DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LpR1 and LpR2

DIOPT Version :9

Sequence 1:	NP_001097934.2	Gene:	LpR1 / 2768687	FlyBaseID:	FBgn0066101	Length:	1076	Species:	Drosophila melanogaster
Sequence 2:	NP_001097928.1	Gene:	LpR2 / 43105	FlyBaseID:	FBgn0051092	Length:	1064	Species:	Drosophila melanogaster

Alignment Length:	1124	Identity:	691/1124 - (61%)
Similarity:	793/1124 - (70%)	Gaps:	163/1124 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SRSTSTAS---ETTKTA---IKSTTSSKSPVTFGNLGEKRRAEQLFRCA-CANFNLLLLTLMLGF 62
            |||:|::|   |.:||:   ..::|..:|.|           :||...: .::|:||.:|.:|..
  Fly    29 SRSSSSSSGCREPSKTSGFFYSASTHYQSKV-----------QQLISFSFTSSFHLLFITCILSI 82

  Fly    63 GKCCTATPTPLNTPSTNTPTSAVSPHN---------------PQTLDE----------------- 95
            .|.|.|........:..|||::...||               ..|||:
  Fly    83 SKFCNAAAVNAAHVTAATPTASEIMHNLSGSALLERLKASTLGPTLDQLKHLAPAAANSISPGTG 147

  Fly    96 SG----------SLSKVIDGKAFINMGFKFLNVSGKIGTPLGIGQSLEAKCDEKQFQCHSGDCIP 150
            ||          |::.|::|..     .|||||||||||||.|...|...||||||||.:|:|||
  Fly   148 SGMGIGMGHFGSSINSVLNGNP-----LKFLNVSGKIGTPLDISLGLSNYCDEKQFQCSTGECIP 207

  Fly   151 IRFVCDGDADCKDHSDEQIKECKFIEATCSSDQFRCGNGNCIPNKWRCDQESDCADGSDEANELC 215
            |||||||.:||.|||||:::||||.|:|||.:|||||||.|||.:|.||:|:||||||||:.
  Fly   208 IRFVCDGSSDCPDHSDERLEECKFTESTCSQEQFRCGNGKCIPRRWVCDRENDCADGSDEST--- 269

  Fly   216 MNACPNNEFKCQTVDQCIPRSWLCDGSNDCRDKSDEAHCRARTCSPDEYACKSGEGQCVPLAWMC 280
                                                :.||:.||||:|:|||||||:|:||:|||
  Fly   270 ------------------------------------SQCRSHTCSPEEFACKSGEGECIPLSWMC 298

  Fly   281 DQSKDCSDGSDEHNCNQTCRADEFTCGNGRCIQKRWKCDHDDDCGDGSDEKEC-PVVPCDSVAEH 344
            ||:|||.|||||..||:|||:||||||||||||.|:|||.|||||||||||.| ....|.| ...
  Fly   299 DQNKDCRDGSDEAQCNRTCRSDEFTCGNGRCIQNRFKCDDDDDCGDGSDEKNCGEKAKCGS-NFF 362

  Fly   345 TCTNGACIAKRWVCDGDPDCSDGSDERSCANVTKTTTPCLSHEYQCKDRITCLHHSWLCDGDRDC 409
            .|.:|.||..:||||||.||.:|.||.....|:.... |.:.|:||.|||||||.||:|||:.||
  Fly   363 ACKSGPCIPNQWVCDGDSDCRNGEDEMQNCTVSLLNF-CQAGEFQCSDRITCLHKSWVCDGEADC 426

  Fly   410 PDGDDEHTANCKNVTCRADQFQCGDRSCIPGHLTCNGDKDCADGSDERDCGLSLSLGINQGGCNA 474
            |||:||..:||..|:||.|||||.|:|||.|||||||.:||||||||..|.:|.:    ...|||
  Fly   427 PDGEDESQSNCLKVSCRPDQFQCNDQSCIAGHLTCNGKRDCADGSDEIMCDISAT----PRTCNA 487

  Fly   475 TSEFDCGGGQCVPLSKVCDKRKDCPDGEDEPAGKCGINECASKNGGCMHQCIDLKVGHHCECHEG 539
            |:|||||||.|:|.:|||::|||||:||||||||||||||:||||||||||::|:||:.||||:|
  Fly   488 TTEFDCGGGLCIPNAKVCNRRKDCPNGEDEPAGKCGINECSSKNGGCMHQCVNLEVGYRCECHDG 552

  Fly   540 YKLSPDKRNCQDINECEVPGKCSQICVNEIGGFKCECEAGYMRDPKNHTRCKASEGHASLLLARR 604
            |||..|:..|.||:|||.||.|||:||||||.|||||||||||..||||||||||||||||||||
  Fly   553 YKLGADQHTCVDIDECETPGICSQVCVNEIGAFKCECEAGYMRLLKNHTRCKASEGHASLLLARR 617

  Fly   605 HDIRKIALDHMEMTSIVNSTKAATALDFVFRTGMIFWSDVTTQSIYKAPIDEGNEKTVVLTKSSV 669
            |||||||||..|||||||||||||||||||||||||||||.|||||||||||||::|||||||||
  Fly   618 HDIRKIALDRPEMTSIVNSTKAATALDFVFRTGMIFWSDVATQSIYKAPIDEGNDRTVVLTKSSV 682

  Fly   670 TSDGLAVDWIYNHVYFTDTHKCTIELTNFEGSMGKVLVKDSLDIPRSIALDPIEGWMYWSDWGAS 734
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Fly   683 TSDGLAVDWIYNHVYFTDTHKCTIELTNFEGSMGKVLVKDSLDIPRSIALDPIEGWMYWSDWGAS 747

  Fly   735 PRIERAGMDGSHRTTIISYDVKWPNGITLDLVKKRIYWVDGKLNVISSANYDGSQRSQVLYSGEY 799
            ||||||||||:|||.||:||||||||||||||:||:||||||||.|||:|||||||.||||||||
  Fly   748 PRIERAGMDGTHRTAIITYDVKWPNGITLDLVQKRLYWVDGKLNTISSSNYDGSQRHQVLYSGEY 812

  Fly   800 LRHPFSITTFEDNVYWTDWDKQAVFKANKFTGEDVEPVTAMHMLQHPMVVHVYHPYRQPDGVNHC 864
            ||||||||||||.|||||||||||||||||.|.|||||||.|||:||||||||||||||||||||
  Fly   813 LRHPFSITTFEDYVYWTDWDKQAVFKANKFNGMDVEPVTATHMLEHPMVVHVYHPYRQPDGVNHC 877

  Fly   865 QSVNGHCSHLCLPAPRINERSPRISCACPTGLKLMVDGLMCVEDPLYLPPVTRPPRARKTKPRPK 929
            |||||||||||||||||||||||||||||||||||.|||||||| |.:|.|           ||.
  Fly   878 QSVNGHCSHLCLPAPRINERSPRISCACPTGLKLMPDGLMCVED-LGIPTV-----------RPT 930

  Fly   930 SPRRRLPTGVQVGHADIRIEINDDLQLSTRLPLLPTTFVAD---QRPVKNHT---------QIEK 982
            :|..|              .|......:|:||       .|   :.||:..|         |:.|
  Fly   931 APMHR--------------TIEQSSNSTTKLP-------QDGYSETPVETKTGNNRTDTSNQVHK 974

  Fly   983 TTTPSEQPDSGFIALVVIASLSGFAVLLSVLLLIGYRYCSKRRINSMNFENPIYRKTTTTEDHFS 1047
            :...||. |...|||.|||||:|.|::.||:.:: ||.|: |.:||||||||:|.|  |||||||
  Fly   975 SDAESEN-DYVEIALHVIASLAGTALVASVIYVV-YRRCT-RAVNSMNFENPVYHK--TTEDHFS 1034

  Fly  1048 LRKNLPARIYDHTSVMDEE 1066
            |.||....||  .:..|||
  Fly  1035 LEKNGTPHIY--AAANDEE 1051

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LpR1	NP_001097934.2	LDLa	135..167	CDD:197566	24/31 (77%)
		LDLa	178..210	CDD:197566	23/31 (74%)
		LDLa	219..254	CDD:238060	0/34 (0%)
		LDLa	259..295	CDD:238060	27/35 (77%)
		LDLa	343..373	CDD:238060	15/29 (52%)
		LDLa	383..415	CDD:197566	21/31 (68%)
		Ldl_recept_a	423..459	CDD:278486	27/35 (77%)
		LDLa	476..504	CDD:197566	19/27 (70%)
		FXa_inhibition	514..549	CDD:291342	23/34 (68%)
		EGF_CA	551..581	CDD:214542	24/29 (83%)
		LY	662..702	CDD:214531	39/39 (100%)
		LY	704..747	CDD:214531	41/42 (98%)
		LY	749..790	CDD:214531	34/40 (85%)
		FXa_inhibition	864..905	CDD:291342	39/40 (98%)
LpR2	NP_001097928.1	LDLa	193..224	CDD:197566	24/30 (80%)
		LDLa	235..267	CDD:197566	23/31 (74%)
		LDLa	277..313	CDD:238060	27/35 (77%)
		LDLa	356..388	CDD:197566	15/32 (47%)
		LDLa	400..432	CDD:197566	21/31 (68%)
		LDLa	442..476	CDD:238060	26/33 (79%)
		LDLa	484..517	CDD:197566	23/32 (72%)
		FXa_inhibition	527..562	CDD:291342	23/34 (68%)
		EGF_CA	564..594	CDD:214542	24/29 (83%)
		LY	675..715	CDD:214531	39/39 (100%)
		LY	717..760	CDD:214531	41/42 (98%)
		LY	763..803	CDD:214531	34/39 (87%)
		FXa_inhibition	877..918	CDD:291342	39/40 (98%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468397
Domainoid	1	1.000	57	1.000	Domainoid score	I10830
eggNOG	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H443
Inparanoid	1	1.050	720	1.000	Inparanoid score	I618
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D179614at33208
OrthoFinder	1	1.000	-	-		FOG0002088
OrthoInspector	1	1.000	-	-		mtm6597
orthoMCL	1	0.900	-	-		OOG6_103130
Panther	1	1.100	-	-	P	PTHR24270
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7933
SonicParanoid	1	1.000	-	-		X1052
	12	11.930