DRSC/TRiP Functional Genomics Resources

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Protein Alignment LpR1 and LRP8

DIOPT Version :9

Sequence 1:NP_001097934.2 Gene:LpR1 / 2768687 FlyBaseID:FBgn0066101 Length:1076 Species:Drosophila melanogaster
Sequence 2:XP_005271230.1 Gene:LRP8 / 7804 HGNCID:6700 Length:976 Species:Homo sapiens


Alignment Length:956 Identity:345/956 - (36%)
Similarity:493/956 - (51%) Gaps:116/956 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   125 PLGIGQSLEAKCDEKQFQCHSGDCIPIRFVCDGDADCKDHSDEQIKECKFIEATCSSDQFRCGNG 189
            ||..||.....|::.||||.:..|||..:.||.|.||.|||||.  :|.  :.||:...|.|.||
Human    36 PLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDED--DCP--KKTCADSDFTCDNG 96

  Fly   190 NCIPNKWRCDQESDCADGSDEANELCMNACPNNEFKCQTVDQCIPRSWLCDGSNDCRDKSDEAHC 254
            :||..:|:||.|.:|.|||||:                                       ||.|
Human    97 HCIHERWKCDGEEECPDGSDES---------------------------------------EATC 122

  Fly   255 RARTCSPDEYACKSGEGQCVPLAWMCDQSKDCSDGSDEHNCNQTCRADEFTCGNGRCIQKRWKCD 319
            ..:.|..::.:|.....:|||.:|.||..|||..|:||..|...|...||.|||..|:...:.||
Human   123 TKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCD 187

  Fly   320 HDDDCGDGSDEKECPVVPCDSVAEHTC---TNGACIAKRWVCDGDPDCSDGSDE------RSCAN 375
            .||||||||||:.|....| ...|..|   ..||||.:|||||...||.|.|||      |....
Human   188 GDDDCGDGSDERGCADPAC-GPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPG 251

  Fly   376 VTKTTTPC-LSHEYQCKDRITCLHHSWLCDGDRDCPDGDDEHTANCKNVTCRADQFQCGDRSCIP 439
            .|.....| .:.::.|:.. .|:|..|.|||||||.|..||  |:|...|||.|:|||||.:|:.
Human   252 ATSAPAACATASQFACRSG-ECVHLGWRCDGDRDCKDKSDE--ADCPLGTCRGDEFQCGDGTCVL 313

  Fly   440 GHLTCNGDKDCADGSDERDCGLSLSLGINQGGCNATSEFDCGGGQCVPLSKVCDKRKDCPDGEDE 504
            ....||.::||.|||||..|                        ..||.:.:.::|:        
Human   314 AIKHCNQEQDCPDGSDEAGC------------------------LQVPPTFLGNRRR-------- 346

  Fly   505 PAGKCGINECASKNGGCMHQCIDLKVGHHCECHEGYKLSPDKRNCQDINECEVPGKCSQICVNEI 569
            |.   |:|||...||||.|.|.|||:|..|.|..|::|. |::.|.||:||:.|..|||||||..
Human   347 PR---GLNECLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQKTCGDIDECKDPDACSQICVNYK 407

  Fly   570 GGFKCECEAGYMRD--PKNHTRCKASEGHA-SLLLARRHDIRKIALDHMEMTSIVNSTKAATALD 631
            |.|||||..||..|  .||   |||:.|.: ||:...||::|:|.|.....:.::...|...|||
Human   408 GYFKCECYPGYEMDLLTKN---CKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALD 469

  Fly   632 FVFRTGMIFWSDVTTQSIYKAPIDEGN---EKTVVLTKSSVTSDGLAVDWIYNHVYFTDTHKCTI 693
            ....|..|:|.|::.:.||.|.:|:.:   |:.|::.:...:.:||||||::.|:|:||:...||
Human   470 VEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTI 534

  Fly   694 ELTNFEGSMGKVLVKDSLDIPRSIALDPIEGWMYWSDWGASPRIERAGMDGSHRTTIISYDVKWP 758
            .:...:|...:.|...:|..||:||:||:.|:|||||||...:||::|::|..|.|::|.:::||
Human   535 SVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWP 599

  Fly   759 NGITLDLVKKRIYWVDGKLNVISSANYDGSQRSQVLYSGEYLRHPFSITTFEDNVYWTDWDKQAV 823
            |||||||:.:|:||||.||:.:||.::.|..|..::.|.::|.|||.|..|||.|:|||.:.:|:
Human   600 NGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAI 664

  Fly   824 FKANKFTGEDVEPVTAMHMLQHPMVVHVYHPYRQPDGVNHCQ-SV--NGHCSHLCLPAPRINERS 885
            |.||:..|.::..:.  ..|.:|..:.::|..:||...:.|: ||  ||.|.:||||||:|:..|
Human   665 FSANRLNGLEISILA--ENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHS 727

  Fly   886 PRISCACPTGLKLMVDGLMCVEDPLYLPPVTRPPRARKTKP-RPKSPRRRLPTGVQVGHADIRIE 949
            |:.:||||..:.|..|...|...|......|......:|.| ..::|...:.......|:.....
Human   728 PKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPS 792

  Fly   950 INDDLQLSTRLPLLPTTFVADQRP-VKNHTQIEKTTTPSEQPDSGFIALVVIASLSGFAVLLSVL 1013
            :...:..|..:|..|:...:...| ..||:|    ...:|....|......:..:....|::::|
Human   793 LTAAVPSSVSVPRAPSISPSTLSPATSNHSQ----HYANEDSKMGSTVTAAVIGIIVPIVVIALL 853

  Fly  1014 LLIGY---RYCSKRRINSMNFENPIYRKTTTTEDHFSLRKNLPARI 1056
            .:.||   |...::...||||:||:|||||..||...|.....|:|
Human   854 CMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQI 899

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LpR1NP_001097934.2 LDLa 135..167 CDD:197566 16/31 (52%)
LDLa 178..210 CDD:197566 16/31 (52%)
LDLa 219..254 CDD:238060 2/34 (6%)
LDLa 259..295 CDD:238060 14/35 (40%)
LDLa 343..373 CDD:238060 18/38 (47%)
LDLa 383..415 CDD:197566 13/32 (41%)
Ldl_recept_a 423..459 CDD:278486 19/35 (54%)
LDLa 476..504 CDD:197566 3/27 (11%)
FXa_inhibition 514..549 CDD:291342 16/34 (47%)
EGF_CA 551..581 CDD:214542 19/29 (66%)
LY 662..702 CDD:214531 14/39 (36%)
LY 704..747 CDD:214531 20/42 (48%)
LY 749..790 CDD:214531 21/40 (53%)
FXa_inhibition 864..905 CDD:291342 21/43 (49%)
LRP8XP_005271230.1 LDLa 47..81 CDD:238060 18/35 (51%)
LDLa 85..117 CDD:197566 16/31 (52%)
LDLa 127..163 CDD:238060 14/35 (40%)
LDLa 206..240 CDD:197566 16/34 (47%)
Ldl_recept_a 262..294 CDD:278486 15/34 (44%)
Ldl_recept_a 298..333 CDD:278486 19/34 (56%)
FXa_inhibition 353..387 CDD:291342 16/34 (47%)
EGF_CA 389..419 CDD:214542 19/29 (66%)
LY 458..493 CDD:214531 11/34 (32%)
LY 502..544 CDD:214531 14/41 (34%)
Ldl_recept_b 565..605 CDD:278487 21/39 (54%)
LY 589..631 CDD:214531 21/41 (51%)
Ldl_recept_b 652..691 CDD:278487 12/40 (30%)
FXa_inhibition 710..747 CDD:291342 18/36 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 713 1.000 Inparanoid score I644
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG49125
OrthoDB 1 1.010 - - D179614at33208
OrthoFinder 1 1.000 - - FOG0002088
OrthoInspector 1 1.000 - - mtm8553
orthoMCL 1 0.900 - - OOG6_103130
Panther 1 1.100 - - O PTHR24270
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R7933
SonicParanoid 1 1.000 - - X1052
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1111.010

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