DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LpR1 and VLDLR

DIOPT Version :9

Sequence 1:	NP_001097934.2	Gene:	LpR1 / 2768687	FlyBaseID:	FBgn0066101	Length:	1076	Species:	Drosophila melanogaster
Sequence 2:	NP_003374.3	Gene:	VLDLR / 7436	HGNCID:	12698	Length:	873	Species:	Homo sapiens

Alignment Length:	966	Identity:	366/966 - (37%)
Similarity:	514/966 - (53%)	Gaps:	129/966 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 SGKIGTPLGIGQSLEAKCDEKQFQCHSGDCIPIRFVCDGDADCKDHSDEQIKECKFIEATCSSDQ 183
            ||..||      ..:|||:..||||.:|.||.:.:.||||.||.|.|||  |.|  ::.||:...
Human    22 SGATGT------GRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDE--KNC--VKKTCAESD 76

  Fly   184 FRCGNGNCIPNKWRCDQESDCADGSDEANELCMNACPNNEFKCQTVDQCIPRSWLCDGSNDCRDK 248
            |.|.||.|:|::|:||.:.||.|||||:.|
Human    77 FVCNNGQCVPSRWKCDGDPDCEDGSDESPE----------------------------------- 106

  Fly   249 SDEAHCRARTCSPDEYACKSGEGQCVPLAWMCDQSKDCSDGSDEHNC-NQTCRADEFTCGNGRCI 312
                .|..|||...|.:|.:...||:|::|.||...||..|.||.|| |.||..|||||.:||||
Human   107 ----QCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCI 167

  Fly   313 QKRWKCDHDDDCGDGSDEKECPVVPCDSVAEHTCTNGACIAKRWVCDGDPDCSDGSDE--RSCAN 375
            .:.:.|:..|||.|||||.:|....| ...|..|:..:||...||||.|.||||.|||  ..|..
Human   168 SRNFVCNGQDDCSDGSDELDCAPPTC-GAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGR 231

  Fly   376 VTKTTTPCLSHEYQCKDRITCLHHSWLCDGDRDCPDGDDEHTANCKNVTCRADQFQCGDRSCIPG 440
            .....|.|.:.|.||... .|:|..|.||||.||.||.||  .||.:.|||.|||:|.|.|||.|
Human   232 QPVIHTKCPASEIQCGSG-ECIHKKWRCDGDPDCKDGSDE--VNCPSRTCRPDQFECEDGSCIHG 293

  Fly   441 HLTCNGDKDCADGSDERDCGLSLSLGINQGGCNATSEFDCGGGQCVPLSKVCDKRKDCPDGEDEP 505
            ...|||.:||.|||||.:|     ..:||  |....:|.|..|:|:.:||||::.:||.|..|||
Human   294 SRQCNGIRDCVDGSDEVNC-----KNVNQ--CLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEP 351

  Fly   506 AGKCGINECASKNGGCMHQCIDLKVGHHCECHEGYKLSPDKRNCQDINECEVPGKCSQICVNEIG 570
            ..:|.||||...||||.|.|.||.:|:.|:|..|::|. |::.|.||:||:.||.|||||:|..|
Human   352 LKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELI-DRKTCGDIDECQNPGICSQICINLKG 415

  Fly   571 GFKCECEAGYMRDPKNHTRCKASEGHASLLLARRHDIRKIALDHMEMTSIVNSTKAATALDFVFR 635
            |:||||..||..|..... |||.....||:...|.|||||.|:..|...:|...:...|||....
Human   416 GYKCECSRGYQMDLATGV-CKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIA 479

  Fly   636 TGMIFWSDVTTQSIYKAPIDEGNEKTVVLTKSSVTSDGLAVDWIYNHVYFTDTHKCTIELTNFEG 700
            ...:||:|::.::|:.|.||:...:.|.:..:......:||||:|..:|:||....||.:...:|
Human   480 AQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDG 544

  Fly   701 SMGKVLVKDSLDIPRSIALDPIEGWMYWSDWGASPRIERAGMDGSHRTTIISYDVKWPNGITLDL 765
            :..|.|....|..|.|||:||:.|::||||||...:||:|||:|..|..:::.|::|||||||||
Human   545 TKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDL 609

  Fly   766 VKKRIYWVDGKLNVISSANYDGSQRSQVLYSGEYLRHPFSITTFEDNVYWTDWDKQAVFKANKFT 830
            :|.|:||:|.||:::||.:.:|..|..||.|.|:|.||.::|.|||.|||.|.:.:||:.|||||
Human   610 IKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFT 674

  Fly   831 GEDVEPVTAMHMLQHPMVVHVYHPYRQPDGVNHCQS--VNGHCSHLCLPAPRINERSPRISCACP 893
            |.::  .|.::.|.....:.|||...||.|.|.|:.  .||.|.:||||||:||:.||:.:|:||
Human   675 GSEL--ATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCP 737

  Fly   894 TGLKLMVDGLMCVEDPLYLPPVTRPPRARKTKPRPKSPRRRLPTGVQVGHADIRIEINDDLQLST 958
            :|..:..:|..|..                             |...|.:::.:  ..:..::|.
Human   738 SGYNVEENGRDCQS-----------------------------TATTVTYSETK--DTNTTEISA 771

  Fly   959 RLPLLPTTFVADQRPVKNHTQIEKTTTPSEQPDSGF----IALVVIASLSGFAVLLSVLLLIGYR 1019
            ...|:|       ..:...|.:.:.:.|.:...:.:    :.|:|:|::.|:.:         :|
Human   772 TSGLVP-------GGINVTTAVSEVSVPPKGTSAAWAILPLLLLVMAAVGGYLM---------WR 820

  Fly  1020 YCSKRRINSMNFENPIYRKTTTTEDHFSLRKNLPARIYDHTSVMDEEYSPVIGISS 1075
            ....:.:.||||:||:|.|||        .::|...|..|::.:...| |.|.:.|
Human   821 NWQHKNMKSMNFDNPVYLKTT--------EEDLSIDIGRHSASVGHTY-PAISVVS 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LpR1	NP_001097934.2	LDLa	135..167	CDD:197566	17/31 (55%)
		LDLa	178..210	CDD:197566	16/31 (52%)
		LDLa	219..254	CDD:238060	0/34 (0%)
		LDLa	259..295	CDD:238060	14/35 (40%)
		LDLa	343..373	CDD:238060	16/31 (52%)
		LDLa	383..415	CDD:197566	15/31 (48%)
		Ldl_recept_a	423..459	CDD:278486	22/35 (63%)
		LDLa	476..504	CDD:197566	11/27 (41%)
		FXa_inhibition	514..549	CDD:291342	15/34 (44%)
		EGF_CA	551..581	CDD:214542	19/29 (66%)
		LY	662..702	CDD:214531	12/39 (31%)
		LY	704..747	CDD:214531	22/42 (52%)
		LY	749..790	CDD:214531	20/40 (50%)
		FXa_inhibition	864..905	CDD:291342	19/42 (45%)
VLDLR	NP_003374.3	LDLa	33..67	CDD:238060	19/35 (54%)
		LDLa	71..103	CDD:197566	16/31 (52%)
		Ldl_recept_a	111..149	CDD:278486	16/37 (43%)
		LDLa	154..188	CDD:238060	19/33 (58%)
		Ldl_recept_a	192..224	CDD:278486	15/32 (47%)
		Ldl_recept_a	237..273	CDD:278486	18/38 (47%)
		Ldl_recept_a	276..312	CDD:278486	22/35 (63%)
		Ldl_recept_a	320..350	CDD:278486	11/29 (38%)
		FXa_inhibition	360..394	CDD:291342	15/34 (44%)
		EGF_CA	396..426	CDD:214542	19/29 (66%)
		Ldl_recept_b	481..521	CDD:278487	9/39 (23%)
		LY	505..547	CDD:214531	12/41 (29%)
		Ldl_recept_b	568..608	CDD:278487	21/39 (54%)
		LY	592..634	CDD:214531	20/41 (49%)
		Ldl_recept_b	655..694	CDD:278487	15/40 (38%)
		FXa_inhibition	706..749	CDD:291342	19/42 (45%)
		Mucin	<751..813	CDD:250634	10/99 (10%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	55	1.000	Domainoid score	I11132
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H443
Inparanoid	1	1.050	713	1.000	Inparanoid score	I644
Isobase	1	0.950	-	0	Normalized mean entropy	S4504
OMA	1	1.010	-	-		QHG49125
OrthoDB	1	1.010	-	-		D179614at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8553
orthoMCL	1	0.900	-	-		OOG6_103130
Panther	1	1.100	-	-	O	PTHR24270
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7933
SonicParanoid	1	1.000	-	-		X1052
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.960