DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCAP-R and Avpr2

DIOPT Version :9

Sequence 1:	NP_001368957.1	Gene:	CCAP-R / 2768688	FlyBaseID:	FBgn0039396	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_062277.1	Gene:	Avpr2 / 12000	MGIID:	88123	Length:	371	Species:	Mus musculus

Alignment Length:	380	Identity:	117/380 - (30%)
Similarity:	181/380 - (47%)	Gaps:	32/380 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 MVQIQTTAAPSHDLETGGNSTSSDPGE-FDNLNSFYFYETEQFAVLWILFTVIVLGNSAVLFVMF 149
            |:.:.||:|....|.:..:.::|...| .|:.:....  ..:.|:|..:|..:.|.|..||..:
Mouse     1 MILVSTTSAVPGALSSPSSPSNSSQEELLDDRDPLLV--RAELALLSTIFVAVALSNGLVLGAL- 62

  Fly   150 INKNRKSR---MNYFIKQLALADLCVGLLNVLTDIIWRITISWRAGNLACKAIRFSQVCVTYSST 211
            |.:.|:.|   |:.||..|.||||.|.|..||..:.|..|..:...:..|:|:::.|:...|:|:
Mouse    63 IRRGRRGRWAPMHVFISHLCLADLAVALFQVLPQLAWDATDRFHGPDALCRAVKYLQMVGMYASS 127

  Fly   212 YVLVAMSIDRYDAITHPM-----NFSKSWKRARHLVAGAWLISALFSLPILVLYEEKLI---QGH 268
            |:::||::||:.||..||     .....|.|.   |..||..|.|.|||.|.::.::.:   .|.
Mouse   128 YMILAMTLDRHRAICRPMLAYRHGGGARWNRP---VLVAWAFSLLLSLPQLFIFAQRDVGNGSGV 189

  Fly   269 PQCWIELGSPIAWQVYMSLVSATLFAIPALIISACYAIIVKTIWAKGSIFVPTERAGFGAAPARR 333
            ..||.....|...:.|::.::..:|..|||.|:||..:|.:.|.| ..:..|:||||......|.
Mouse   190 FDCWARFAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHA-SLVPGPSERAGRRRRGHRT 253

  Fly   334 AS-SRGI-IPRAKVKTVKMTLTIVFVFIICWSPYIIFDLLQVFGQIPHSQTNIAIATFIQSLAPL 396
            .| |.|. :..|..|||:|||.||.|:::||:|:.:..|...:.  |.:.........:..||.|
Mouse   254 GSPSEGAHVSAAMAKTVRMTLVIVIVYVLCWAPFFLVQLWAAWD--PEAPLERPPFVLLMLLASL 316

  Fly   397 NSAANPLIYCLFSSQVFRTLSRFPPFKWFTCCCKSYRNNS---QQNRCHTVGRRL 448
            ||..||.||..|||.|...|      :...||.:.:..:|   |...|.|....|
Mouse   317 NSCTNPWIYASFSSSVSSEL------RSLLCCAQRHTTHSLGPQDESCATASSSL 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCAP-R	NP_001368957.1	7tmA_NPSR	124..416	CDD:320325	101/304 (33%)
		TM helix 1	126..150	CDD:320325	7/23 (30%)
		TM helix 2	159..182	CDD:320325	11/22 (50%)
		TM helix 3	197..219	CDD:320325	7/21 (33%)
		TM helix 4	240..256	CDD:320325	7/15 (47%)
		TM helix 5	282..305	CDD:320325	8/22 (36%)
		TM helix 6	348..370	CDD:320325	10/21 (48%)
		TM helix 7	384..409	CDD:320325	9/24 (38%)
Avpr2	NP_062277.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27		6/25 (24%)
		7tmA_V2R	38..326	CDD:320510	96/294 (33%)
		TM helix 1	39..65	CDD:320510	8/26 (31%)
		TM helix 2	74..101	CDD:320510	13/26 (50%)
		TM helix 3	112..142	CDD:320510	11/29 (38%)
		TM helix 4	155..176	CDD:320510	10/23 (43%)
		TM helix 5	202..231	CDD:320510	9/28 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	240..259		8/18 (44%)
		TM helix 6	264..294	CDD:320510	14/29 (48%)
		TM helix 7	304..326	CDD:320510	8/21 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	349..371		5/17 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6043
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3458
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.980