DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCAP-R and C50H11.13

DIOPT Version :9

Sequence 1:	NP_001368957.1	Gene:	CCAP-R / 2768688	FlyBaseID:	FBgn0039396	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_503838.2	Gene:	C50H11.13 / 183700	WormBaseID:	WBGene00016858	Length:	350	Species:	Caenorhabditis elegans

Alignment Length:	410	Identity:	84/410 - (20%)
Similarity:	151/410 - (36%)	Gaps:	104/410 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 IATTTASATMVQIQTTAAPSHDLETGGNSTSSDPGEFDNLNSFYFYETEQFAVLWILFTVIVLGN 141
            ::.|.|..::::..|.......||           |:.|.:...||.....::|.:...::..
Worm     1 MSVTMALQSLIKSPTLDDEQEYLE-----------EWTNSSRLLFYSVISISLLTLPILLLTF-- 52

  Fly   142 SAVLFVMFINKNRKSRMNYFIKQLA-----LADLCVGLLNVLTDIIWRITISWRAGNLACKAIRF 201
               .:::..:|.....:.|....||     |:.:.:.:|...||:::. ||   .|.|.||...|
Worm    53 ---CYILCRSKRNAHFLPYLCSILAANFVLLSTIFLSVLAKNTDLVYD-TI---PGFLVCKISTF 110

  Fly   202 ---SQVCVTYSSTYVLVAMSIDRYDAITHPMNF--SKSWKRARHLVAGAWLISALFSLPIL---- 257
               |..|..|   :..|||..:|...|..|:.|  |.|:|     .||......:||:.|.
Worm   111 LVNSSSCFIY---WTWVAMFAERCCNIFFPLRFRTSSSFK-----TAGVLCSILIFSMSIQLWTP 167

  Fly   258 VLYEEKLIQGHPQCWIELGSPIAW----QVYMSLVSATLFAIPALIISACYAIIVKTIWAKGSIF 318
            :...||.:..|.. :|..|....:    ::.:.|...|.|.:|          ::.||:|  .|.
Worm   168 IFITEKRLDNHMD-YIYCGEDPRYSSQTRIIIVLECLTTFFLP----------LILTIFA--DIS 219

  Fly   319 VPTERAGFG---------AAPARRASSRGIIPRAKVKT-------------VKMTLTIVFVFIIC 361
            |.|.::.||         ....:.:.:..|:....:|.             :..|:|: |:.:
Worm   220 VLTWKSSFGIDIDLVSREKISGKNSETMKIVSTNSLKNSKKRRSNAIRQCLISSTITL-FLNL-- 281

  Fly   362 WSPYIIFDLLQVFGQIPHSQTNIAIATFIQSLAPLNSAANPLIYCLFSSQVFRTLSRFP--PFKW 424
              |.....||..|.....|.:..|...|::        .:..:|.|:       |.:||  |.:.
Worm   282 --PNYSLQLLDEFLNFRDSNSIQARRIFLR--------IDAFVYVLY-------LMQFPITPLRM 329

  Fly   425 FTCCCKSYRNNSQQNRCHTV 444
            || ..||:.....::|.:|:
Worm   330 FT-LSKSHTRRGSRHRRNTL 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCAP-R	NP_001368957.1	7tmA_NPSR	124..416	CDD:320325	65/331 (20%)
		TM helix 1	126..150	CDD:320325	1/23 (4%)
		TM helix 2	159..182	CDD:320325	7/27 (26%)
		TM helix 3	197..219	CDD:320325	8/24 (33%)
		TM helix 4	240..256	CDD:320325	4/15 (27%)
		TM helix 5	282..305	CDD:320325	4/22 (18%)
		TM helix 6	348..370	CDD:320325	4/21 (19%)
		TM helix 7	384..409	CDD:320325	4/24 (17%)
C50H11.13	NP_503838.2	7tm_GPCRs	53..308	CDD:391938	61/284 (21%)
		TM helix 2	64..93	CDD:341315	5/28 (18%)
		TM helix 3	105..135	CDD:341315	10/32 (31%)
		TM helix 4	148..168	CDD:341315	5/19 (26%)
		TM helix 5	194..219	CDD:341315	7/36 (19%)
		TM helix 6	260..290	CDD:341315	5/34 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24224
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100