DRSC/TRiP Functional Genomics Resources

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Protein Alignment LpR1 and LRP1B

DIOPT Version :10

Sequence 1:NP_001097934.2 Gene:LpR1 / 2768687 FlyBaseID:FBgn0066101 Length:1076 Species:Drosophila melanogaster
Sequence 2:NP_061027.2 Gene:LRP1B / 53353 HGNCID:6693 Length:4599 Species:Homo sapiens


Alignment Length:811 Identity:315/811 - (38%)
Similarity:442/811 - (54%) Gaps:77/811 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly   144 HSGDC------IPIRFVCDGDADCKDHS--DEQIKECKF-----IEATCSSDQFRCGNGNCIPNK 195
            ::|.|      ||...||    .|.|:.  ||....|.|     :...|.:.:|||.|.:||..:
Human   801 NNGGCSTLCLAIPGGRVC----ACADNQLLDENGTTCTFNPGEALPHICKAGEFRCKNRHCIQAR 861

  Fly   196 WRCDQESDCADGSDEANELCMN-ACPNNEFKCQTVDQCIPRSWLCDGSNDCRDKSDEAH--CRAR 257
            |:||.:.||.|||||.:..|.| :||:::||||. ::|||:.|||||:|||....||::  |.||
Human   862 WKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQN-NRCIPKRWLCDGANDCGSNEDESNQTCTAR 925

  Fly   258 TCSPDEYACKSGEGQCVPLAWMCDQSKDCSDGSDE-HNCN-QTCR-ADEFTCGNGRCIQKRWKCD 319
            ||..|:::|  |.|:|:|.||:||:..||.|.:|| .:|. .||. ..:|.|.:||||..:|.||
Human   926 TCQVDQFSC--GNGRCIPRAWLCDREDDCGDQTDEMASCEFPTCEPLTQFVCKSGRCISSKWHCD 988

  Fly   320 HDDDCGDGSDEKECPVVPC-DSVAEHTCTNGACIAKRWVCDGDPDCSDGSDERSCANVTK----T 379
            .||||||||||..| |..| |:  :..|::|.||...|.||||.||.|.|||.. .|.||    :
Human   989 SDDDCGDGSDEVGC-VHSCFDN--QFRCSSGRCIPGHWACDGDNDCGDFSDEAQ-INCTKEEIHS 1049

  Fly   380 TTPCLSHEYQCKDRITCLHHSWLCDGDRDCPDGDDEHTAN-----CKNVTCRADQFQCGDRS-CI 438
            ...|..:|:||.....|:...|.|||::||.||.||...|     |.:.|    :|.|.... ||
Human  1050 PAGCNGNEFQCHPDGNCVPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKT----KFSCWSTGRCI 1110

  Fly   439 PGHLTCNGDKDCADGSDERDCGLSLSLGINQGGC-NATSEFDCGGGQCVPLSKVCDKRKDCPDGE 502
            .....|:||.||.|.|||.||. |...|..:..| |.||       .|:...|:|:.:||||||.
Human  1111 NKAWVCDGDIDCEDQSDEDDCD-SFLCGPPKHPCANDTS-------VCLQPEKLCNGKKDCPDGS 1167

  Fly   503 DEPAGKCGINECASKNGGCMHQC-IDLKVGHHCECHEGYKLSPDKRNCQDINECEVPGKCSQICV 566
            || ...|  :||:..||||.:.| :....|..|.|.||.:|:.|.:.|:.::.|....||||:|.
Human  1168 DE-GYLC--DECSLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVCE 1229

  Fly   567 NEIGGFKCECEAGYMRDPKNHTRCKASEGHASLLLARRHDIRKIALDHMEMTSIVNSTKAATALD 631
            ......||.|..|:..|....:........|.::.:.||:||:|.|...:.:.:|...:...|||
Human  1230 QHKHTVKCSCYEGWKLDVDGESCTSVDPFEAFIIFSIRHEIRRIDLHKRDYSLLVPGLRNTIALD 1294

  Fly   632 FVFRTGMIFWSDVTTQSIYKAPIDEGNEKT---VVLTKSSVTSDGLAVDWIYNHVYFTDTHKCTI 693
            |.|...:::|:||....||:..:.|....:   ||:.....|.:||.||||..::|:.|::...|
Human  1295 FHFNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQI 1359

  Fly   694 ELTNFEGSMGKVLVKDSLDIPRSIALDPIEGWMYWSDWGAS-PRIERAGMDGSHRTTIISYDVK- 756
            |:...:||:...|:..:::.||:|||||..|.::|:||.|: ||||.|.|.|:.|.||.. |:| 
Human  1360 EVAKLDGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYK-DMKT 1423

  Fly   757 --WPNGITLDLVKKRIYWVDGKLNVISSANYDGSQRSQVLYSGEYLRHPFSITTFEDNVYWTDWD 819
              ||||:|:|..:|||.|.|.:.:.|.||.|||:...:::...|||.|||:::.:...||||||.
Human  1424 GAWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWR 1488

  Fly   820 KQAVFKANKFTGEDVEPVTAMHMLQHPMVVHVYHPYRQPDGVNHCQSVNGH--CSHLCLPAPRIN 882
            ...:.||||:||::|..:  ......|..:.:|||.|||...|.|.:.:|.  |||:||    ||
Human  1489 TNTLSKANKWTGQNVSVI--QKTSAQPFDLQIYHPSRQPQAPNPCAANDGKGPCSHMCL----IN 1547

  Fly   883 -ERSPRISCACPTGLKLMVDGLMCVEDPLYL 912
             .||  .:||||..:||..|...|.|...:|
Human  1548 HNRS--AACACPHLMKLSSDKKTCYEMKKFL 1576

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LpR1NP_001097934.2 LDLa 135..167 CDD:197566 8/30 (27%)
LDLa 178..210 CDD:197566 15/31 (48%)
LDLa 219..254 CDD:238060 19/36 (53%)
LDLa 259..295 CDD:238060 16/36 (44%)
LDLa 343..373 CDD:238060 15/29 (52%)
LDLa 383..415 CDD:197566 13/31 (42%)
Ldl_recept_a 423..459 CDD:395011 14/36 (39%)
LDLa 476..504 CDD:197566 10/27 (37%)
FXa_inhibition 514..549 CDD:464251 13/35 (37%)
EGF_CA 551..581 CDD:214542 10/29 (34%)
LY 662..702 CDD:214531 14/39 (36%)
LY 704..747 CDD:214531 20/43 (47%)
LY 749..790 CDD:214531 21/43 (49%)
Ldl_recept_b 769..815 CDD:459654 17/45 (38%)
FXa_inhibition 864..905 CDD:464251 18/43 (42%)
LRP1BNP_061027.2 LDLa 76..109 CDD:197566
FXa_inhibition 163..193 CDD:464251
NHL 282..459 CDD:302697
NHL repeat 285..321 CDD:271320
LDL-receptor class B 1 295..337
LY 319..361 CDD:214531
NHL repeat 328..367 CDD:271320
LDL-receptor class B 2 338..381
NHL repeat 371..406 CDD:271320
LDL-receptor class B 3 382..425
NHL repeat 415..445 CDD:271320
FXa_inhibition 475..516 CDD:464251
LY 548..590 CDD:214531
LDL-receptor class B 4 568..610
LY 591..630 CDD:214531
LDL-receptor class B 5 611..656
LY 637..686 CDD:214531
LDL-receptor class B 6 657..706
LY 687..729 CDD:214531
LDL-receptor class B 7 707..750
FXa_inhibition 798..833 CDD:464251 10/35 (29%)
LDLa 886..919 CDD:238060 19/33 (58%)
LDLa 926..958 CDD:197566 15/33 (45%)
LDLa 1006..1038 CDD:238060 16/33 (48%)
LDLa 1053..1088 CDD:238060 15/34 (44%)
LDLa 1097..1131 CDD:238060 14/37 (38%)
LDLa 1136..1169 CDD:197566 14/39 (36%)
FXa_inhibition 1176..1212 CDD:464251 13/35 (37%)
YncE 1282..1506 CDD:442618 88/224 (39%)
LDL-receptor class B 8 1300..1346 14/45 (31%)
LY 1327..1367 CDD:214531 13/39 (33%)
LDL-receptor class B 9 1347..1389 14/41 (34%)
LY 1371..1414 CDD:214531 20/42 (48%)
LDL-receptor class B 10 1390..1436 23/46 (50%)
LDL-receptor class B 11 1437..1480 17/42 (40%)
LDL-receptor class B 12 1481..1522 16/42 (38%)
LDL-receptor class B 13 1618..1660
Ldl_recept_b 1618..1658 CDD:459654
LY 1641..1683 CDD:214531
LDL-receptor class B 14 1661..1704
LDL-receptor class B 15 1705..1744
Ldl_recept_b 1705..1742 CDD:459654
LY <1735..1766 CDD:214531
LDL-receptor class B 16 1745..1787
FXa_inhibition 1838..1874 CDD:464251
Vgb 1921..>2110 CDD:443399
LDL-receptor class B 17 1922..1964
LY 1947..1987 CDD:214531
LDL-receptor class B 28 1965..2007
LDL-receptor class B 19 2008..2051
LY 2033..2075 CDD:214531
LDL-receptor class B 20 2052..2095
FXa_inhibition 2147..2182 CDD:464251
LDL-receptor class B 21 2239..2280
LDL-receptor class B 22 2281..2329
LDL-receptor class B 23 2330..2374
Ldl_recept_b 2330..2372 CDD:459654
LY 2355..2397 CDD:214531
LDL-receptor class B 24 2375..2416
LDL-receptor class B 25 2417..2459
FXa_inhibition 2468..2502 CDD:464251
LDLa 2514..2543 CDD:238060
LDLa 2552..2586 CDD:238060
LDLa 2591..2625 CDD:238060
LDLa 2645..2674 CDD:238060
LDLa 2682..2716 CDD:238060
LDLa 2720..2753 CDD:238060
LDLa 2760..2793 CDD:197566
LDLa 2844..2877 CDD:197566
LDLa 2891..2925 CDD:238060
FXa_inhibition 2937..2966 CDD:464251
EGF_CA 2968..2998 CDD:214542
LY 3035..3079 CDD:214531
LDL-receptor class B 26 3055..3098
LY 3080..3118 CDD:214531
LDL-receptor class B 27 3099..3141
LY 3123..3164 CDD:214531
LDL-receptor class B 28 3142..3185
LY 3167..3206 CDD:214531
LDL-receptor class B 29 3186..3224
LDL-receptor class B 30 3225..3268
FXa_inhibition 3277..3313 CDD:464251
LDLa 3317..3348 CDD:197566
LDLa 3357..3391 CDD:238060
LDLa 3396..3431 CDD:238060
LDLa 3436..3471 CDD:238060
LDLa 3476..3510 CDD:238060
LDLa 3515..3549 CDD:238060
LDLa 3553..3587 CDD:238060
LDLa 3594..3628 CDD:238060
LDLa 3632..3667 CDD:238060
LDLa 3674..3706 CDD:238060
LDLa 3721..3751 CDD:238060
LDLa 3762..3796 CDD:238060
EGF_CA 3844..3878 CDD:214542
LDL-receptor class B 31 3933..3980
LY <3971..>3990 CDD:214531
LDL-receptor class B 32 3981..4038
LDL-receptor class B 33 4039..4082
Ldl_recept_b 4039..4080 CDD:459654
LY 4063..4102 CDD:214531
LDL-receptor class B 34 4083..4127
EGF_CA 4250..4284 CDD:238011
Endocytosis signal. /evidence=ECO:0000255 4492..4495
Endocytosis signal. /evidence=ECO:0000255 4559..4562
Blue background indicates that the domain is not in the aligned region.

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