DRSC/TRiP Functional Genomics Resources

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Protein Alignment LpR1 and lrp8

DIOPT Version :10

Sequence 1:NP_001097934.2 Gene:LpR1 / 2768687 FlyBaseID:FBgn0066101 Length:1076 Species:Drosophila melanogaster
Sequence 2:XP_073809120.1 Gene:lrp8 / 557734 ZFINID:ZDB-GENE-050506-134 Length:1008 Species:Danio rerio


Alignment Length:978 Identity:378/978 - (38%)
Similarity:509/978 - (52%) Gaps:114/978 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   179 CSSDQFRCGNGNCIPNKWRCDQESDCADGSDEANELC-MNACPNNEFKCQTVDQCIPRSWLCDGS 242
            |.|.||:|.||.|||..||||.:.||:|.|||.|  | ...|...:|.|:. .||:|..|.|||.
Zfish    28 CESGQFQCRNGRCIPTPWRCDDDDDCSDNSDEEN--CPKKTCATTDFACKN-GQCVPGRWRCDGE 89

  Fly   243 NDCRDKSDEAH--CRARTCSPDEYACKSGEGQCVPLAWMCDQSKDCSDGSDEHNC---NQTCRAD 302
            .:|.|.||||.  |..:||.|:::.|.....:||.|:|.||..:||.:|:||..|   .:.|.|.
Zfish    90 PECPDGSDEADSACSRQTCPPEKFDCGGSTSKCVSLSWRCDGERDCENGADEEQCAADAKACPAK 154

  Fly   303 EFTCGNGRCIQKRWKCDHDDDCGDGSDEKECPVVPCDSVAEH--TCTNGACIAKRWVCDGDPDCS 365
            ||.|.|..|:...:.||.||||||.|||::|......:...|  .|.:..||...|.|||||||.
Zfish   155 EFQCRNRMCVAPTFVCDGDDDCGDRSDEEKCTAATASTCGPHEFRCNDSECIPTPWSCDGDPDCR 219

  Fly   366 DGSDE--RSCANVTKTTTP-CLSHEYQCKDRITCLHHSWLCDGDRDCPDGDDEHTANCKNVTCRA 427
            |.|||  ..|:..|:...| |...|::|:.. .|:|.:|.||||.||.|..||  |||..:|||.
Zfish   220 DKSDESLERCSRRTEPQKPHCSMGEFRCRSG-ECIHLNWKCDGDPDCKDKSDE--ANCPVLTCRP 281

  Fly   428 DQFQCGDRSCIPGHLTCNGDKDCADGSDERDCGLSLSLGINQ-GGCNATSEFDCGGGQCVPLSKV 491
            |||||||.|||.|...||...||.|.|||..|       :|: ..|....:|.|..|:|:..|||
Zfish   282 DQFQCGDGSCIHGTKQCNKVHDCPDFSDEAGC-------VNRTNKCEGPLKFMCKSGECIDSSKV 339

  Fly   492 CDKRKDCPDGEDEPAGKCGINECASKNGGCMHQCIDLKVGHHCECHEGYKLSPDKRNCQDINECE 556
            ||..:||.|..|||..:||:||||..||||.|.|.|.::|..|:|..||||. ||:.|.||:|||
Zfish   340 CDTIRDCKDWSDEPVKECGLNECAINNGGCSHICKDRQIGFECQCPSGYKLL-DKKTCGDIDECE 403

  Fly   557 VPGKCSQICVNEIGGFKCECEAGYMRDPKNHTRCKASEGHASLLLARRHDIRKIALDHMEMTSIV 621
            .|..|||||:|..|.:||||..||..||...| |||......|:...||:||:|.|...:.|.:|
Zfish   404 NPEACSQICINLKGDYKCECYEGYEMDPVTKT-CKAVGKSPYLMFTNRHEIRRIDLLKKDYTQVV 467

  Fly   622 NSTKAATALDFVFRTGMIFWSDVTTQSIYKAPIDEGN---EKTVVLTKSSVTSDGLAVDWIYNHV 683
            .:.|.|.|||....|..::|.|:..:.|:.|.|::.|   |:..::..:..:.:|||:||::.::
Zfish   468 PTLKNAVALDVDVTTNKMYWCDLYHRKIFSAYINKANNSSEQITLIDTALHSPEGLAMDWVHKNI 532

  Fly   684 YFTDTHKCTIELTNFEGSMGKVLVKDSLDIPRSIALDPIEGWMYWSDWGASPRIERAGMDGSHRT 748
            |:||:...||.:.|.:|...|||:...|..||:||:||.:|:||||||||..:||:|||:|..|.
Zfish   533 YWTDSGHKTISVANVDGKKRKVLIDTELGEPRAIAVDPRQGFMYWSDWGAQAKIEKAGMNGVDRQ 597

  Fly   749 TIISYDVKWPNGITLDLVKKRIYWVDGKLNVISSANYDGSQRSQVLYSGEYLRHPFSITTFEDNV 813
            .::|..::|||||.|||...|:||||.||::|||.:.:|..|..:|.|.:.|.|||::|.|||.|
Zfish   598 VLVSERIEWPNGIALDLSSSRLYWVDSKLHLISSVDLNGDNRRILLSSMDQLGHPFALTLFEDRV 662

  Fly   814 YWTDWDKQAVFKANKFTGEDVEPVTAMHMLQHPMVVHVYHPYRQ---PDGVNHCQSVNGHCSHLC 875
            ||||.:.:|::..|:.||.|| .:.|.| |.:|:.|.|:|..||   ||..|.....||.|.:||
Zfish   663 YWTDLEYEAIYSVNRLTGNDV-VMLAQH-LNNPLDVVVFHELRQPKVPDTCNMGNLPNGGCEYLC 725

  Fly   876 LPAPRINERSPRISCACPTGLKLMVDGLMCVE---------DP-----------LYLPPVTRPPR 920
            |.||:|.|.||:.:||||..::|..|...||.         ||           ....|.|..|.
Zfish   726 LRAPQITEHSPKYTCACPDSMELGPDMRRCVSVKPKTTAAPDPAASTASAAEPSTTATPTTSTPV 790

  Fly   921 ARKTKPRPKSPRRRLPTGVQVGHADIRIEINDDLQLSTRLPLLPTTFVADQRPV-----KNHTQI 980
            .....|...|........:....:......:..:..||......|:..|..:|.     |..|..
Zfish   791 TSANTPTTTSRLFTTTAPITTSSSSFSTSTHSSMHRSTSTHSTSTSSTASSQPSTTAHWKQPTST 855

  Fly   981 EKTT--------------------TPSEQPDSG---------------FIALVVIASLSGFAVLL 1010
            |.||                    ..|.:..||               .|.:.::..|:  .|::
Zfish   856 ETTTDHRHTSTTITHVNSIQGANANLSHRAGSGNDHFLLGSNITVAVLGIVIPIVPILA--TVVI 918

  Fly  1011 SVLLLIGY---RYCSKRRINSMNFENPIYRKTTTTED---HFSLRKNLPARIYDHTSVMDEEYSP 1069
            .::...||   |...:|...||||:||:|||||..:|   |....:.:     .|.      |.|
Zfish   919 GLMCTGGYLVWRNWRRRNTKSMNFDNPVYRKTTEDDDDEIHIGRSEQI-----GHV------YPP 972

  Fly  1070 VIG 1072
            |.|
Zfish   973 VSG 975

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LpR1NP_001097934.2 LDLa 135..167 CDD:197566
LDLa 178..210 CDD:197566 18/30 (60%)
LDLa 219..254 CDD:238060 16/36 (44%)
LDLa 259..295 CDD:238060 14/35 (40%)
LDLa 343..373 CDD:238060 16/33 (48%)
LDLa 383..415 CDD:197566 13/31 (42%)
Ldl_recept_a 423..459 CDD:395011 22/35 (63%)
LDLa 476..504 CDD:197566 12/27 (44%)
FXa_inhibition 514..549 CDD:464251 18/34 (53%)
EGF_CA 551..581 CDD:214542 18/29 (62%)
LY 662..702 CDD:214531 12/39 (31%)
LY 704..747 CDD:214531 25/42 (60%)
LY 749..790 CDD:214531 20/40 (50%)
Ldl_recept_b 769..815 CDD:459654 23/45 (51%)
FXa_inhibition 864..905 CDD:464251 18/40 (45%)
lrp8XP_073809120.1 None
Blue background indicates that the domain is not in the aligned region.

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