DRSC/TRiP Functional Genomics Resources

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Protein Alignment LpR1 and LRP3

DIOPT Version :10

Sequence 1:NP_001097934.2 Gene:LpR1 / 2768687 FlyBaseID:FBgn0066101 Length:1076 Species:Drosophila melanogaster
Sequence 2:XP_005259002.1 Gene:LRP3 / 4037 HGNCID:6695 Length:785 Species:Homo sapiens


Alignment Length:621 Identity:140/621 - (22%)
Similarity:191/621 - (30%) Gaps:251/621 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 EKRRAEQLFRCACANFNLLLLTLMLGF--GKCCTATPT-----------------------PLNT 75
            |||.|..|.....|...|.::.|:..|  |:..:|.|.                       |||.
Human     2 EKRAAAGLEGAPGARAQLAVVCLVNIFLTGRLSSAVPALAACSGKLEQHTERRGVIYSPAWPLNY 66

  Fly    76 PSTNTPTSAVSPHNPQTLDESGSLSKVIDGKA--FINMGFKFLNVSGKIGTPLGIGQSLEAKCDE 138
            |             |.|     :.|..|.|..  .|.:.|:..:|                   |
Human    67 P-------------PGT-----NCSWYIQGDRGDMITISFRNFDV-------------------E 94

  Fly   139 KQFQCH-------------------SGDCIPIRFVCDGD-------ADCKDHSDEQIKECKFI-- 175
            :..||.                   .|..||..|:...|       :|.......|.....:|  
Human    95 ESHQCSLDWLLLGPAAPPRQEAFRLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSYIRG 159

  Fly   176 ---EATCSSDQFRCGNGNCIPNKWRCDQESDCADGSDEANELCM--------NACPNNEFKCQTV 229
               :|:|.:|:|||.||.|:|..|:|:...:|.|||||.|  |.        :.||...|.|...
Human   160 KLGQASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGN--CSAPASEPPGSLCPGGTFPCSGA 222

  Fly   230 --DQCIPRSWLCDGSNDCRDKSDEAHCRARTC------------SPDEYACKSGEGQCVPLAWMC 280
              .:|:|....|||..||.|.||||.|....|            |||.:....|... :...|:.
Human   223 RSTRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAARGPSD-LHCTWLV 286

  Fly   281 DQ----------------------------------------------SKDCSDG---------- 289
            |.                                              |.:.:.|          
Human   287 DTQDSRRVLLQLELRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQGRLTVAYHARA 351

  Fly   290 -SDEHNCNQT------CRADEFTCGNGR-----------CIQKRWKCDHDDDCGDGSDEKECPVV 336
             |..|..|.|      |...|..||:..           |..:..:||....|..|.||:.||..
Human   352 RSAGHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCFSEPQRCDGWWHCASGRDEQGCPAC 416

  Fly   337 PCDSVAEHTCTNGA--CIAKRWVCDGDPDCSDGSDERSCANVTKTTTPCLSHEYQCKDRITCLHH 399
            |.|   ::.|..|:  |......|:....|.||:||::|.:       |....:.|...: |:..
Human   417 PPD---QYPCEGGSGLCYTPADRCNNQKSCPDGADEKNCFS-------CQPGTFHCGTNL-CIFE 470

  Fly   400 SWLCDGDRDCPDGDDEHTANC------KNVTCRADQFQCGDRSCIPGHLTCNGDKDCADGSDERD 458
            :|.|||..||.||.|||  .|      |.:|           :.:.|.|.               
Human   471 TWRCDGQEDCQDGSDEH--GCLAAVPRKVIT-----------AALIGSLV--------------- 507

  Fly   459 CGLSLSLGINQGGCN------ATSEFDCGGGQ-CVP 487
            |||.|.:.:   ||.      .|.|:.....| |.|
Human   508 CGLLLVIAL---GCAFKLYSLRTQEYRSRAAQSCRP 540

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LpR1NP_001097934.2 LDLa 135..167 CDD:197566 9/57 (16%)
LDLa 178..210 CDD:197566 15/31 (48%)
LDLa 219..254 CDD:238060 16/36 (44%)
LDLa 259..295 CDD:238060 11/104 (11%)
LDLa 343..373 CDD:238060 9/31 (29%)
LDLa 383..415 CDD:197566 11/31 (35%)
Ldl_recept_a 423..459 CDD:395011 3/35 (9%)
LDLa 476..504 CDD:197566 4/13 (31%)
FXa_inhibition 514..549 CDD:464251
EGF_CA 551..581 CDD:214542
LY 662..702 CDD:214531
LY 704..747 CDD:214531
LY 749..790 CDD:214531
Ldl_recept_b 769..815 CDD:459654
FXa_inhibition 864..905 CDD:464251
LRP3XP_005259002.1 CUB 43..156 CDD:238001 22/149 (15%)
LDLa 166..200 CDD:238060 18/35 (51%)
LDLa 212..249 CDD:238060 16/36 (44%)
CUB 254..364 CDD:238001 13/110 (12%)
LDLa 416..452 CDD:238060 11/38 (29%)
LDLa 455..489 CDD:238060 14/36 (39%)
PHA03247 <527..772 CDD:223021 5/14 (36%)
Blue background indicates that the domain is not in the aligned region.

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