DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LpR1 and Lrp1b

DIOPT Version :10

Sequence 1:NP_001097934.2 Gene:LpR1 / 2768687 FlyBaseID:FBgn0066101 Length:1076 Species:Drosophila melanogaster
Sequence 2:XP_006498522.1 Gene:Lrp1b / 94217 MGIID:2151136 Length:4668 Species:Mus musculus


Alignment Length:812 Identity:314/812 - (38%)
Similarity:441/812 - (54%) Gaps:79/812 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly   144 HSGDC------IPIRFVCDGDADCKDHS--DEQIKECKFIEA-----TCSSDQFRCGNGNCIPNK 195
            ::|.|      ||...||    .|.|:.  ||....|.|...     .|...:|||.|.:||..:
Mouse   832 NNGGCGTLCLAIPAGRVC----ACADNQLLDENGTTCTFNPEEIRFHICKPGEFRCKNKHCIQAR 892

  Fly   196 WRCDQESDCADGSDEANELCMN-ACPNNEFKCQTVDQCIPRSWLCDGSNDCRDKSDEAH--CRAR 257
            |:||.:.||.|||||.:..|.| :||:::||||. ::|||:.|||||:|||....||::  |.||
Mouse   893 WKCDGDDDCLDGSDEDSVTCFNHSCPDDQFKCQN-NRCIPKRWLCDGANDCGSNEDESNQTCTAR 956

  Fly   258 TCSPDEYACKSGEGQCVPLAWMCDQSKDCSDGSDE-HNCN-QTCR-ADEFTCGNGRCIQKRWKCD 319
            ||..|:::|  |.|:|:|.||:||:..||.|.:|| .:|. .||. ..:|.|.:||||..:|.||
Mouse   957 TCQADQFSC--GNGRCIPTAWLCDREDDCGDQTDEVASCEFPTCEPLTQFICKSGRCISNKWHCD 1019

  Fly   320 HDDDCGDGSDEKECPVVPCDSVAEHTCTNGACIAKRWVCDGDPDCSDGSDERSCANVTK----TT 380
            .||||||.|||..|.....|.  :..|::|.||...|.||||.||.|.||| :..|.||    :.
Mouse  1020 TDDDCGDRSDEVGCVHSCLDD--QFRCSSGRCIPGHWACDGDNDCGDFSDE-THINCTKEEARSP 1081

  Fly   381 TPCLSHEYQCKDRITCLHHSWLCDGDRDCPDGDDEHTAN-----CKNVTCRADQFQCGDRS---C 437
            ..|:.:|:||:....|:...|.|||::||.||.||...|     |.:.|    :|.|  ||   |
Mouse  1082 AGCIGNEFQCRPDGNCIPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKT----KFSC--RSTGRC 1140

  Fly   438 IPGHLTCNGDKDCADGSDERDCGLSLSLGINQGGC-NATSEFDCGGGQCVPLSKVCDKRKDCPDG 501
            |.....|:||.||.|.|||.||. |...|..:..| |.||       .|:...|:|:.|||||||
Mouse  1141 INNAWVCDGDVDCEDQSDEEDCD-SFLCGPPKYPCANDTS-------VCLQPEKLCNGRKDCPDG 1197

  Fly   502 EDEPAGKCGINECASKNGGCMHQC-IDLKVGHHCECHEGYKLSPDKRNCQDINECEVPGKCSQIC 565
            .|| ...|  :||:..||||.:.| :....|..|.|.||::|..|.|.|:.::.|....:|||:|
Mouse  1198 SDE-GDLC--DECSLNNGGCSNHCSVVPGRGIVCSCPEGHQLKKDNRTCEIVDYCASHLRCSQVC 1259

  Fly   566 VNEIGGFKCECEAGYMRDPKNHTRCKASEGHASLLLARRHDIRKIALDHMEMTSIVNSTKAATAL 630
            ..:....||.|..|:.......:........|.::.:.||:||:|.|...:.:.:|...:...||
Mouse  1260 EQQKHMVKCSCYEGWALGTDGESCTSVDSFEAFIIFSIRHEIRRIDLHKGDYSLLVPGLRNTIAL 1324

  Fly   631 DFVFRTGMIFWSDVTTQSIYKAPIDEGNEKT---VVLTKSSVTSDGLAVDWIYNHVYFTDTHKCT 692
            ||.|...:::|:||....||:..:.|....:   ||:.....|.:||.||||..::|:.|::...
Mouse  1325 DFHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQ 1389

  Fly   693 IELTNFEGSMGKVLVKDSLDIPRSIALDPIEGWMYWSDWGAS-PRIERAGMDGSHRTTIISYDVK 756
            ||::..:||:...|:..:::.||:|||||..|.::|:||.|: ||||.|.|.|:.|.||.. |:|
Mouse  1390 IEVSKLDGSLRATLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYK-DMK 1453

  Fly   757 ---WPNGITLDLVKKRIYWVDGKLNVISSANYDGSQRSQVLYSGEYLRHPFSITTFEDNVYWTDW 818
               ||||:|:|..::||.|.|.:.:.|.||.|||:...:::...|||.|||:::.:...||||||
Mouse  1454 TGAWPNGLTVDHFERRIVWTDARSDAIYSAFYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDW 1518

  Fly   819 DKQAVFKANKFTGEDVEPVTAMHMLQHPMVVHVYHPYRQPDGVNHCQSVNGH--CSHLCLPAPRI 881
            ....:.||||:||::|..:  ......|..:.:|||.|||...|.|.:..|.  ||||||    |
Mouse  1519 RTNTLAKANKWTGQNVSVI--QKTSAQPFDLQIYHPSRQPQAPNPCAANEGRGPCSHLCL----I 1577

  Fly   882 N-ERSPRISCACPTGLKLMVDGLMCVEDPLYL 912
            | .||  .:||||..:||..|...|.|...:|
Mouse  1578 NHNRS--AACACPHLMKLSSDKKTCYEMKKFL 1607

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LpR1NP_001097934.2 LDLa 135..167 CDD:197566 8/30 (27%)
LDLa 178..210 CDD:197566 15/31 (48%)
LDLa 219..254 CDD:238060 19/36 (53%)
LDLa 259..295 CDD:238060 16/36 (44%)
LDLa 343..373 CDD:238060 15/29 (52%)
LDLa 383..415 CDD:197566 13/31 (42%)
Ldl_recept_a 423..459 CDD:395011 16/38 (42%)
LDLa 476..504 CDD:197566 11/27 (41%)
FXa_inhibition 514..549 CDD:464251 14/35 (40%)
EGF_CA 551..581 CDD:214542 9/29 (31%)
LY 662..702 CDD:214531 14/39 (36%)
LY 704..747 CDD:214531 20/43 (47%)
LY 749..790 CDD:214531 20/43 (47%)
Ldl_recept_b 769..815 CDD:459654 17/45 (38%)
FXa_inhibition 864..905 CDD:464251 19/43 (44%)
Lrp1bXP_006498522.1 LDLa 63..95 CDD:238060
LDLa 107..140 CDD:197566
FXa_inhibition 194..224 CDD:464251
LY 314..346 CDD:214531
LY 350..392 CDD:214531
LY 394..435 CDD:214531
FXa_inhibition 506..547 CDD:464251
Ldl_recept_b 599..639 CDD:459654
LY 622..661 CDD:214531
LY 668..717 CDD:214531
LY 718..760 CDD:214531
FXa_inhibition 829..864 CDD:464251 10/35 (29%)
LDLa 917..950 CDD:238060 19/33 (58%)
LDLa 957..989 CDD:197566 15/33 (45%)
LDLa 1000..1033 CDD:238060 18/32 (56%)
LDLa 1037..1070 CDD:238060 16/35 (46%)
LDLa 1084..1119 CDD:238060 15/34 (44%)
Ldl_recept_a 1131..1162 CDD:395011 15/32 (47%)
LDLa 1167..1202 CDD:238060 17/42 (40%)
FXa_inhibition 1207..1243 CDD:464251 14/35 (40%)
YncE 1313..1537 CDD:442618 87/224 (39%)
LY 1358..1398 CDD:214531 13/39 (33%)
LY 1402..1445 CDD:214531 20/42 (48%)
Ldl_recept_b 1649..1689 CDD:459654
LY 1672..1714 CDD:214531
Ldl_recept_b 1736..1773 CDD:459654
LY <1766..1797 CDD:214531
FXa_inhibition 1869..1905 CDD:464251
NHL 1944..2169 CDD:302697
NHL repeat 1944..1983 CDD:271320
LY 1978..2018 CDD:214531
NHL repeat 1988..2025 CDD:271320
NHL repeat 2029..2070 CDD:271320
Ldl_recept_b 2039..2080 CDD:459654
LY 2064..2106 CDD:214531
NHL repeat 2073..2111 CDD:271320
NHL repeat 2120..2159 CDD:271320
FXa_inhibition 2178..2213 CDD:464251
Ldl_recept_b 2361..2403 CDD:459654
LY 2386..2428 CDD:214531
LDLa 2545..2574 CDD:238060
LDLa 2583..2617 CDD:238060
LDLa 2622..2656 CDD:238060
LDLa 2676..2705 CDD:238060
LDLa 2713..2747 CDD:238060
LDLa 2751..2784 CDD:238060
LDLa 2791..2824 CDD:197566
LDLa 2875..2908 CDD:197566
LDLa 2922..2956 CDD:238060
FXa_inhibition 2968..2997 CDD:464251
EGF_CA 2999..3033 CDD:214542
LY 3066..3110 CDD:214531
LY 3111..3149 CDD:214531
LY 3154..3195 CDD:214531
LY 3198..3237 CDD:214531
FXa_inhibition 3308..3344 CDD:464251
LDLa 3348..3379 CDD:197566
LDLa 3388..3422 CDD:238060
LDLa 3427..3462 CDD:238060
LDLa 3467..3502 CDD:238060
LDLa 3507..3541 CDD:238060
LDLa 3546..3580 CDD:238060
LDLa 3584..3618 CDD:238060
LDLa 3625..3659 CDD:238060
LDLa 3663..3698 CDD:238060
LDLa 3705..3737 CDD:238060
LDLa 3746..3782 CDD:238060
LDLa 3793..3827 CDD:238060
EGF_CA 3875..3909 CDD:214542
NHL 3972..4204 CDD:302697
NHL repeat 4002..4039 CDD:271320
NHL repeat 4060..4098 CDD:271320
Ldl_recept_b 4070..4111 CDD:459654
LY 4094..4133 CDD:214531
NHL repeat 4148..4186 CDD:271320
EGF_CA 4281..4315 CDD:238011
Blue background indicates that the domain is not in the aligned region.

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