DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LpR1 and Ndg

DIOPT Version :9

Sequence 1:	NP_001097934.2	Gene:	LpR1 / 2768687	FlyBaseID:	FBgn0066101	Length:	1076	Species:	Drosophila melanogaster
Sequence 2:	NP_610575.1	Gene:	Ndg / 36089	FlyBaseID:	FBgn0026403	Length:	1350	Species:	Drosophila melanogaster

Alignment Length:	967	Identity:	219/967 - (22%)
Similarity:	353/967 - (36%)	Gaps:	280/967 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 DESG-SLSKVIDGKAFINMGFKFLNVSGKIGTPLGIGQSLEAK-CDEKQFQC-HSGDCIPIR--F 153
            ||:. |.:||:...:.:.:.:...:.:.:||....:|.:.|:. |::....| .:..|:|..  :
  Fly   505 DEADPSATKVLQKISKVALDYVERDQALRIGAMSKVGVTPESNACNDGTADCVENSVCVPYEDTY 569

  Fly   154 VCDGDADCKDHSDEQIKECKFIEATCSSDQFRCGNGNCIPNKWRCDQESDCADGSDEANELCMNA 218
            .|    ||......|:.| :.:|.....|:  |..|:.:     ||:.:.|.:.....|..|...
  Fly   570 RC----DCYHGFAAQLDE-RGVEVCLDIDE--CATGSHV-----CDENAVCDNTEGGFNCYCTEG 622

  Fly   219 CPNNEFKC---QTVD----------QCIPRS--------WLCDGSNDCRDKSDEAHCRARTCSPD 262
            ...|.::|   .|.|          |..|.|        :...|.:..|::.|:.:.:.......
  Fly   623 FEGNGYRCLSNSTADNIEYPPAVEGQAEPTSEPSPNPSPYPDQGQDQEREREDDQYPQPNPYPYP 687

  Fly   263 EYACKSGEGQCVPLAWMCDQSKDCSDGSDEHNCNQTCRADEFTC----------GNGRC---IQK 314
            |........:|    :.|.:..||..|  ...|::....|.:||          .||||   :.:
  Fly   688 EEQIPQHPDEC----YRCSKDADCYQG--RCTCHEGFDGDGYTCTNICGHGEVWENGRCEPLLLE 746

  Fly   315 RWKCDHDDD--CGDGSDEKECP-------------------------VVPCDSVAEHTCTNGACI 352
            |    ||.|  | |...|..||                         ::||| |.|:...|..|
  Fly   747 R----HDVDPLC-DALGECRCPYGYELSEDSQRCTYVQEFDGERNADLIPCD-VDENCHINATC- 804

  Fly   353 AKRW-------VCDGDP-------DCSDGSDERSCANVTKTTTPCLSHEYQCKDRITCLHHSWLC 403
              .|       :|...|       :|...||: |||     ..|.:     |.....|::...|.
  Fly   805 --NWYGQELRHICTCQPGFRGDGYNCDPISDD-SCA-----IRPDI-----CDVHADCVYEEHLG 856

  Fly   404 DGDRDCPDGDDEHTANCK-NVTCRADQFQCGDRS-CIPGHLTCNGD--KDCADGSDERDCGLSLS 464
            ..:..|..|...:..||: ...|::.: .||:.: |..|...|..|  :|.:|
  Fly   857 KSECQCQAGYTGNGFNCQLAAECQSAE-HCGENAFCDDGVCRCQADFERDVSD------------ 908

  Fly   465 LGINQGGCNATSEFDCGGGQCVPLSKVCDKRKDCPDGEDEPAGKCGINECASKNGGCMHQCIDLK 529
                               :||                  |||:||...|.| |..|..   |..
  Fly   909 -------------------RCV------------------PAGRCGSVFCGS-NAICKW---DSA 932

  Fly   530 VG-HHCECHEGYK------LSPDKRNCQDINECEVPGKCSQICVNEIGGFKCECEAGYMRDP--- 584
            .| .:|:|.:||:      .:....:|..:|.|.:...|..  ..:...::|:|.||:..|.
  Fly   933 EGVQYCDCLDGYQGDALTGCTSKPLSCHVLNNCGIHATCEP--TEDPANYECQCIAGFKGDGYVC 995

  Fly   585 -------KNHTRCKASE------------------GHASLLLARRHD------------IRKIAL 612
                   .|.|.|..:.                  |:.||...|:|.            |.::.|
  Fly   996 IEEQNCLNNPTLCDMNAQCRSTNSGLVCVCNQGFFGNGSLCQERQHQDSDFLIVSQGVMIARVPL 1060

  Fly   613 DHMEMTSIVNSTKAATALDFVFRTGMIFWSDVTTQSIYKAPIDEGNEKTVVLTKSSVTSDGLAVD 677
            :...:..| :..:.|..||.....|.::|.|::|:.|.....| |.:....:|....:.:|:|:|
  Fly  1061 NGRNVRPI-SVAQMAIGLDKDCVEGRVYWGDISTKKIVSTKYD-GTDLRPFITTDIESPEGIAID 1123

  Fly   678 WIYNHVYFTDTHKCTIELTNFEG-SMGKVLVKDSLDIPRSIALDPIEGWMYWSDWG-ASPRIERA 740
            .|...:|:.|:.|.|||:.:.:. |:..|::...|..||.||:||....::||||. .||:||.:
  Fly  1124 VISRRLYWADSAKDTIEVASLDDPSLRAVIINKQLVNPRGIAVDPYREKLFWSDWDRESPKIEMS 1188

  Fly   741 GMDGSHRTTIISY-DVKWPNGITLDLVKKRIYWVDG---KLNVISSANYDGSQRSQVLYSGEYLR 801
            .:||:.|..::.. ||..||.:.:......:.:.|.   |:..|.      .|..|:......|.
  Fly  1189 NLDGTGRELLLGKDDVTLPNSLVVLENSGEVCYADAGTKKVECIE------PQNRQIRTISNELS 1247

  Fly   802 HPFSITTFEDNVYWTDWDKQAVFKANKFTGEDVEPVTAMHMLQHPM--------------VVHVY 852
            :||.||...|..|||||           |.:.||.|.::...|.|:              ||..:
  Fly  1248 YPFGITFTHDQFYWTDW-----------TTKKVEIVDSLGARQTPIQPPFFGSHKMYGMTVVEQH 1301

  Fly   853 HP-YRQPDGVNHCQSVNGHC--SHLCLPAPRINERSPR-ISCAC---PTGLKLMVDG 902
            .| |:.|     ||..||.|  |.|||    :|.::|. .||.|   .||..::..|
  Fly  1302 CPQYQSP-----CQISNGGCTDSRLCL----VNRQAPSGKSCKCTSASTGCTVLAPG 1349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LpR1	NP_001097934.2	LDLa	135..167	CDD:197566	7/35 (20%)
		LDLa	178..210	CDD:197566	6/31 (19%)
		LDLa	219..254	CDD:238060	10/55 (18%)
		LDLa	259..295	CDD:238060	6/35 (17%)
		LDLa	343..373	CDD:238060	9/43 (21%)
		LDLa	383..415	CDD:197566	5/31 (16%)
		Ldl_recept_a	423..459	CDD:278486	9/38 (24%)
		LDLa	476..504	CDD:197566	2/27 (7%)
		FXa_inhibition	514..549	CDD:291342	10/41 (24%)
		EGF_CA	551..581	CDD:214542	7/29 (24%)
		LY	662..702	CDD:214531	11/40 (28%)
		LY	704..747	CDD:214531	18/43 (42%)
		LY	749..790	CDD:214531	7/44 (16%)
		FXa_inhibition	864..905	CDD:291342	17/45 (38%)
Ndg	NP_610575.1	NIDO	108..262	CDD:214712
		EGF_3	285..320	CDD:372403
		G2F	322..549	CDD:214774	9/43 (21%)
		EGF_CA	591..627	CDD:311536	8/42 (19%)
		EGF_3	797..828	CDD:372403	5/33 (15%)
		EGF_3	836..873	CDD:372403	8/46 (17%)
		EGF_3	963..995	CDD:372403	8/33 (24%)
		EGF_3	1001..1036	CDD:372403	5/34 (15%)
		NHL	1059..>1275	CDD:302697	67/234 (29%)
		NHL repeat	1067..1103	CDD:271320	10/37 (27%)
		Ldl_recept_b	1084..1123	CDD:393440	10/39 (26%)
		LY	1107..1145	CDD:214531	11/37 (30%)
		NHL repeat	1117..1154	CDD:271320	12/36 (33%)
		LY	1152..1195	CDD:214531	18/42 (43%)
		NHL repeat	1161..1198	CDD:271320	17/36 (47%)
		NHL repeat	1204..1245	CDD:271320	8/46 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461698
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840