DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCAP-R and Avpr2

DIOPT Version :9

Sequence 1:	NP_001368957.1	Gene:	CCAP-R / 2768688	FlyBaseID:	FBgn0039396	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	XP_038955420.1	Gene:	Avpr2 / 25108	RGDID:	2186	Length:	403	Species:	Rattus norvegicus

Alignment Length:	398	Identity:	120/398 - (30%)
Similarity:	183/398 - (45%)	Gaps:	44/398 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 ISHVMLAPTTIATTTASATMVQIQTTAAPSHDLETGGNSTSSDPGEFDNLNSFYFYETEQFAVLW 131
            |:|    |..:..:|.||........::||:         ||.....|:.:....  ..:.|:|.
  Rat    28 INH----PIMLLVSTVSAVPGLFSPPSSPSN---------SSQEELLDDRDPLLV--RAELALLS 77

  Fly   132 ILFTVIVLGNSAVLFVMFINKNRKSR---MNYFIKQLALADLCVGLLNVLTDIIWRITISWRAGN 193
            .:|..:.|.|..||..: |.:.|:.|   |:.||..|.||||.|.|..||..:.|..|..:...:
  Rat    78 TIFVAVALSNGLVLGAL-IRRGRRGRWAPMHVFISHLCLADLAVALFQVLPQLAWDATDRFHGPD 141

  Fly   194 LACKAIRFSQVCVTYSSTYVLVAMSIDRYDAITHPM-----NFSKSWKRARHLVAGAWLISALFS 253
            ..|:|:::.|:...|:|:|:::||::||:.||..||     .....|.|.   |..||..|.|.|
  Rat   142 ALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGGGARWNRP---VLVAWAFSLLLS 203

  Fly   254 LPILVLYEEKLI---QGHPQCWIELGSPIAWQVYMSLVSATLFAIPALIISACYAIIVKTIWAKG 315
            ||.|.::.::.:   .|...||.....|...:.|::.::..:|..|||.|:||..:|.:.|.| .
  Rat   204 LPQLFIFAQRDVGNGSGVFDCWARFAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHA-S 267

  Fly   316 SIFVPTERAGFGAAPARRAS-SRGI-IPRAKVKTVKMTLTIVFVFIICWSPYIIFDLLQVFGQIP 378
            .:..|:||||......|..| |.|. :..|..|||:|||.||.|:::||:|:.:..|...:.  |
  Rat   268 LVPGPSERAGRRRRGRRTGSPSEGAHVSAAMAKTVRMTLVIVIVYVLCWAPFFLVQLWAAWD--P 330

  Fly   379 HSQTNIAIATFIQSLAPLNSAANPLIYCLFSSQVFRTLSRFPPFKWFTCCCKSYRNNS---QQNR 440
            .:.........:..||.|||..||.||..|||.|...|      :...||.:.:..:|   |...
  Rat   331 EAPLERPPFVLLMLLASLNSCTNPWIYASFSSSVSSEL------RSLLCCAQRHTTHSLGPQDES 389

  Fly   441 CHTVGRRL 448
            |.|....|
  Rat   390 CATASSSL 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCAP-R	NP_001368957.1	7tmA_NPSR	124..416	CDD:320325	101/304 (33%)
		TM helix 1	126..150	CDD:320325	7/23 (30%)
		TM helix 2	159..182	CDD:320325	11/22 (50%)
		TM helix 3	197..219	CDD:320325	7/21 (33%)
		TM helix 4	240..256	CDD:320325	7/15 (47%)
		TM helix 5	282..305	CDD:320325	8/22 (36%)
		TM helix 6	348..370	CDD:320325	10/21 (48%)
		TM helix 7	384..409	CDD:320325	9/24 (38%)
Avpr2	XP_038955420.1	7tmA_V2R	70..358	CDD:320510	96/294 (33%)
		TM helix 1	72..96	CDD:320510	7/24 (29%)
		TM helix 2	107..130	CDD:320510	11/22 (50%)
		TM helix 3	145..167	CDD:320510	7/21 (33%)
		TM helix 4	190..206	CDD:320510	8/18 (44%)
		TM helix 5	235..258	CDD:320510	8/22 (36%)
		TM helix 6	302..324	CDD:320510	10/21 (48%)
		TM helix 7	336..358	CDD:320510	8/21 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000