DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LpR1 and Lrp4

DIOPT Version :9

Sequence 1:NP_001097934.2 Gene:LpR1 / 2768687 FlyBaseID:FBgn0066101 Length:1076 Species:Drosophila melanogaster
Sequence 2:NP_112612.2 Gene:Lrp4 / 83469 RGDID:619731 Length:1905 Species:Rattus norvegicus


Alignment Length:786 Identity:331/786 - (42%)
Similarity:423/786 - (53%) Gaps:89/786 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   127 GIGQSLEAKCDEKQFQCHSG-----DCIPIRFVCDGDADCKDHSDEQIKECKFIEATCSSDQFRC 186
            |...:||..|....|.|...     .|||.::.||||.||.|||||.  .|..  .|||...|.|
  Rat    18 GTASNLECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDED--GCTL--PTCSPLDFHC 78

  Fly   187 GNGNCIPNKWRCDQESDCADGSDEANELC-MNACPNNEFKCQTVDQCIPRSWLCDGSNDCRDKSD 250
            .||.||...|.||.::||.|.|||.:  | ...|..:||.||. ..||...|.|||.|||.|.||
  Rat    79 DNGKCIRRSWVCDGDNDCEDDSDEQD--CPPRECEEDEFPCQN-GYCIRSLWHCDGDNDCGDNSD 140

  Fly   251 EAHCRARTCSPDEYACKSGEGQCVPLAWMCDQSKDCSDGSDEHNC-----NQTCRADEFTCGNGR 310
            | .|..|.||..|:.|  .:|.|:...|.||...||.|||||.:|     :..|..:||.|..||
  Rat   141 E-QCDMRKCSDKEFRC--SDGSCIAEHWYCDGDTDCKDGSDEESCPSAVPSPPCNLEEFQCAYGR 202

  Fly   311 CIQKRWKCDHDDDCGDGSDEKECPV-VPCDSVAEHTCTNGACIAKRWVCDGDPDCSDGSDERSCA 374
            .|...:.||.||||||.|||.:|.. .||.| .|..|.:|.|:...|.||||.||.|.||||:| 
  Rat   203 RILDIYHCDGDDDCGDWSDESDCSSHQPCRS-GEFMCDSGLCVNAGWRCDGDADCDDQSDERNC- 265

  Fly   375 NVTKTTTPCLSHEYQCKDRITCLHHSWLCDGDRDCPDGDDEHTANCKNV---TCRADQFQCGDRS 436
                ||:.|.:.:::|:.. .|:..||.|||:.||.|..||.  ||:|.   .|.:|||.|.:..
  Rat   266 ----TTSMCTAEQFRCRSG-RCVRLSWRCDGEDDCADNSDEE--NCENTGSPQCASDQFLCWNGR 323

  Fly   437 CIPGHLTCNGDKDCADGSDERDCGLSLSLGINQGGCNATSEFDCGGGQCVPLSKVCDKRKDCPDG 501
            ||.....|||..||.|.|||..          |..|...:                        |
  Rat   324 CIGQRKLCNGVNDCGDNSDESP----------QQNCRPRT------------------------G 354

  Fly   502 EDEPAGKCGINECASKNGGCMHQCIDLKVGHHCECHEGYKLSPDKRNCQDINECEVPGKCSQICV 566
            |:    .|.:|     ||||..:|..::....|.||.||:|:.|.|.|||:|||...|.|||.|.
  Rat   355 EE----NCNVN-----NGGCAQKCQMIRGAVQCTCHTGYRLTEDGRTCQDVNECAEEGYCSQGCT 410

  Fly   567 NEIGGFKCECEAGYMRDPKNHTRCKASEGHASLLLARRHDIRKIALDHMEMTSIVNSTKAATALD 631
            |..|.|:|.|||||...|...: |||......||.|.|.|||::.....|.|.::|:.:.|.|||
  Rat   411 NSEGAFQCWCEAGYELRPDRRS-CKALGPEPVLLFANRIDIRQVLPHRSEYTLLLNNLENAIALD 474

  Fly   632 FVFRTGMIFWSDVTTQSIYKAPIDEGNEKTVVLTKSSVTSDGLAVDWIYNHVYFTDTHKCTIELT 696
            |..|..::||||||...|.:|.::..|.:.||.| ...:..||||||:::.:|:||:....||:.
  Rat   475 FHHRRELVFWSDVTLDRILRANLNGSNVEEVVST-GLESPGGLAVDWVHDKLYWTDSGTSRIEVA 538

  Fly   697 NFEGSMGKVLVKDSLDIPRSIALDPIEGWMYWSDWGASPRIERAGMDGSHRTTIISYDVKWPNGI 761
            |.:|:..|||:..||:.||:|||.|:||.:||:|||.:||||.:.||||.|..|....:.||||:
  Rat   539 NLDGAHRKVLLWQSLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGL 603

  Fly   762 TLDLVKKRIYWVDGKLNVISSANYDGSQRSQVLYSGEYLRHPFSITTFEDNVYWTDWDKQAVFKA 826
            |:|...:|:||||.|.:||..||.|||.|..|:..|  |.|||:||.|||::|||||..:::..|
  Rat   604 TIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQG--LPHPFAITVFEDSLYWTDWHTKSINSA 666

  Fly   827 NKFTGEDVEPVTAMHMLQHPMVVHVYHPYRQPDGVNHCQSVNGHCSHLCLPAPRINERSPRISCA 891
            |||||::.|.:  .:.|..||.:|..||.|||.|.|.|...||.|:|||||:      ....:||
  Rat   667 NKFTGKNQEII--RNKLHFPMDIHTLHPQRQPAGKNRCGDNNGGCTHLCLPS------GQNYTCA 723

  Fly   892 CPTGLK 897
            ||||.:
  Rat   724 CPTGFR 729

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LpR1NP_001097934.2 LDLa 135..167 CDD:197566 15/36 (42%)
LDLa 178..210 CDD:197566 16/31 (52%)
LDLa 219..254 CDD:238060 18/34 (53%)
LDLa 259..295 CDD:238060 16/35 (46%)
LDLa 343..373 CDD:238060 16/29 (55%)
LDLa 383..415 CDD:197566 11/31 (35%)
Ldl_recept_a 423..459 CDD:278486 16/38 (42%)
LDLa 476..504 CDD:197566 2/27 (7%)
FXa_inhibition 514..549 CDD:291342 13/34 (38%)
EGF_CA 551..581 CDD:214542 17/29 (59%)
LY 662..702 CDD:214531 16/39 (41%)
LY 704..747 CDD:214531 26/42 (62%)
LY 749..790 CDD:214531 20/40 (50%)
FXa_inhibition 864..905 CDD:291342 15/34 (44%)
Lrp4NP_112612.2 LDLa 27..66 CDD:238060 17/40 (43%)
Ldl_recept_a 70..105 CDD:278486 18/36 (50%)
LDLa 110..142 CDD:238060 18/33 (55%)
LDLa 148..182 CDD:238060 16/35 (46%)
LDLa 231..265 CDD:238060 18/34 (53%)
LDLa 270..304 CDD:238060 13/36 (36%)
LDLa 311..343 CDD:197566 14/31 (45%)
FXa_inhibition 358..393 CDD:291342 15/39 (38%)
EGF_CA 395..434 CDD:214542 19/39 (49%)
NHL <471..622 CDD:302697 70/151 (46%)
NHL repeat 471..507 CDD:271320 15/35 (43%)
LDL-receptor class B 1 480..522 18/42 (43%)
LY 505..545 CDD:214531 16/40 (40%)
NHL repeat 510..550 CDD:271320 16/39 (41%)
LDL-receptor class B 2 523..565 18/41 (44%)
NHL repeat 555..589 CDD:271320 21/33 (64%)
LDL-receptor class B 3 566..609 22/42 (52%)
LY 590..632 CDD:214531 20/41 (49%)
NHL repeat 598..622 CDD:271320 12/23 (52%)
LDL-receptor class B 4 610..652 24/43 (56%)
LY 633..673 CDD:214531 22/41 (54%)
LDL-receptor class B 5 653..693 17/41 (41%)
FXa_inhibition 702..>729 CDD:291342 15/32 (47%)
LY 766..806 CDD:214531
LDL-receptor class B 6 785..827
LY 808..850 CDD:214531
LDL-receptor class B 7 828..870
LDL-receptor class B 8 871..914
Ldl_recept_b 871..911 CDD:278487
LY 895..937 CDD:214531
LDL-receptor class B 9 915..956
LY 938..979 CDD:214531
LDL-receptor class B 10 957..998
FXa_inhibition 1006..1043 CDD:291342
NHL <1085..1277 CDD:302697
NHL repeat 1085..1123 CDD:271320
LDL-receptor class B 11 1093..1135
NHL repeat 1128..1161 CDD:271320
LDL-receptor class B 12 1136..1178
NHL repeat 1166..1203 CDD:271320
LDL-receptor class B 13 1179..1222
NHL repeat 1212..1244 CDD:271320
LDL-receptor class B 14 1223..1263
NHL repeat 1253..1277 CDD:271320
LDL-receptor class B 15 1264..1306
FXa_inhibition 1313..1348 CDD:291342
LY 1379..1418 CDD:214531
LDL-receptor class B 16 1397..1439
LY 1420..1460 CDD:214531
LDL-receptor class B 17 1440..1482
LDL-receptor class B 18 1483..1526
Ldl_recept_b 1483..1523 CDD:278487
LY 1507..1547 CDD:214531
LDL-receptor class B 19 1527..1568
LY 1549..1589 CDD:214531
LDL-receptor class B 20 1569..1610
FXa_inhibition 1617..>1641 CDD:291342
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1659..1696
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1853..1905
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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