DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CCAP-R and Oxtr

DIOPT Version :9

Sequence 1:	NP_001368957.1	Gene:	CCAP-R / 2768688	FlyBaseID:	FBgn0039396	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001074616.1	Gene:	Oxtr / 18430	MGIID:	109147	Length:	388	Species:	Mus musculus

Alignment Length:	409	Identity:	118/409 - (28%)
Similarity:	200/409 - (48%)	Gaps:	59/409 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 DLETG------GNSTSSDPGEFDNLNSFYFYETEQFAVLWILFTVIVLGNSAVLFVMFINKNRKS 156
            ||.:|      ||.|:..|...:.|      ...:.|||.::..:.:.||:.||..:...:::.|
Mouse    14 DLGSGVPPGAEGNLTAGPPRRNEAL------ARVEVAVLCLILFLALSGNACVLLALRTTRHKHS 72

  Fly   157 RMNYFIKQLALADLCVGLLNVLTDIIWRITISWRAGNLACKAIRFSQVCVTYSSTYVLVAMSIDR 221
            |:.:|:|.|::|||.|.:..||..::|.||..:...:|.|:.:::.||...::|||:|:.||:||
Mouse    73 RLFFFMKHLSIADLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQVVGMFASTYLLLLMSLDR 137

  Fly   222 YDAITHPMNFSKSWKRA--RHLVAGAWLISALFSLPILVLYE-EKLIQGHPQCWIELGSPIAWQV 283
            ..||..|:   :|.:|.  |..|...||...:.|:|.:.::. .::..|...||.....|...:.
Mouse   138 CLAICQPL---RSLRRRTDRLAVLATWLGCLVASVPQVHIFSLREVADGVFDCWAVFIQPWGPKA 199

  Fly   284 YMSLVSATLFAIPALIISACYAIIVKTIW-------------AKGSIFVPTERAGFGAAPARRAS 335
            |::.::..::.:|.::::|||.:|...||             |:||    ....|.|.|...|.|
Mouse   200 YVTWITLAVYIVPVIVLAACYGLISFKIWQNLRLKTAAAAAAAEGS----DAAGGAGRAALARVS 260

  Fly   336 SRGIIPRAKVKTVKMTLTIVFVFIICWSPYIIFDLLQVFG-QIPHSQTNIAIATFIQSLAPLNSA 399
            |..:|.:||::|||||..||..||:||:|:....:..|:. ..|...:...||..   ||.|||.
Mouse   261 SVKLISKAKIRTVKMTFIIVLAFIVCWTPFFFVQMWSVWDVNAPKEASAFIIAML---LASLNSC 322

  Fly   400 ANPLIYCLFSSQVFRTLSRFPPFKWFTCCCKSYRNNSQQNRCHTVGRRLHNSCDSMRTLTTSLTV 464
            .||.||.||:..:|..|     .:.|.||...|..          |.|...:..|.::.:::..:
Mouse   323 CNPWIYMLFTGHLFHEL-----VQRFLCCSARYLK----------GSRPGETSISKKSNSSTFVL 372

  Fly   465 SRRSTNKTNARVVICERPT 483
            ||||:::.:     |.:|:
Mouse   373 SRRSSSQRS-----CSQPS 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCAP-R	NP_001368957.1	7tmA_NPSR	124..416	CDD:320325	96/308 (31%)
		TM helix 1	126..150	CDD:320325	7/23 (30%)
		TM helix 2	159..182	CDD:320325	9/22 (41%)
		TM helix 3	197..219	CDD:320325	7/21 (33%)
		TM helix 4	240..256	CDD:320325	4/15 (27%)
		TM helix 5	282..305	CDD:320325	4/22 (18%)
		TM helix 6	348..370	CDD:320325	11/21 (52%)
		TM helix 7	384..409	CDD:320325	12/24 (50%)
Oxtr	NP_001074616.1	7tmA_OT_R	40..339	CDD:320509	96/308 (31%)
		TM helix 1	42..66	CDD:320509	7/23 (30%)
		TM helix 2	75..98	CDD:320509	9/22 (41%)
		TM helix 3	113..135	CDD:320509	7/21 (33%)
		TM helix 4	155..171	CDD:320509	4/15 (27%)
		TM helix 5	198..221	CDD:320509	4/22 (18%)
		TM helix 6	273..295	CDD:320509	11/21 (52%)
		TM helix 7	307..332	CDD:320509	12/27 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..388		8/38 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45270
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010