDANAPKEASAFI--IVMLLASLNSCCNPWIYMLFTGHL 336

  Fly   413 FRTLSRFPPFKWFTCCCKSYRNNSQQNRCHTVGRRLHNSCDSMRTLTTSLTVSRRSTNKTNARVV 477
            |..|     .:.|.||..||..          ||||..:..|.::.::|..:|.||:::.:
Human   337 FHEL-----VQRFLCCSASYLK----------GRRLGETSASKKSNSSSFVLSHRSSSQRS---- 382

  Fly   478 ICERPT 483
             |.:|:
Human   383 -CSQPS 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCAP-R	NP_001368957.1	7tmA_NPSR	124..416	CDD:320325	92/306 (30%)
		TM helix 1	126..150	CDD:320325	7/23 (30%)
		TM helix 2	159..182	CDD:320325	9/22 (41%)
		TM helix 3	197..219	CDD:320325	7/21 (33%)
		TM helix 4	240..256	CDD:320325	4/15 (27%)
		TM helix 5	282..305	CDD:320325	4/22 (18%)
		TM helix 6	348..370	CDD:320325	11/21 (52%)
		TM helix 7	384..409	CDD:320325	11/24 (46%)
OXTR	NP_000907.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	7..31		3/5 (60%)
		7tmA_OT_R	40..340	CDD:320509	92/306 (30%)
		TM helix 1	41..67	CDD:320509	7/25 (28%)
		TM helix 2	74..101	CDD:320509	10/26 (38%)
		TM helix 3	112..142	CDD:320509	12/29 (41%)
		TM helix 4	152..173	CDD:320509	6/20 (30%)
		TM helix 5	197..226	CDD:320509	6/28 (21%)
		TM helix 6	268..298	CDD:320509	14/29 (48%)
		TM helix 7	308..333	CDD:320509	11/26 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	361..389		7/32 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45270
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010