DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCAP-R and GPR150

DIOPT Version :9

Sequence 1:	NP_001368957.1	Gene:	CCAP-R / 2768688	FlyBaseID:	FBgn0039396	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_954713.1	Gene:	GPR150 / 285601	HGNCID:	23628	Length:	434	Species:	Homo sapiens

Alignment Length:	345	Identity:	87/345 - (25%)
Similarity:	154/345 - (44%)	Gaps:	63/345 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 LWILFTVIVLGNSAVLFVM------FINKNRKSRMNYFIKQLALADL--CVGLLNVLTDIIWRIT 186
            |.::..|.|.||:.||..:      :....|: :|::.:.|||||||  |.|  ..|:.:.|.:.
Human    49 LGVILVVAVAGNTTVLCRLCGGGGPWAGPKRR-KMDFLLVQLALADLYACGG--TALSQLAWELL 110

  Fly   187 ISWRA--GNLACKAIRFSQVCVTYSSTYVLVAMSIDRYDAITHPMNFSKSWKRARHLVAGAWLIS 249
            ...||  |:|||:.::..|.....:|.:::|.::::|..|:..|......   ||.|.|..||::
Human   111 GEPRAATGDLACRFLQLLQASGRGASAHLVVLIALERRRAVRLPHGRPLP---ARALAALGWLLA 172

  Fly   250 ALFSLPILVLYEEKLIQGH---------PQCWIELGSPIA-------------------W--QVY 284
            .|.:||     ...:::|.         |...::.|:|.|                   |  |||
Human   173 LLLALP-----PAFVVRGDSPSPLPPPPPPTSLQPGAPPAARAWPGERRCHGIFAPLPRWHLQVY 232

  Fly   285 MSLVSATLFAIPALIIS-ACYAIIVKTIWAKGSIFVPTERAGFGAAPARRASSRGIIPRAKVKTV 348
            ....:...|..|..::. ||..::  ::|.:.....|...|.:.|:|. ||.:...:|||||:::
Human   233 AFYEAVAGFVAPVTVLGVACGHLL--SVWWRHRPQAPAAAAPWSASPG-RAPAPSALPRAKVQSL 294

  Fly   349 KMTLTIVFVFIICWSPYIIFDLLQVFGQIPHSQ-TNIAIATFIQSLAPLNSAANPLIYCLFSS-- 410
            ||:|.:..:|:.|..||....|...:...|... ....::..::.:|..|||.||.:|..|.:
Human   295 KMSLLLALLFVGCELPYFAARLAAAWSSGPAGDWEGEGLSAALRVVAMANSALNPFVYLFFQAGD 359

  Fly   411 -QVFRTLSRFPPFKWFTCCC 429
             ::.|.|.:    :..:.||
Human   360 CRLRRQLRK----RLGSLCC 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCAP-R	NP_001368957.1	7tmA_NPSR	124..416	CDD:320325	84/330 (25%)
		TM helix 1	126..150	CDD:320325	7/25 (28%)
		TM helix 2	159..182	CDD:320325	10/24 (42%)
		TM helix 3	197..219	CDD:320325	3/21 (14%)
		TM helix 4	240..256	CDD:320325	6/15 (40%)
		TM helix 5	282..305	CDD:320325	7/23 (30%)
		TM helix 6	348..370	CDD:320325	7/21 (33%)
		TM helix 7	384..409	CDD:320325	7/24 (29%)
GPR150	NP_954713.1	7tm_1	59..352	CDD:278431	78/306 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	188..210		4/21 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..434
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000