DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCAP-R and NPSR1

DIOPT Version :9

Sequence 1:	NP_001368957.1	Gene:	CCAP-R / 2768688	FlyBaseID:	FBgn0039396	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001287864.1	Gene:	NPSR1 / 387129	HGNCID:	23631	Length:	390	Species:	Homo sapiens

Alignment Length:	381	Identity:	139/381 - (36%)
Similarity:	207/381 - (54%)	Gaps:	50/381 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 NGTQGAGGVAAGGESLTPTDVAAVNLTYFTPAISHVMLAPTTIATTTASATMVQIQTTAAPSHDL 99
            |.|:|:...:..|::|..:.||......||..:.
Human     4 NFTEGSFDSSGTGQTLDSSPVACTETVTFTEVVE------------------------------- 37

  Fly   100 ETGGNSTSSDPGEFDNLNSFYFYETEQFAVLWILFTVIVLGNSAVLFVMFINKNRKSRMNYFIKQ 164
                   ..:.|.|     :|.::|||...||:||...::|||.|||..: .:.:||||.:|:.|
Human    38 -------GKEWGSF-----YYSFKTEQLITLWVLFVFTIVGNSVVLFSTW-RRKKKSRMTFFVTQ 89

  Fly   165 LALADLCVGLLNVLTDIIWRITISWRAGNLACKAIRFSQVCVTYSSTYVLVAMSIDRYDAITHPM 229
            ||:.|...||:|:||||.||.|..:.|.:|.|:.:|:.||.:.|:||||||::|||||.||.:||
Human    90 LAITDSFTGLVNILTDINWRFTGDFTAPDLVCRVVRYLQVVLLYASTYVLVSLSIDRYHAIVYPM 154

  Fly   230 NFSKSWKRARHLVAGAWLISALFSLPILVLYEEK-LIQGHPQCWIELGSPIAWQVYMSLVSATLF 293
            .|.:..|:||.|:..||.:|.|||:|.|:::.:: |..|..|||........|..||::|:..::
Human   155 KFLQGEKQARVLIVIAWSLSFLFSIPTLIIFGKRTLSNGEVQCWALWPDDSYWTPYMTIVAFLVY 219

  Fly   294 AIPALIISACYAIIVKTIWAKGSIFVPTERAGFGAAPARRASS--RGIIPRAKVKTVKMTLTIVF 356
            .||..|||..|.|:::|||.|...:   |......:..:..||  ||:|.:||:|.:|.::.|:.
Human   220 FIPLTIISIMYGIVIRTIWIKSKTY---ETVISNCSDGKLCSSYNRGLISKAKIKAIKYSIIIIL 281

  Fly   357 VFIICWSPYIIFDLLQVFGQIPHSQTNIAIATFIQSLAPLNSAANPLIYCLFSSQV 412
            .||.|||||.:||:|..|..:|.:|.....:..||:|..||||.||||||:|||.:
Human   282 AFICCWSPYFLFDILDNFNLLPDTQERFYASVIIQNLPALNSAINPLIYCVFSSSI 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCAP-R	NP_001368957.1	7tmA_NPSR	124..416	CDD:320325	127/292 (43%)
		TM helix 1	126..150	CDD:320325	11/23 (48%)
		TM helix 2	159..182	CDD:320325	11/22 (50%)
		TM helix 3	197..219	CDD:320325	10/21 (48%)
		TM helix 4	240..256	CDD:320325	7/15 (47%)
		TM helix 5	282..305	CDD:320325	8/22 (36%)
		TM helix 6	348..370	CDD:320325	10/21 (48%)
		TM helix 7	384..409	CDD:320325	13/24 (54%)
NPSR1	NP_001287864.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22		5/17 (29%)
NPSR1	NP_001287864.1	7tm_1	66..330	CDD:278431	114/267 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	225	1.000	Domainoid score	I2554
eggNOG	1	0.900	-	-		E33208_3BIK5
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H45515
Inparanoid	1	1.050	257	1.000	Inparanoid score	I3161
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1034048at2759
OrthoFinder	1	1.000	-	-		FOG0007559
OrthoInspector	1	1.000	-	-		oto90697
orthoMCL	1	0.900	-	-		OOG6_111092
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3458
SonicParanoid	1	1.000	-	-		X5676
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.850