Protein Alignment LpR1 and Lrp1b

DIOPT Version :10

• Sequence 1: NP_001097934.2
• Gene: LpR1 / 2768687
• FlyBaseID: FBgn0066101
• Length: 1076
• Species: Drosophila melanogaster
• Sequence 2: XP_038962031.2
• Gene: Lrp1b / 311926
• RGDID: 1306160
• Length: 4668
• Species: Rattus norvegicus
• Alignment Length: 809
• Identity: 313/809 - (38%)
• Similarity: 436/809 - (53%)
• Gaps: 73/809 - (9%)

  Fly   144 HSGDC------IPIRFVCDGDADCKDHS--DEQIKECKF-----IEATCSSDQFRCGNGNCIPNK 195
            ::|.|      ||...||    .|.|:.  ||....|.|     |...|...:|||.|.:||..:
  Rat   832 NNGGCGTLCLAIPGGRVC----ACADNQLLDENGTTCTFNPEEIIFHICKPGEFRCKNKHCIQAR 892

  Fly   196 WRCDQESDCADGSDEANELCMN-ACPNNEFKCQTVDQCIPRSWLCDGSNDCRDKSDEAH--CRAR 257
            |:||.:.||.|||||.:..|.| :||.::||||. ::|||:.|||||:|||....||::  |.||
  Rat   893 WKCDGDDDCLDGSDEDSVTCFNHSCPEDQFKCQN-NRCIPKRWLCDGANDCGSNEDESNQTCTAR 956

  Fly   258 TCSPDEYACKSGEGQCVPLAWMCDQSKDCSDGSDE-HNCN-QTCR-ADEFTCGNGRCIQKRWKCD 319
            ||..|:::|  |.|:|:|.||:||:..||.|.:|| .:|. .||. ..:|.|.:||||..:|.||
  Rat   957 TCQADQFSC--GNGRCIPTAWVCDREDDCGDQTDEVTSCEFPTCEPLTQFLCKSGRCISNKWHCD 1019

  Fly   320 HDDDCGDGSDEKECPVVPCDSVAEHTCTNGACIAKRWVCDGDPDCSDGSDER--SCA-NVTKTTT 381
            .||||||.|||..|.....|.  :..|.:|.||...|.||||.||.|.|||.  :|. ...::..
  Rat  1020 TDDDCGDRSDEVGCVHSCLDD--QFRCASGRCIPGHWACDGDNDCGDFSDETHVNCTREEARSPV 1082

  Fly   382 PCLSHEYQCKDRITCLHHSWLCDGDRDCPDGDDEHTAN-----CKNVTCRADQFQCGDRS-CIPG 440
            .|:.:|:||.....|:...|.|||::||.||.||...|     |.:.|    :|.|.... ||..
  Rat  1083 GCIGNEFQCHPDGNCIPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKT----KFSCKSTGRCINN 1143

  Fly   441 HLTCNGDKDCADGSDERDCGLSLSLGINQGGC-NATSEFDCGGGQCVPLSKVCDKRKDCPDGEDE 504
            ...|:||.||.|.|||.||. |...|..:..| |.||       .|:...|:|:.|||||||.||
  Rat  1144 AWVCDGDVDCEDQSDEEDCD-SFLCGPPKYPCANDTS-------VCLQPEKLCNGRKDCPDGSDE 1200

  Fly   505 PAGKCGINECASKNGGCMHQC-IDLKVGHHCECHEGYKLSPDKRNCQDINECEVPGKCSQICVNE 568
             ...|  :||:..||||.:.| :....|..|.|.||::|..|.|.|:.::.|....||||:|...
  Rat  1201 -GDLC--DECSLNNGGCSNHCSVVPGKGIVCSCPEGHQLKKDNRTCEIVDYCSSHLKCSQVCEQH 1262

  Fly   569 IGGFKCECEAGYMRDPKNHTRCKASEGHASLLLARRHDIRKIALDHMEMTSIVNSTKAATALDFV 633
            ....||.|..|:..|....:........|.::.:.||:||:|.|...:.:.:|...:...||||.
  Rat  1263 KHMVKCSCYEGWALDTDGESCISVDSFEAFIIFSIRHEIRRIDLHKGDYSLLVPGLRNTIALDFH 1327

  Fly   634 FRTGMIFWSDVTTQSIYKAPIDEGNEKT---VVLTKSSVTSDGLAVDWIYNHVYFTDTHKCTIEL 695
            |...:::|:||....||:..:.|....:   ||:.....|.:||.||||..::|:.|::...||:
  Rat  1328 FNQSLLYWTDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEV 1392

  Fly   696 TNFEGSMGKVLVKDSLDIPRSIALDPIEGWMYWSDWGAS-PRIERAGMDGSHRTTIISYDVK--- 756
            :..:||:...|:..:::.||:|||||..|.::|:||.|: ||||.|.|.|:.|.||.. |:|
  Rat  1393 SKLDGSLRATLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYK-DMKTGA 1456

  Fly   757 WPNGITLDLVKKRIYWVDGKLNVISSANYDGSQRSQVLYSGEYLRHPFSITTFEDNVYWTDWDKQ 821
            ||||:|:|..::||.|.|.:.:.|.||.|||:...:::...|||.|||:::.:...||||||...
  Rat  1457 WPNGLTVDHFERRIVWTDARSDAIYSAFYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTN 1521

  Fly   822 AVFKANKFTGEDVEPVTAMHMLQHPMVVHVYHPYRQPDGVNHCQSVNGH--CSHLCLPAPRIN-E 883
            .:.||||:||::|..:  ......|..:.:|||.|||...|.|.:..|.  ||||||    || .
  Rat  1522 TLAKANKWTGQNVSVI--QKTSAQPFDLQIYHPSRQPQAPNPCAANEGRGPCSHLCL----INHN 1580

  Fly   884 RSPRISCACPTGLKLMVDGLMCVEDPLYL 912
            ||  .:||||..:||..|...|.|...:|
  Rat  1581 RS--AACACPHLMKLSSDKKTCYEMKKFL 1607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LpR1	NP_001097934.2	LDLa	135..167	CDD:197566	8/30 (27%)
		LDLa	178..210	CDD:197566	15/31 (48%)
		LDLa	219..254	CDD:238060	19/36 (53%)
		LDLa	259..295	CDD:238060	16/36 (44%)
		LDLa	343..373	CDD:238060	15/31 (48%)
		LDLa	383..415	CDD:197566	13/31 (42%)
		Ldl_recept_a	423..459	CDD:395011	14/36 (39%)
		LDLa	476..504	CDD:197566	11/27 (41%)
		FXa_inhibition	514..549	CDD:464251	14/35 (40%)
		EGF_CA	551..581	CDD:214542	10/29 (34%)
		LY	662..702	CDD:214531	14/39 (36%)
		LY	704..747	CDD:214531	20/43 (47%)
		LY	749..790	CDD:214531	20/43 (47%)
		Ldl_recept_b	769..815	CDD:459654	17/45 (38%)
		FXa_inhibition	864..905	CDD:464251	19/43 (44%)
Lrp1b	XP_038962031.2	None