DRSC/TRiP Functional Genomics Resources

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Protein Alignment LpR1 and lrp1ab

DIOPT Version :10

Sequence 1:NP_001097934.2 Gene:LpR1 / 2768687 FlyBaseID:FBgn0066101 Length:1076 Species:Drosophila melanogaster
Sequence 2:XP_021325646.1 Gene:lrp1ab / 565797 ZFINID:ZDB-GENE-030131-7126 Length:4562 Species:Danio rerio


Alignment Length:833 Identity:324/833 - (38%)
Similarity:450/833 - (54%) Gaps:90/833 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly   140 QFQCHSGDCIPIRFVCDGDADCKDHSDEQ---------------------IKECKFIEAT----- 178
            :|:|.:||||.....||..|.|||.|||:                     ||...:.::|     
Zfish  2530 EFECGNGDCIDYSLTCDSLAHCKDKSDEKQAYCANRMCKKGYRRCINGRCIKHSSWCDSTDDCGD 2594

  Fly   179 -----------CSSDQFRCGNGNCIPNKWRCDQESDCADGSDEANELCMNACPNN---------- 222
                       ||:.:|:|.:|:||.|..||:|..||.|.|||     ||..|.:          
Zfish  2595 GSDELPCNMTLCSAAEFQCKDGSCITNSSRCNQVVDCEDASDE-----MNCSPTDCSSYYLLGVK 2654

  Fly   223 --EF-KCQTVDQCIPRSWLCDGSNDCRDKSDEAHC---RARTCSPDEYACKSGEGQCVPLAWMCD 281
              .| :|:....|...||.|||||||.|.|||.:|   |.:.||.:.:||.|  |:|:|::|.||
Zfish  2655 GMTFERCEFTTLCFAPSWRCDGSNDCGDFSDERNCPEKRQQKCSENNFACPS--GRCIPMSWTCD 2717

  Fly   282 QSKDCSDGSDEHNCN---QTCRADEFTCGNGRCIQKRWKCDHDDDCGDGSDE-KECPVVPCDSVA 342
            :..||.||:||.:|.   |.|.:::|.|||.|||.|.|.||..||||||:|| ..|....|...:
Zfish  2718 KENDCEDGADEAHCEKFFQFCASNQFECGNHRCIFKTWVCDGTDDCGDGTDEDSRCKAKTCGPDS 2782

  Fly   343 EHTCTNGACIAKRWVCDGDPDCSDGSDERSCANVTKTTTPCLSHEYQCKDRITCLHHSWLCDGDR 407
            .....:..||.:|||||||.||.||.||...|......| |...|:||::. .|:..:::||.|.
Zfish  2783 FQCPGSHVCILQRWVCDGDKDCPDGGDEGLKAGCVFNKT-CDDTEFQCQNS-QCIPKNFMCDHDI 2845

  Fly   408 DCPDGDDEHTANCKNVTCRADQFQCGDRSCI-PGHLTCNGDKDCADGSDERDCGLSLSLGINQGG 471
            ||.||.|| :..|:..||..:.|.|.:..|: ..:..|:|:.||.|.|||....|..:  ..:..
Zfish  2846 DCRDGSDE-SPECEYPTCGPNDFHCANGQCLKQKNWACDGEFDCRDQSDEAPKNLQCT--DTESR 2907

  Fly   472 CNATSEFDCGGGQCVPLSKVCDKRKDCPDGEDEPAGKCGINECA-SKNGGCMHQCIDLKVGHHCE 535
            ||.|: |.|..|:||..:.:||...||.||.||  ..|.:|||. ||..||...|.|||:|..|.
Zfish  2908 CNDTA-FLCSSGKCVNETLLCDNNNDCGDGSDE--NNCFVNECLNSKLSGCSQLCEDLKIGFKCR 2969

  Fly   536 CHEGYKLSPDKRNCQDINECEVPGKCSQICVNEIGGFKCECEAGYMRDPKNHTRCKA-SEGHASL 599
            |:.|::|..|.:.|.|::||.....|||.|:|..|.|.|.|..|::..|.:||.||: :|....|
Zfish  2970 CNAGFRLKQDGKTCVDLDECSTVYPCSQRCINTHGSFHCLCVDGFVPRPDDHTSCKSTAEEEPFL 3034

  Fly   600 LLARRHDIRKIALDHMEMTSIVNSTKAATALDFVFRTGMIFWSDVTTQS--IYKAPIDEGNEKTV 662
            :.|.|:.:||:.||....|.|......|.|||:.:...||:|:|||||.  |.:..|:..|.:  
Zfish  3035 IFANRYYLRKLNLDGSNYTLIKQGLNNAVALDYHYAEQMIYWTDVTTQGSMIRRMHINGSNVQ-- 3097

  Fly   663 VLTKSSVTS-DGLAVDWIYNHVYFTDTHKCTIELTNFEGSMGKVLVKDSLDIPRSIALDPIEGWM 726
            ||.::|::: |||||||:..::|:.|..:.|||::...|:...|||...|..||::|:|...|::
Zfish  3098 VLHRTSLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRSVLVNSGLREPRAVAVDVRNGYL 3162

  Fly   727 YWSDWGASPRIERAGMDGSHRTTIISYDVKWPNGITLDLVKKRIYWVDGKLNVISSANYDGSQRS 791
            ||||||..|.|.|.||||:.|..||...:.||||:|||.:..||||.|.:.:.|:.|:.|||.|.
Zfish  3163 YWSDWGDVPHIGRIGMDGTDRQIIIQDKITWPNGLTLDFINDRIYWADAREDYIAFASLDGSNRH 3227

  Fly   792 QVLYSGEYLRHPFSITTFEDNVYWTDWDKQAVFKANKFTGEDVEPVTAMHMLQHPMVVHVYHPYR 856
            .||  ...:.|.|::|.||:.:|||||:.:::.:|:|..|  ......:..|..||.:|::||.|
Zfish  3228 TVL--NHDIPHIFAMTLFEEFIYWTDWETKSINRAHKTLG--TNKTLLISTLHRPMDIHIFHPSR 3288

  Fly   857 QPDGVNH-CQSVNGHCSHLCLPAPRINERSPRISCACPTGLKLMVDGLMCVED 908
            ||:...| ||..||.||:|||.:|     .....|||||...|..||..|:.:
Zfish  3289 QPEVSGHPCQEDNGGCSNLCLLSP-----GGGYKCACPTNFYLAADGKQCLSN 3336

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LpR1NP_001097934.2 LDLa 135..167 CDD:197566 13/26 (50%)
LDLa 178..210 CDD:197566 16/47 (34%)
LDLa 219..254 CDD:238060 17/47 (36%)
LDLa 259..295 CDD:238060 17/35 (49%)
LDLa 343..373 CDD:238060 15/29 (52%)
LDLa 383..415 CDD:197566 12/31 (39%)
Ldl_recept_a 423..459 CDD:395011 13/36 (36%)
LDLa 476..504 CDD:197566 11/27 (41%)
FXa_inhibition 514..549 CDD:464251 15/35 (43%)
EGF_CA 551..581 CDD:214542 13/29 (45%)
LY 662..702 CDD:214531 16/40 (40%)
LY 704..747 CDD:214531 22/42 (52%)
LY 749..790 CDD:214531 19/40 (48%)
Ldl_recept_b 769..815 CDD:459654 18/45 (40%)
FXa_inhibition 864..905 CDD:464251 18/40 (45%)
lrp1abXP_021325646.1 LDLa 36..69 CDD:197566
LDLa 81..114 CDD:197566
FXa_inhibition 168..198 CDD:464251
NHL <292..479 CDD:302697
NHL repeat 292..325 CDD:271320
LY 323..365 CDD:214531
NHL repeat 332..368 CDD:271320
LY 368..408 CDD:214531
NHL repeat 373..413 CDD:271320
NHL repeat 421..467 CDD:271320
FXa_inhibition 493..526 CDD:464251
LY 558..600 CDD:214531
LY 602..640 CDD:214531
LY 647..695 CDD:214531
LY <707..740 CDD:214531
FXa_inhibition 811..846 CDD:464251
LDLa 857..889 CDD:197566
LDLa 899..932 CDD:238060
LDLa 940..971 CDD:238060
LDLa 982..1015 CDD:238060
LDLa 1019..1052 CDD:238060
LDLa 1066..1101 CDD:238060
LDLa 1110..1144 CDD:238060
LDLa 1149..1185 CDD:238060
FXa_inhibition 1188..1224 CDD:464251
Vgb 1277..1506 CDD:443399
LY 1339..1381 CDD:214531
Ldl_recept_b 1631..1670 CDD:459654
LY 1653..1696 CDD:214531
LY 1700..1739 CDD:214531
LY 1739..1780 CDD:214531
FXa_inhibition 1853..1889 CDD:464251
LY 1919..1959 CDD:214531
LY 1962..2002 CDD:214531
Ldl_recept_b 2023..2064 CDD:459654
LY 2048..2090 CDD:214531
FXa_inhibition 2162..2197 CDD:464251
SGL 2288..>2429 CDD:462480
Ldl_recept_b 2346..2388 CDD:459654
LY 2372..2413 CDD:214531
FXa_inhibition 2483..2518 CDD:464251
LDLa 2523..2559 CDD:412164 15/28 (54%)
LDLa 2567..2601 CDD:238060 3/33 (9%)
LDLa 2606..2640 CDD:238060 18/38 (47%)
LDLa <2667..2689 CDD:238060 14/21 (67%)
LDLa 2697..2731 CDD:238060 17/35 (49%)
LDLa 2738..2769 CDD:197566 18/30 (60%)
LDLa 2777..2810 CDD:197566 14/32 (44%)
LDLa 2821..2853 CDD:197566 13/33 (39%)
Ldl_recept_a 2861..2895 CDD:395011 12/33 (36%)
LDLa 2908..2942 CDD:238060 16/36 (44%)
FXa_inhibition 2954..2983 CDD:464251 12/28 (43%)
EGF_CA 2985..3019 CDD:214542 13/33 (39%)
LY 3052..3096 CDD:214531 16/43 (37%)
LY 3097..3139 CDD:214531 16/43 (37%)
LY 3141..3183 CDD:214531 22/41 (54%)
LY 3184..3226 CDD:214531 19/41 (46%)
LY 3227..3267 CDD:214531 15/43 (35%)
FXa_inhibition 3297..3333 CDD:464251 18/40 (45%)
LDLa 3337..3368 CDD:238060 324/833 (39%)
LDLa 3377..3411 CDD:238060
LDLa 3416..3451 CDD:238060
LDLa 3455..3488 CDD:197566
LDLa 3496..3529 CDD:197566
LDLa 3539..3573 CDD:238060
LDLa 3578..3612 CDD:238060
LDLa 3616..3650 CDD:238060
LDLa 3658..3690 CDD:238060
LDLa 3699..3735 CDD:238060
LDLa 3741..3776 CDD:238060
EGF_CA 3825..3855 CDD:214542
LY 3963..3999 CDD:214531
Ldl_recept_b 4020..4061 CDD:459654
LY 4044..4085 CDD:214531
Blue background indicates that the domain is not in the aligned region.

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