DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CCAP-R and avpr2.2

DIOPT Version :9

Sequence 1:	NP_001368957.1	Gene:	CCAP-R / 2768688	FlyBaseID:	FBgn0039396	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	XP_002932869.2	Gene:	avpr2.2 / 100489955	XenbaseID:	XB-GENE-1219042	Length:	364	Species:	Xenopus tropicalis

Alignment Length:	378	Identity:	121/378 - (32%)
Similarity:	180/378 - (47%)	Gaps:	56/378 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 NSFYFYE----TEQFA-----VLWILFTVIVLGNSAVLFVMFINKNRKSRMNYFIKQLALADLCV 172
            |...|.|    :||.|     ||.::|.|...||..::.|::..:.:.|||..|:..|:||||.|
Frog    22 NKSQFIERPDRSEQLAYVEISVLGVIFMVASAGNLTLILVLWNKRKKLSRMYVFMLHLSLADLVV 86

  Fly   173 GLLNVLTDIIWRITISWRAGNLACKAIRFSQVCVTYSSTYVLVAMSIDRYDAITHPM-NFSKSWK 236
            ....||..:||.||..:...:..|:.||:.|:...::|||::|.|::||:.||.:|| .|.|  |
Frog    87 AFFQVLPQMIWDITDVFFGPDPMCRLIRYLQLVGMFASTYMIVVMTLDRFQAICYPMVTFQK--K 149

  Fly   237 RA--RHLVAGAWLISALFSLP-ILVLYEEKLIQGHPQCWIELGSPIAWQVYMSLVSATLFAIPAL 298
            ||  ...:..:|.||.|||:| :.:..:.::..|..:||.:...|...:.|::.:...:|.||..
Frog   150 RALWNAPICASWCISLLFSIPQVFIFSKTEIYPGIFECWAKFMEPWGSKAYVTWIFVAIFFIPIN 214

  Fly   299 IISACYAIIVKTIWAKGSIFVP-------TERAGFGAAPARRASSRGIIPRAKVKTVKMTLTIVF 356
            |:..|...|.:||  |.:|:|.       .|:...||:   ||||...|.:|.:||||||:..|.
Frog   215 ILIVCQIKICRTI--KTNIYVKQHSDLELQEQHRIGAS---RASSINCISKAMIKTVKMTVVTVV 274

  Fly   357 VFIICWSPYIIFDLLQVFGQIPHSQTNIAIATFIQSLAPLNSAANPLIYCLFSSQVFRTLSRFPP 421
            .|.:||:|:.|..|...:..  ...|..|..|.|..|..|||.|||.||..||..:.|
Frog   275 AFFLCWTPFFIVHLWVAWSS--EDVTEGAAFTIIMLLGNLNSCANPWIYMYFSGHIPR------- 330

  Fly   422 FKWFTCCCKSYRNNSQQNRCHTVGRRLHNSCDSMRTLTTSLTVSRRSTNKTNA 474
                   |.|:|..            |....||:.|.:..|. .|...::|.|
Frog   331 -------CVSHRET------------LSTREDSLNTASIDLG-DRDCEDRTTA 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CCAP-R	NP_001368957.1	7tmA_NPSR	124..416	CDD:320325	107/307 (35%)
		TM helix 1	126..150	CDD:320325	9/28 (32%)
		TM helix 2	159..182	CDD:320325	9/22 (41%)
		TM helix 3	197..219	CDD:320325	8/21 (38%)
		TM helix 4	240..256	CDD:320325	7/16 (44%)
		TM helix 5	282..305	CDD:320325	6/22 (27%)
		TM helix 6	348..370	CDD:320325	10/21 (48%)
		TM helix 7	384..409	CDD:320325	12/24 (50%)
avpr2.2	XP_002932869.2	7tm_GPCRs	39..331	CDD:391938	104/314 (33%)
		TM helix 1	40..64	CDD:341315	7/23 (30%)
		TM helix 2	73..96	CDD:341315	9/22 (41%)
		TM helix 3	111..133	CDD:341315	8/21 (38%)
		TM helix 4	155..171	CDD:341315	6/15 (40%)
		TM helix 5	198..221	CDD:341315	6/22 (27%)
		TM helix 6	263..288	CDD:341315	12/24 (50%)
		TM helix 7	300..325	CDD:341315	12/24 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45270
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010