DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LpR1 and vldlr

DIOPT Version :9

Sequence 1:	NP_001097934.2	Gene:	LpR1 / 2768687	FlyBaseID:	FBgn0066101	Length:	1076	Species:	Drosophila melanogaster
Sequence 2:	XP_002934223.1	Gene:	vldlr / 733485	XenbaseID:	XB-GENE-971958	Length:	868	Species:	Xenopus tropicalis

Alignment Length:	978	Identity:	374/978 - (38%)
Similarity:	509/978 - (52%)	Gaps:	168/978 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 LGIGQSLEAKCDEKQFQCHSGDCIPIRFVCDGDADCKDHSDEQIKECKFIEATCSSDQFRCGNGN 190
            ||:..:.:..|:..||||.:|.||...:.||||.||.|.|||  ..|  ::.||:...|.|.||.
Frog    21 LGLVHATKTLCEGSQFQCANGHCITSLWKCDGDEDCSDGSDE--SSC--VKKTCAETDFVCNNGL 81

  Fly   191 CIPNKWRCDQESDCADGSDEANELC-MNACPNNEFKC-QTVDQCIPRSWLCDGSNDCRDKSDEAH 253
            |:|.:|.||.:.||.|||||..||| |..|...|..| ....||||.||.|||.:||.:..||.:
Frog    82 CVPRRWECDGDPDCEDGSDETAELCHMRTCRATEISCGARSTQCIPLSWKCDGESDCPNAEDEEN 146

  Fly   254 CRARTCSPDEYACKSGEGQCVPLAWMCDQSKDCSDGSDEHNC-NQTCRADEFTCGNGRCIQKRWK 317
            |...||||.|:.|.|  |:|:...::|:...||||||||.|| ..||.|.||.|.|..||...|.
Frog   147 CGNITCSPAEFTCSS--GRCISSTFVCNGQNDCSDGSDEENCVPPTCGAHEFQCKNSSCIPLNWV 209

  Fly   318 CDHDDDCGDGSDE--KEC---PVVP--CDSVAEHTCTNGACIAKRWVCDGDPDCSDGSDERSCAN 375
            ||.|.||.|.|||  ::|   |:.|  | |..|..|.:|.||.|:|.|||||||.|.|||
Frog   210 CDDDSDCADHSDESLEQCGRQPIAPQKC-SANEMPCGSGECIHKKWRCDGDPDCKDKSDE----- 268

  Fly   376 VTKTTTPCLSHEYQCKDRITCLHHSWLCDGDRDCPDGDDEHTANCKNVTCRADQFQCGDRSCIPG 440
                                                      .||.:.||:.|||:|.|.:||.|
Frog   269 ------------------------------------------MNCPSRTCQPDQFKCEDGNCIHG 291

  Fly   441 HLTCNGDKDCADGSDERDCGLSLSLGINQGGCNATSEFDCGGGQCVPLSKVCDKRKDCPDGEDEP 505
            ...|:|.:||.||:||..|     ..:||  |:...:|.|..|:|:.::|||:|:|||.|..|||
Frog   292 SRQCDGVRDCLDGTDEIRC-----KNVNQ--CSGPGKFKCRSGECIDIAKVCNKQKDCKDWSDEP 349

  Fly   506 AGKCGINECASKNGGCMHQCIDLKVGHHCECHEGYKLSPDKRNCQDINECEVPGKCSQICVNEIG 570
            ..:|.:|||...||||.|.|.:|.:|:.|:|..|:||. |::.|.||:||:.|..|||||||..|
Frog   350 IKECYVNECEVNNGGCSHLCHNLVIGYECDCTAGFKLI-DRKTCGDIDECQNPEICSQICVNLKG 413

  Fly   571 GFKCECEAGYMRDPKNHTRCKASEGHASLLLARRHDIRKIALDHMEMTSIVNSTKAATALDFVFR 635
            |:||||..||..||.... |||......|:...|.||||:.|:..|...:|...:...|||...:
Frog   414 GYKCECSKGYQMDPSTGV-CKAVGREPCLIFTNRRDIRKVGLERKEYIQLVEQLRNTVALDADIK 477

  Fly   636 TGMIFWSDVTTQSIYKAPIDEGNEKTVVLTKSSVTSD-----GLAVDWIYNHVYFTDTHKCTIEL 695
            ...:||:|...::|::||.|. .||  |.|...|..|     .:|:||||.::|:.||...||.:
Frog   478 EQSLFWADTIQKAIFRAPFDT-REK--VGTHIKVVEDVHSPSAIAIDWIYKNIYWMDTGLKTISV 539

  Fly   696 TNFEGSMGKVLVKDSLDIPRSIALDPIEGWMYWSDWGASPRIERAGMDGSHRTTIISYDVKWPNG 760
            :||:||..|.|....|..|.|||:|||.|::||||||...:||:|||:|..|...::.||:.|:|
Frog   540 SNFDGSKRKTLFNSGLQDPTSIAVDPISGFIYWSDWGEPAKIEKAGMNGIDRQQFVTADVQRPSG 604

  Fly   761 ITLDLVKKRIYWVDGKLNVISSANYDGSQRSQVLYSGEYLRHPFSITTFEDNVYWTDWDKQAVFK 825
            |.:|:||.|:||||.||:.:||.:.:|..|..:|.|.|:|.||.::|.|||.|||.|.:.:|::.
Frog   605 IAIDVVKSRLYWVDSKLHTLSSVDLNGLDRRVILKSHEFLAHPLALTIFEDRVYWIDGENEAIYG 669

  Fly   826 ANKFTGEDVEPVTAMHMLQHPMVVHVYHPYRQPDGVNHC--QSVNGHCSHLCLPAPRINERSPRI 888
            ||||:|:::|  |.::.|.....|.|||...||.|.|.|  |..||.|.:||||||:|::.||:.
Frog   670 ANKFSGQELE--TLVNNLNEAQDVIVYHELVQPLGRNWCNEQIENGGCKYLCLPAPQISDNSPKY 732

  Fly   889 SCACPTGLKLMVDGLMCVEDPLYLPPVTRPPRARKTKPRPKSPRRRLPTGVQVGHADIRIEIND- 952
            :|.||.|.:|. .|..|       .|.::.......||....|::.||:|           .||
Frog   733 TCVCPDGFELN-GGRSC-------RPGSKATMDHTVKPTGILPKKPLPSG-----------DNDT 778

  Fly   953 ----DLQLSTR--------LPLLPTTFVADQRPVKNHTQIEKTTTPSEQPDSGFIALVVIASLSG 1005
                ::.||.:        ||||                                 |:.:|:..|
Frog   779 NSIHEVNLSAKGTSAAWAILPLL---------------------------------LIAMAASGG 810

  Fly  1006 FAVLLSVLLLIGYRYCSKRRINSMNFENPIYRKTTTTEDHFSLRKNLPARIYDHTSVMDEEYSPV 1070
            :.:         :|...::.:.||||:||:|.|||        .::|...|..|...:...| |.
Frog   811 YLM---------WRNWQQKNMKSMNFDNPVYLKTT--------EEDLAIDIGRHGGNIGHTY-PA 857

  Fly  1071 IGI 1073
            |.:
Frog   858 ISV 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LpR1	NP_001097934.2	LDLa	135..167	CDD:197566	16/31 (52%)
		LDLa	178..210	CDD:197566	16/31 (52%)
		LDLa	219..254	CDD:238060	16/35 (46%)
		LDLa	259..295	CDD:238060	17/35 (49%)
		LDLa	343..373	CDD:238060	18/29 (62%)
		LDLa	383..415	CDD:197566	0/31 (0%)
		Ldl_recept_a	423..459	CDD:278486	18/35 (51%)
		LDLa	476..504	CDD:197566	12/27 (44%)
		FXa_inhibition	514..549	CDD:291342	15/34 (44%)
		EGF_CA	551..581	CDD:214542	19/29 (66%)
		LY	662..702	CDD:214531	17/44 (39%)
		LY	704..747	CDD:214531	23/42 (55%)
		LY	749..790	CDD:214531	18/40 (45%)
		FXa_inhibition	864..905	CDD:291342	20/42 (48%)
vldlr	XP_002934223.1	LDLa	31..65	CDD:238060	18/35 (51%)
		Ldl_recept_a	68..101	CDD:365841	16/32 (50%)
		Ldl_recept_a	109..147	CDD:365841	16/37 (43%)
		Ldl_recept_a	151..186	CDD:365841	18/36 (50%)
		LDLa	190..222	CDD:197566	17/31 (55%)
		Ldl_recept_a	236..271	CDD:365841	20/82 (24%)
		Ldl_recept_a	274..310	CDD:365841	18/35 (51%)
		LDLa	316..348	CDD:197566	13/31 (42%)
		FXa_inhibition	358..392	CDD:373209	15/34 (44%)
		EGF_CA	394..424	CDD:214542	19/29 (66%)
		LY	505..547	CDD:214531	16/41 (39%)
		LY	548..591	CDD:214531	23/42 (55%)
		LY	592..634	CDD:214531	18/41 (44%)
		Ldl_recept_b	655..694	CDD:393440	15/40 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	58	1.000	Domainoid score	I10588
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H443
Inparanoid	1	1.050	700	1.000	Inparanoid score	I657
OMA	1	1.010	-	-		QHG49125
OrthoDB	1	1.010	-	-		D179614at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9446
Panther	1	1.100	-	-	O	PTHR24270
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7933
SonicParanoid	1	1.000	-	-		X1052
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110