DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LpR1 and lrp13

DIOPT Version :9

Sequence 1:	NP_001097934.2	Gene:	LpR1 / 2768687	FlyBaseID:	FBgn0066101	Length:	1076	Species:	Drosophila melanogaster
Sequence 2:	XP_021327248.1	Gene:	lrp13 / 562438	ZFINID:	ZDB-GENE-130729-1	Length:	1354	Species:	Danio rerio

Alignment Length:	895	Identity:	304/895 - (33%)
Similarity:	435/895 - (48%)	Gaps:	118/895 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 CDEKQFQC-HSGDCIPIRFVCDGDADCKDHSDEQIKECKFIEATCSSDQFRC-GNGNCIPNKWRC 198
            |....||| |...||.:|.||||...|:|.|||  ..|...:..|:   .|| ||..|:|..:.|
Zfish    75 CSVGHFQCAHGKMCIWLRQVCDGVPQCQDRSDE--LNCFKPDDGCA---HRCDGNTRCVPESFVC 134

  Fly   199 DQESDCADGSDEAN-------------------------ELCMNA--------CPNNEFKCQTVD 230
            |.:.||.|||||||                         |:..|.        |......|:...
Zfish   135 DGDVDCVDGSDEANCENPDDDDDDDEDLLDEKEEMTGEHEVSQNVPATKGPLRCSIASKLCRDGT 199

  Fly   231 QCIPRSWLCDGSNDCRDKSDEAHCRARTCSPDEYACKSGEGQCVPLAWMCDQSKDCSDGSDEHNC 295
            .|:..:.:|||..||:|.|||..|..: |...::.|..|: :|:....:||....|.|.|||.||
Zfish   200 DCVMLNHVCDGELDCKDGSDEEDCPVQ-CESGQFQCAHGK-KCIDRRQLCDGVPQCQDRSDELNC 262

  Fly   296 ---NQTC--RADEFTCGNGRCIQKRWKCDHDDDCGDGSDEKECPVVPCDSVAEHTCTNGACIAKR 355
               :..|  |.||    |.||:.:.:.||.|.||.|||||..|....|.| ||..|::|.|::..
Zfish   263 FKPDDDCAHRCDE----NTRCVPESFVCDGDPDCVDGSDEANCGEESCSS-AEWQCSSGQCVSLS 322

  Fly   356 WVCDGDPDCSDGSDERSCANVTKTTTPCLSHEYQCKDRITCLHHSWLCDGDRDCPDGDDEHTANC 420
            ..|||..||.|.|||..||.    ..|| |...:|.....||...|:|||:.||.||.||  .||
Zfish   323 MRCDGHSDCRDHSDEEDCAE----PPPC-STNRRCPKSHECLLDEWMCDGETDCKDGTDE--KNC 380

  Fly   421 KN--VTCRADQFQCGDRS-CIPGHLTCNGDKDCADGSDERDCGLSLSLGINQGGCNATSEFDCGG 482
            |.  |.|...||.|..:: |||....|:|.:||.|||||..|. |:|       | ....|.||.
Zfish   381 KESPVQCGEYQFSCSSKTQCIPQSWRCDGSEDCRDGSDESACA-SVS-------C-PPHLFQCGS 436

  Fly   483 GQCVPLSKVCDKRKDCPDGEDEPAGKCGINECASKNGGCMHQCIDLKVGHHCECHEGYKLSPDKR 547
            .:||..|::|:...:|.||.|| .|.|...:| |:...|...|.....|..|.|..|||...|..
Zfish   437 SECVEFSQLCNGVTNCLDGSDE-GGSCQTEKC-SEQLKCAQDCHSTPAGARCGCRMGYKPVDDGL 499

  Fly   548 NCQDINEC-EVPGKCSQICVNEIGGFKCECEAGYMRDPKNHTRCKASEGHASLLLARRHDIRKIA 611
            .|.|::|| |.|..||..|.|.:|.|:|.|..||:.:|..|: ||.: |...||.:.:.::..:.
Zfish   500 RCADVDECVERPNICSHRCNNTLGSFQCSCSHGYVLEPDGHS-CKIT-GEPYLLASVQSEVFLLG 562

  Fly   612 LDHMEMTSIVNSTKA-ATALDFVFRTGMIFWSDVTTQSIYKAPIDEGNEKTVVLTKSSVTSDGLA 675
            |....:..::::.|. ..:||:.::...::|.::.|.:|....:|:.|:.|.:   ..:::|.||
Zfish   563 LRSSSLDILLSAEKRFVLSLDYDWQKQRVYWINLNTDTIKWLSLDQKNKGTFL---KGISADSLA 624

  Fly   676 VDWIYNHVYFTDTHKCTIELTNFEGSMGK-----VLVKDSLDIPRSIALDPIEGWMYWSDWGASP 735
            |||:..::|:||:....|.....:..:|:     :::.:.|...|||||.|.:|.|:||:.|...
Zfish   625 VDWVARNLYWTDSENSQINAVRLDSEIGRSTDRVMILGEDLGQLRSIALMPQKGIMFWSETGDEA 689

  Fly   736 RIERAGMDGSHRTTIISYDVKWPNGITLDLVKKRIYWVDGKLNVISSANYDGS--QRSQVLYSGE 798
            :|||||||||.|..::|..::||..:|:|.:.:||||.|.||..|.|||.||.  :..|::.:..
Zfish   690 QIERAGMDGSDRRVLVSKSLRWPVSLTVDSLHQRIYWTDEKLKCIGSANIDGGDVKLLQLMETPS 754

  Fly   799 YLRHPFSITTFEDNVYWTDWDKQAVFKANKFTGEDVEPVTAMHMLQHPMVVHVYHPYRQPDGVNH 863
                |||::.|.|.|||:|..:..:.:|:|.||:..:  ..:.....|..:.|.|...|.|..|.
Zfish   755 ----PFSVSVFNDQVYWSDTKRGTIQRAHKTTGKQRQ--VLLKRPGQPFGLKVIHGLLQEDVSNP 813

  Fly   864 CQSVNGHCSHLCLPAPRINERSPRISCACPTGLKLMVDGLMCVEDP-----LYLPP--VTR---P 918
            |:|..  |||||:.||.:     :..|.|.|...|..|||.|.:..     |:|.|  ||:   .
Zfish   814 CESQG--CSHLCVLAPGL-----KAVCKCSTQFLLDEDGLTCSKPKDSSFLLFLSPAAVTQVYLQ 871

  Fly   919 PRARKTKPR--PKSPRRRLPTGVQVGHADIRIEINDDLQL---STRLPLL 963
            .|.....|:  |:..|..||   ::.|.::...:..||.|   .|..||:
Zfish   872 NRHSDVTPQKWPEHRRFDLP---KMNHPNMLDLVLRDLTLYVSDTDQPLV 918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LpR1	NP_001097934.2	LDLa	135..167	CDD:197566	15/31 (48%)
		LDLa	178..210	CDD:197566	14/32 (44%)
		LDLa	219..254	CDD:238060	12/34 (35%)
		LDLa	259..295	CDD:238060	11/35 (31%)
		LDLa	343..373	CDD:238060	13/29 (45%)
		LDLa	383..415	CDD:197566	13/31 (42%)
		Ldl_recept_a	423..459	CDD:278486	17/36 (47%)
		LDLa	476..504	CDD:197566	10/27 (37%)
		FXa_inhibition	514..549	CDD:291342	11/34 (32%)
		EGF_CA	551..581	CDD:214542	14/30 (47%)
		LY	662..702	CDD:214531	10/39 (26%)
		LY	704..747	CDD:214531	21/47 (45%)
		LY	749..790	CDD:214531	18/42 (43%)
		FXa_inhibition	864..905	CDD:291342	16/40 (40%)
lrp13	XP_021327248.1	LDLa	36..71	CDD:238060
		LDLa	75..110	CDD:238060	17/36 (47%)
		LDLa	119..149	CDD:238060	16/29 (55%)
		LDLa	195..223	CDD:238060	11/27 (41%)
		LDLa	227..262	CDD:238060	11/35 (31%)
		LDLa	271..301	CDD:238060	16/33 (48%)
		LDLa	306..340	CDD:238060	16/34 (47%)
		LDLa	351..380	CDD:238060	13/30 (43%)
		LDLa	387..422	CDD:238060	16/34 (47%)
		LDLa	427..458	CDD:197566	11/31 (35%)
		EGF_CA	503..542	CDD:311536	17/39 (44%)
		PHA02142	<569..>666	CDD:333147	20/99 (20%)
		LY	<622..648	CDD:214531	9/25 (36%)
		Ldl_recept_b	680..718	CDD:278487	18/37 (49%)
		LY	702..744	CDD:214531	18/41 (44%)
		LY	744..786	CDD:214531	14/45 (31%)
		FXa_inhibition	818..848	CDD:317114	14/36 (39%)
		LY	976..1021	CDD:214531
		FXa_inhibition	1130..1162	CDD:317114
		LDLa	1170..1202	CDD:197566
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910