DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LpR1 and ldlrb

DIOPT Version :9

Sequence 1:	NP_001097934.2	Gene:	LpR1 / 2768687	FlyBaseID:	FBgn0066101	Length:	1076	Species:	Drosophila melanogaster
Sequence 2:	XP_017212215.1	Gene:	ldlrb / 393460	ZFINID:	ZDB-GENE-040426-1254	Length:	906	Species:	Danio rerio

Alignment Length:	957	Identity:	325/957 - (33%)
Similarity:	476/957 - (49%)	Gaps:	153/957 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 FRCGNGNCIPNKWRCDQESDCADGSDEANELCM--------NACPNNEF--------------KC 226
            |.|||.       |..||:.|.       ..|.        :|.|:...              .|
Zfish    28 FCCGNA-------RRSQEAVCP-------VFCQILVRHTPDDATPDTHTHTHTHTHTHTHTHQSC 78

  Fly   227 QTVDQCIPRSWLCDGSNDCRDKSDEAHCRA------------RTCSPDEYACKSGEGQCVPLAWM 279
            .:|...:.......||:..|.|....|..:            :||...:::|.....|||...|.
Zfish    79 PSVKHTLSAPLFIRGSDTDRVKHTHTHTHSPHANDSSASAGQKTCVSGQFSCGDRLNQCVSSRWR 143

  Fly   280 CDQSKDCSDGSDEHNCNQ-TCRADEFTCGNGRCIQKRWKCDHDDDCGDGSDEKECPVVPCDSVAE 343
            ||...||.:|:||.||.| .|.|:||.||:|:|:...:.||.|.||.|||||..||      ...
Zfish   144 CDGKSDCENGADEQNCAQKNCSAEEFRCGSGQCVSLSFVCDGDSDCSDGSDEAACP------THT 202

  Fly   344 HTC--------TNGACIAKRWVCDGDPDCSDGSDE--RSCANVTKTTTPCLSHEYQCKDRITCLH 398
            |||        :...|:.:.|.|||||||:|||||  :.|.......  |...:.||:.. .|:.
Zfish   203 HTCGPTAFQCSSPAVCVPQLWACDGDPDCADGSDEWLQHCGGARARV--CPEQQMQCRSG-ECVP 264

  Fly   399 HSWLCDGDRDCPDGDDEHTANCKNVTCRADQFQCGDRSCIPGHLTCNGDKDCADGSDERDCGLSL 463
            .||.|||..||.|..||.  ||...|||.|:|.|.|..|:||...|:|..||.|.|||.|| ..:
Zfish   265 DSWRCDGAFDCSDRSDED--NCTVHTCRPDEFLCADGGCVPGLRQCDGHPDCGDRSDELDC-TPV 326

  Fly   464 SLGINQGGCNATSEFDCGGGQCVPLSKVCDKRKDCPDGEDEPAGKCGINECASKNGGCMHQCIDL 528
            |:      |:|.|.|.|..|:|:...:|||.::||.|..|||...|.:|||.|.||||.|.|:||
Zfish   327 SV------CDAPSRFKCSSGECISAERVCDGQRDCGDASDEPIRDCNVNECLSSNGGCSHLCVDL 385

  Fly   529 KVGHHCECHEGYKLSPDKRNCQDINECEVPGKCSQICVNEIGGFKCECEAGYMRDPKNHTR-CKA 592
            ::|..|.|..|::|: :..:|:|::||.....|||:|||..|.:||.|..||..|  :.|| |:|
Zfish   386 RLGFECSCPAGFRLA-NHTHCEDVDECVDADACSQMCVNLPGSYKCVCAEGYELD--HMTRDCRA 447

  Fly   593 SEG-HASLLLARRHDIRKIALDHMEMTSIVNSTKAATALDFVFRTGMIFWSDVTTQSIYKAPIDE 656
            :.| .|.||.:.||::||:||...|.|:::...:...|||...:...::|||::.:.||......
Zfish   448 ATGPEAFLLFSTRHEVRKLALGSREYTAVLRQQRNVVALDVDVQRDTLYWSDLSQRKIYSTTASN 512

  Fly   657 GNEKTVVLTKSSVTSDGLAVDWIYNHVYFTDTHKCTIELTNFEGSMGKVLVKDSLDIPRSIALDP 721
            ..:...|:.......:||||||::.::|:||:.:.::.:...:||..|.|: ..|..||:|.|||
Zfish   513 PTQNRTVIDSWISRPEGLAVDWVHRNIYWTDSEQRSVSVATADGSKRKTLI-HGLQNPRAIVLDP 576

  Fly   722 IEGWMYWSDWGASPRIERAGMDGSHRTTIISYDVKWPNGITLDLVKKRIYWVDGKLNVISSANYD 786
            ...:|:|||||.|.||||.|::|:.||.:::.::.|||||.||::.:|:||||.||:.:||...|
Zfish   577 QSNFMFWSDWGVSARIERCGLNGADRTALVTDNIVWPNGIALDVLGRRLYWVDSKLHTLSSIGVD 641

  Fly   787 GSQRSQVLYSGEYLRHPFSITTFEDNVYWTDWDKQAVFKANKFTGEDVEPVTAMHMLQHPMVVHV 851
            |:.|..:::..:.|.||.::..||:.|:|||.....::.||:.||.::..|  :..||.|..:.:
Zfish   642 GNGRHTLIHDQQTLPHPLALAVFEEKVFWTDVANHGIWSANRLTGHEISAV--LKHLQSPEDIVL 704

  Fly   852 YHPYRQPDGVNHCQS---VNGHCSHLCLPAPRINERSPRISCACPTGLKLMVDGLMCV------- 906
            ||...||.|.:.|:.   :||.|..||||||.||..||:.:||||..:.|..|...||
Zfish   705 YHSLTQPSGRDWCRESALLNGGCEFLCLPAPAINTHSPKYTCACPDHMTLAEDMRTCVPGLNITA 769

  Fly   907 ----EDPLYLPPVT--RPPRARKTKPRPKSPRRRLPTGVQVGHADIRIEINDDLQLSTRLPLLPT 965
                .||  .||.|  .|.|||.|                                .||....||
Zfish   770 APGHTDP--SPPTTTATPTRARTT--------------------------------PTRAGATPT 800

  Fly   966 TFVA---DQRPVKNH----TQIEKTTTPSEQPDSGFIALVVIASLSGFAVLLSVLLLIGYRYCSK 1023
            ...|   :||....|    .|:|..::||:.|...:|.|.::|     ..:|::..::.:|....
Zfish   801 RAAAVTFEQRIGDAHRGVSEQLEPVSSPSQHPTVLYITLPIVA-----VCVLALAAVLIWRQWRL 860

  Fly  1024 RRINSMNFENPIYRKTTTTEDHFSLRKNLPARIYDHTSV----MDEE 1066
            :..|:::|.||:|:|  |::|..::.::.....|.|.|.    :||:
Zfish   861 KNTNTIHFTNPVYQK--TSDDTVAIFRSPSQDGYTHPSCQMVSVDED 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LpR1	NP_001097934.2	LDLa	135..167	CDD:197566
		LDLa	178..210	CDD:197566	8/25 (32%)
		LDLa	219..254	CDD:238060	7/48 (15%)
		LDLa	259..295	CDD:238060	13/35 (37%)
		LDLa	343..373	CDD:238060	17/39 (44%)
		LDLa	383..415	CDD:197566	12/31 (39%)
		Ldl_recept_a	423..459	CDD:278486	18/35 (51%)
		LDLa	476..504	CDD:197566	11/27 (41%)
		FXa_inhibition	514..549	CDD:291342	15/34 (44%)
		EGF_CA	551..581	CDD:214542	14/29 (48%)
		LY	662..702	CDD:214531	11/39 (28%)
		LY	704..747	CDD:214531	22/42 (52%)
		LY	749..790	CDD:214531	18/40 (45%)
		FXa_inhibition	864..905	CDD:291342	20/43 (47%)
ldlrb	XP_017212215.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D179614at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920