DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCAP-R and srv-26

DIOPT Version :9

Sequence 1:	NP_001368957.1	Gene:	CCAP-R / 2768688	FlyBaseID:	FBgn0039396	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_872113.1	Gene:	srv-26 / 353424	WormBaseID:	WBGene00005737	Length:	335	Species:	Caenorhabditis elegans

Alignment Length:	413	Identity:	83/413 - (20%)
Similarity:	153/413 - (37%)	Gaps:	118/413 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 NSTSSDPGEFDNLNSFYFYETEQFAVLWILFTVIVLGNSAVLFVMFINKNRKSRMNYFIKQLALA 168
            ||| .:|..: ..|.||........:.:|:...:|.       :..::|:.::.....:.|..:|
Worm     2 NST-LEPSTW-GFNVFYGMSIVTLPLYFIILVCLVR-------LRQVSKSYRTTFYSLLLQHCIA 57

  Fly   169 DLCVGLLNVLT-------DIIWRITISWRAGNLACKAIRFSQVCVTYSSTYV----LVAMSIDRY 222
            |: :.:|..:.       .:|.:....::...:|.....     :.|.|.|:    ::.:|:.||
Worm    58 DI-ISMLGYIALTPAREISVIRQFYFDYQEYYIAAATYN-----IIYVSLYIRCIGILLLSLQRY 116

  Fly   223 DAITHP-------MNFSKSWKRARHLVAGAWLISALFSLPIL--------------VLYEEKLIQ 266
            ..||.|       :..|.|||    :|...|::..|.|:.:|              |:.|:.:.|
Worm   117 FVITSPHSNLTIKIQTSASWK----VVLVYWILPLLLSVIVLKDSDMYFNDVVDMNVIIEKSITQ 177

  Fly   267 GHPQCWIELGSPIAWQVYMSLVSATLFAIPALIISACYAIIVKTIWAKGSIFVPTERAGFGAAPA 331
            .:                      |..|:  |::|  :..|:.: :|.|::|       |.....
Worm   178 RN----------------------TTMAL--LVVS--FVCIISS-FAYGALF-------FFIRKN 208

  Fly   332 RRASSRGIIPRAKVKTVKMTLTIVFVFIICWSPYIIFDLLQVFGQIPHSQTNIAIATFIQSLAPL 396
            .|..||.:  |.:|:.......::|.|   ::..|.:.:|....:...:.....:.|....|:..
Worm   209 TRILSRSL--RREVRLAFQVFVLLFAF---FAILIFYAILNYCSRAQMTAEMFYLRTIYPMLSGF 268

  Fly   397 NSAANPLIYCL------FSSQVFRTLSRFPPFKWFTCCCKSYRNNSQQNRCHTVGRRLHNSCDSM 455
            .|..||  ||:      .:.||.:::|           ||.|.|:..|     |...|.||  :.
Worm   269 LSYMNP--YCILLLNHDLARQVVKSVS-----------CKEYENSEVQ-----VSGILSNS--TK 313

  Fly   456 RTLTTSLTVSRRSTNKTNARVVI 478
            :.|.|:...||.|..  |.|.||
Worm   314 QQLPTTARPSRISNE--NRRTVI 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCAP-R	NP_001368957.1	7tmA_NPSR	124..416	CDD:320325	57/329 (17%)
		TM helix 1	126..150	CDD:320325	2/23 (9%)
		TM helix 2	159..182	CDD:320325	4/29 (14%)
		TM helix 3	197..219	CDD:320325	3/25 (12%)
		TM helix 4	240..256	CDD:320325	4/15 (27%)
		TM helix 5	282..305	CDD:320325	4/22 (18%)
		TM helix 6	348..370	CDD:320325	3/21 (14%)
		TM helix 7	384..409	CDD:320325	7/30 (23%)
srv-26	NP_872113.1	7TM_GPCR_Srv	15..294	CDD:370977	60/347 (17%)
		TM helix 2	47..73	CDD:341315	4/26 (15%)
		TM helix 3	86..120	CDD:341315	7/38 (18%)
		TM helix 4	134..153	CDD:341315	7/22 (32%)
		TM helix 5	177..200	CDD:341315	7/49 (14%)
		TM helix 6	217..243	CDD:341315	5/28 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24224
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100