DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LpR1 and Lrp8

DIOPT Version :9

Sequence 1:	NP_001097934.2	Gene:	LpR1 / 2768687	FlyBaseID:	FBgn0066101	Length:	1076	Species:	Drosophila melanogaster
Sequence 2:	XP_006238632.1	Gene:	Lrp8 / 362558	RGDID:	1305729	Length:	1013	Species:	Rattus norvegicus

Alignment Length:	934	Identity:	351/934 - (37%)
Similarity:	500/934 - (53%)	Gaps:	84/934 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 IKECKFIEATCSSDQFRCGNGNCIPNKWRCDQESDCADGSDEANELCMNACPNNEFKCQTVDQCI 233
            :|||:       .|||||.|..|||:.||||:::||:|.||| ::.....|.:::|.|.. ..||
  Rat    41 VKECE-------EDQFRCRNERCIPSVWRCDEDNDCSDNSDE-DDCPKRTCTDSDFTCDN-GHCI 96

  Fly   234 PRSWLCDGSNDCRDKSDE--AHCRARTCSPDEYACKSGEGQCVPLAWMCDQSKDCSDGSDEHNCN 296
            |..|.|||..:|.|.|||  |.|.:..|..::.:|.....:|||.:|.||..|||..|:||..|.
  Rat    97 PERWKCDGEEECPDGSDESKATCSSEECPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCP 161

  Fly   297 QTCRADEFTCGNGRCIQKRWKCDHDDDCGDGSDEKECPVVPCDSVAEHTC-TNGACIAKRWVCDG 360
            ..|...||.|.|..|:...:.||.||||||||||:.|....|.. .|..| ..|.||.:||||||
  Rat   162 TLCAPHEFQCSNRSCLASVFVCDGDDDCGDGSDERGCSDPACPP-REFRCGGGGTCIPERWVCDG 225

  Fly   361 DPDCSDGSDE------RSCANVTKTTTPCL-SHEYQCKDRITCLHHSWLCDGDRDCPDGDDEHTA 418
            ..||.|.|||      |:....|.|...|. :.::.|:.. .|:|..|.|||||||.|..||  |
  Rat   226 QFDCEDRSDEAAELCGRAGQGTTATPAACAPTTQFTCRSG-ECIHLGWRCDGDRDCKDKSDE--A 287

  Fly   419 NCKNV-TCRADQFQCGDRSCIPGHLTCNGDKDCADGSDERDCGLSLSLGINQGGCNATSEFDCGG 482
            :|... .||.:.|||||.:||.....||.::||.|||||..|       :.:..|.....|.|..
  Rat   288 DCSAPGPCRENDFQCGDGTCILAIKRCNQERDCLDGSDEAGC-------LQESTCEGPRRFQCKS 345

  Fly   483 GQCVPLSKVCDKRKDCPDGEDEPAGKC-------------GINECASKNGGCMHQCIDLKVGHHC 534
            |:||...||||.::||.|..|||...|             |:|||...||||.|.|.|||:|..|
  Rat   346 GECVDGGKVCDDQRDCRDWSDEPQKVCVAPIFQGNRRRPRGLNECLHNNGGCSHICTDLKIGFEC 410

  Fly   535 ECHEGYKLSPDKRNCQDINECEVPGKCSQICVNEIGGFKCECEAGYMRD--PKNHTRCKASEGHA 597
            .|..|::|. |::.|.||:||:.|..|||||||..|.|||||..||..|  .||   |||..|.:
  Rat   411 TCPAGFQLL-DQKTCGDIDECQDPDACSQICVNYKGYFKCECHPGYEMDTLTKN---CKAVAGRS 471

  Fly   598 -SLLLARRHDIRKIALDHMEMTSIVNSTKAATALDFVFRTGMIFWSDVTTQSIYKAPIDEG---N 658
             ||:...||::|:|.|...:.:.::...|...|||....|..|:|.|::.:.||.|.:|:.   :
  Rat   472 PSLIFTNRHEVRRIDLVKRDYSRLIPMLKNVVALDVEVDTNRIYWCDLSYRKIYSAHMDKASIPD 536

  Fly   659 EKTVVLTKSSVTSDGLAVDWIYNHVYFTDTHKCTIELTNFEGSMGKVLVKDSLDIPRSIALDPIE 723
            |:.|::.:...:.:||||||::.|:|:||:...|:.:...:|.....|....|..||:||:||:.
  Rat   537 EQVVLIGEQLHSPEGLAVDWVHKHIYWTDSGNKTVSVATTDGRRRCTLFNRDLSEPRAIAVDPLR 601

  Fly   724 GWMYWSDWGASPRIERAGMDGSHRTTIISYDVKWPNGITLDLVKKRIYWVDGKLNVISSANYDGS 788
            |:|||||||...:||:||::|:.|.|::|.:::|||||||||:.:|:||||.||:.:||.:::|.
  Rat   602 GFMYWSDWGFQAKIEKAGLNGADRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFNGG 666

  Fly   789 QRSQVLYSGEYLRHPFSITTFEDNVYWTDWDKQAVFKANKFTGEDVEPVTAMHMLQHPMVVHVYH 853
            .|..:::|.::|.|||.:..|||.|:|||.:.:|:|.||:..|.::..:.  ..|.:|..:.::|
  Rat   667 NRKMLIFSTDFLSHPFGVAVFEDKVFWTDLENEAIFSANRLNGLEISILA--ENLNNPHDIVIFH 729

  Fly   854 PYRQPDGVNHCQ---SVNGHCSHLCLPAPRINERSPRISCACPTGLKLMVDGLMCVEDPLYLPPV 915
            ..:||...:.|:   ..||.|.:||||||:|:..||:.:||||..:.|..|...|.
  Rat   730 ELKQPKAADACELSAQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCY--------- 785

  Fly   916 TRPPRARKTKPRPKSPRRRLPTGVQVGHADIRIEINDDLQLSTRLPLLPTTFVADQRPVKNHTQI 980
             |.|.:..|.....:..|.:|  ...|.....|..:.....||.:|.............|.|:..
  Rat   786 -RAPPSTSTTTLASAMTRTVP--ATTGAPGTTIHDSTYQNHSTEMPSQTAAVPHSVNIPKAHSTS 847

  Fly   981 EKTTTPSEQPDS-------GFIALVVIASLSGF---AVLLSVLLLIGY---RYCSKRRINSMNFE 1032
            ..|.:|:....|       ..:...|.|::.|.   .|::::|.:.||   |...::...||||:
  Rat   848 PSTLSPATSNHSQHYGNEGSQMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFD 912

  Fly  1033 NPIYRKTTTTEDHFSLRKNLPARI 1056
            ||:|||||..|:...|.....|:|
  Rat   913 NPVYRKTTEEEEEDELHIGRTAQI 936

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LpR1	NP_001097934.2	LDLa	135..167	CDD:197566
		LDLa	178..210	CDD:197566	17/31 (55%)
		LDLa	219..254	CDD:238060	16/36 (44%)
		LDLa	259..295	CDD:238060	14/35 (40%)
		LDLa	343..373	CDD:238060	18/36 (50%)
		LDLa	383..415	CDD:197566	13/32 (41%)
		Ldl_recept_a	423..459	CDD:278486	18/36 (50%)
		LDLa	476..504	CDD:197566	12/27 (44%)
		FXa_inhibition	514..549	CDD:291342	16/34 (47%)
		EGF_CA	551..581	CDD:214542	19/29 (66%)
		LY	662..702	CDD:214531	13/39 (33%)
		LY	704..747	CDD:214531	21/42 (50%)
		LY	749..790	CDD:214531	21/40 (53%)
		FXa_inhibition	864..905	CDD:291342	19/43 (44%)
Lrp8	XP_006238632.1	LDLa	44..78	CDD:238060	20/41 (49%)
		LDLa	82..114	CDD:197566	13/32 (41%)
		LDLa	124..160	CDD:238060	14/35 (40%)
		LDLa	203..235	CDD:197566	16/32 (50%)
		LDLa	256..289	CDD:238060	15/35 (43%)
		LDLa	295..329	CDD:238060	18/33 (55%)
		LDLa	333..369	CDD:294076	15/35 (43%)
		FXa_inhibition	390..424	CDD:291342	16/34 (47%)
		EGF_CA	426..456	CDD:214542	19/29 (66%)
		LY	495..530	CDD:214531	11/34 (32%)
		LY	540..581	CDD:214531	13/40 (33%)
		Ldl_recept_b	602..642	CDD:278487	22/39 (56%)
		LY	626..668	CDD:214531	21/41 (51%)
		Ldl_recept_b	689..728	CDD:278487	12/40 (30%)
		FXa_inhibition	747..784	CDD:291342	18/36 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	55	1.000	Domainoid score	I10838
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	710	1.000	Inparanoid score	I619
OMA	1	1.010	-	-		QHG49125
OrthoDB	1	1.010	-	-		D179614at33208
OrthoFinder	1	1.000	-	-		FOG0002088
OrthoInspector	1	1.000	-	-		mtm9029
orthoMCL	1	0.900	-	-		OOG6_103130
Panther	1	1.100	-	-	O	PTHR24270
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1052
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.980