DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCAP-R and ntr-2

DIOPT Version :9

Sequence 1:	NP_001368957.1	Gene:	CCAP-R / 2768688	FlyBaseID:	FBgn0039396	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_510477.1	Gene:	ntr-2 / 184471	WormBaseID:	WBGene00008808	Length:	398	Species:	Caenorhabditis elegans

Alignment Length:	405	Identity:	106/405 - (26%)
Similarity:	183/405 - (45%)	Gaps:	70/405 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 LNSFYFYETEQFAVLWILFTVIVLGNSAVLFVMF----INKNRKSRMNYFIKQLALADLCVGLLN 176
            ::..||....|.||:    .|.:|||..:|||:|    :.|.|.|.:...|....:|||...||:
Worm    17 MSQIYFLVVYQTAVM----IVSLLGNLFLLFVIFRANQVMKRRVSPVQLLIIHTCVADLLFALLS 77

  Fly   177 VLTDII-WRITISWRAGNLACKAIRFSQVCVTYSSTYVLVAMSIDRYDAITHPMNFSKS--WKRA 238
            :.|:|: .|....:...|..||.:|:.|:...|:|.::|||:|.|||.||..|:...:|  ::|.
Worm    78 LGTEILTLRTYPQYYGSNFVCKLMRYVQMFPMYASPFLLVAISADRYQAICRPLAHFRSSRYRRP 142

  Fly   239 RHLVAGAWLISALFSLPILVLYEE-------KLIQGHPQCWIELGSPIAWQVYMSLVSATLFAIP 296
            ..:.|.||.::.:.|:|...::.:       ..|.|..:..:::       .|:.:.:...:.:|
Worm   143 NWMAAIAWGLALVLSIPQFFVWTKHSKTGRCSTIYGQNKNTVKI-------TYVIMFNTLAWLLP 200

  Fly   297 ALIISACYAIIVKTIWAKGSIFV----PTERAGFGAAPAR-------RASSRGI------IPRAK 344
            :::.:..|..:.|.:....:..|    ..:|.|..::.|.       |..|:|.      ..|.:
Worm   201 SILAAVFYYCVCKAVRLSSTKSVRAMDSQKRNGKYSSGATEDYIEELRKKSKGFRQQMSEFDRKR 265

  Fly   345 VKTVKMTLTIVFVFIICWSPYIIFDLLQ-VFGQIPHSQTNIAIATFIQSLAPLNSAANPLIYCLF 408
            |:||::|:|||......|.|:.:.:::| ::.:|.|    |....::..|..|||..||.||.||
Worm   266 VQTVRLTITIVACNFFLWMPFCLINVIQALWPEISH----IMFINYVAILGNLNSCLNPWIYILF 326

  Fly   409 -----------SSQVFRTLSRFPPFKWFTCCCKSYRNNSQQNRCH---TVGRRLHNSCDSMRTLT 459
                       |.:.|..:::...|:.|.|...:..||: .|.||   ....|.....||..|.:
Worm   327 NRSHVRKALCRSRRSFTEVTKKRSFENFECSSTATMNNN-YNNCHAYTAFSNRSQLKFDSYATDS 390

  Fly   460 TSLTVSRRSTNKTNA 474
            |||        |||:
Worm   391 TSL--------KTNS 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCAP-R	NP_001368957.1	7tmA_NPSR	124..416	CDD:320325	86/334 (26%)
		TM helix 1	126..150	CDD:320325	11/27 (41%)
		TM helix 2	159..182	CDD:320325	7/22 (32%)
		TM helix 3	197..219	CDD:320325	8/21 (38%)
		TM helix 4	240..256	CDD:320325	4/15 (27%)
		TM helix 5	282..305	CDD:320325	2/22 (9%)
		TM helix 6	348..370	CDD:320325	7/21 (33%)
		TM helix 7	384..409	CDD:320325	11/35 (31%)
ntr-2	NP_510477.1	7tm_1	37..323	CDD:278431	75/296 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6043
OMA	1	1.010	-	-		QHG45270
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24224
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.060