DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LpR1 and Lrp10

DIOPT Version :9

Sequence 1:	NP_001097934.2	Gene:	LpR1 / 2768687	FlyBaseID:	FBgn0066101	Length:	1076	Species:	Drosophila melanogaster
Sequence 2:	NP_001382489.1	Gene:	Lrp10 / 305880	RGDID:	1310471	Length:	712	Species:	Rattus norvegicus

Alignment Length:	438	Identity:	106/438 - (24%)
Similarity:	145/438 - (33%)	Gaps:	136/438 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 KSTTSSKSPVTFGNLGEKRRAE----QLFRCACANFNLLLLTLMLGFGKCCTATPTPLNTPSTNT 80
            :.:.||.:..|:..||.|.:..    |....||.:.:|:|.:.:......|.|...||..|..|.
  Rat    50 RDSRSSPANCTWVILGSKEQTVTVRFQKLHLACGSEHLILHSPLQPPVSLCEAPAGPLQLPGGNV 114

  Fly    81 PTSAVSPHNPQTLDESGSLSKVIDGKAFINMGFKFLNVSGKIGTPLGIGQSLEAK-----CDEKQ 140
            ..         |...:|:.:                        |:|.|..|...     |.:::
  Rat   115 TI---------TYSYAGARA------------------------PMGQGFLLTYSQDWLLCLQEE 146

  Fly   141 FQCHSGDCIPIRFVCDGDADCKDHSDEQIKECKFIEATCSSDQFRCGNGNCIPNK---------- 195
            |||.:..|||....|||...|.|.||         ||.|.||.|    .|.:|..
  Rat   147 FQCLNHRCIPAAQRCDGIDACGDGSD---------EAGCRSDPF----PNPVPAPTPPCNLTLED 198

  Fly   196 -----------------------WRCDQES----------------------DCADGSDEANELC 215
                                   |..|...                      |.| |..|...|.
  Rat   199 FYGVFSSPGYSHLASVSHPQSCLWLLDPHDGRRLAVRFTALDLSYGDAVHVYDGA-GPPETPRLL 262

  Fly   216 MNACPNNEFKCQTVD----QCIPRSWLCDGSNDCRDKSDEAHCRARTCSPDEYACKSGEG----- 271
            .:....:..|..||:    |.:........||. |..:...|.|. .|.|.:..|..|.|
  Rat   263 RSLTHFSNGKAVTVETLSGQAVVSYHTVAWSNG-RGFNATYHVRG-YCLPWDRPCGLGSGLGASE 325

  Fly   272 ----QCVPLAWMCDQSKDCSDGSDEHNCNQTCRADEFTCGNG------RCIQKRWKCDHDDDCGD 326
                :|...|..||.|.||:||:||..| ..|....:.||..      .|.....:|::...|.|
  Rat   326 NLGERCYSEAQRCDGSWDCADGTDEEGC-PGCPPGHYPCGAAGTPGATACYLPADRCNYQTFCAD 389

  Fly   327 GSDEKECPVVPCDSVAEHTCTNGACIAKRWVCDGDPDCSDGSDERSCA 374
            |:||:.|.  .|.. ....|.:..|:.:.|||||.|||:|||||..|:
  Rat   390 GADERRCR--HCQP-GNFRCRDEKCVYETWVCDGQPDCTDGSDEWDCS 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LpR1	NP_001097934.2	LDLa	135..167	CDD:197566	13/36 (36%)
		LDLa	178..210	CDD:197566	11/86 (13%)
		LDLa	219..254	CDD:238060	7/38 (18%)
		LDLa	259..295	CDD:238060	16/44 (36%)
		LDLa	343..373	CDD:238060	15/29 (52%)
		LDLa	383..415	CDD:197566
		Ldl_recept_a	423..459	CDD:278486
		LDLa	476..504	CDD:197566
		FXa_inhibition	514..549	CDD:291342
		EGF_CA	551..581	CDD:214542
		LY	662..702	CDD:214531
		LY	704..747	CDD:214531
		LY	749..790	CDD:214531
		FXa_inhibition	864..905	CDD:291342
Lrp10	NP_001382489.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000