DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LpR1 and Lrp1

DIOPT Version :10

Sequence 1:NP_001097934.2 Gene:LpR1 / 2768687 FlyBaseID:FBgn0066101 Length:1076 Species:Drosophila melanogaster
Sequence 2:XP_008763615.1 Gene:Lrp1 / 299858 RGDID:1307535 Length:4562 Species:Rattus norvegicus


Alignment Length:844 Identity:319/844 - (37%)
Similarity:452/844 - (53%) Gaps:93/844 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   130 QSLEAKC-DEKQFQCHSGDCIPIRFVCDGDADCKDHSDEQ-----IKECKFI------------- 175
            :::.:.| .:.:|:|.:|:||.....|||.:.|||.|||:     .:.||..             
  Rat  2536 RAMNSSCRAQDEFECANGECISFSLTCDGVSHCKDKSDEKPSYCNSRRCKKTFRQCNNGRCVSNM 2600

  Fly   176 -------------------EATCSSDQFRCGNGNCIPNKWRCDQESDCADGSDEANELCMNACPN 221
                               :..|...:|||.:|:||.|..||:|..||.|.|||.|  |.....:
  Rat  2601 LWCNGVDDCGDGSDEIPCNKTACGVGEFRCRDGSCIGNSSRCNQFVDCEDASDEMN--CSATDCS 2663

  Fly   222 NEFK----------CQTVDQCIPRSWLCDGSNDCRDKSDEAHC----RARTCSPDEYACKSGEGQ 272
            :.|:          |:....|...||:|||:|||.|.|||..|    |.| |..:.:||.|  |:
  Rat  2664 SYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPR-CPLNYFACPS--GR 2725

  Fly   273 CVPLAWMCDQSKDCSDGSDEHNCNQTCRADEFTCGNGRCIQKRWKCDHDDDCGDGSDE-KECPVV 336
            |:|::|.||:..||.:|.||.:||:.|...:|.|.|.|||.|:|.||..||||||||| ..|...
  Rat  2726 CIPMSWTCDKEDDCENGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEGK 2790

  Fly   337 PCDSVAEHTCTNGACIAKRWVCDGDPDCSDGSDERSCANVTKTTTPCLSHEYQCKDRITCLHHSW 401
            .|...:........|:.:||:||||.||:||:||...|.....:| |...|:.|::|: |:...:
  Rat  2791 TCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESISAGCLYNST-CDDREFMCQNRL-CIPKHF 2853

  Fly   402 LCDGDRDCPDGDDEHTANCKNVTCRADQFQCGDRSCIPG-HLTCNGDKDCADGSDER----DCGL 461
            :||.||||.||.|| :..|:..||..::|:|.:..|:.. ...|:|:.||.|.|||.    .|..
  Rat  2854 VCDHDRDCADGSDE-SPECEYPTCGPNEFRCANGRCLSSRQWECDGENDCHDHSDEAPKNPHCTS 2917

  Fly   462 SLSLGINQGGCNATSEFDCGGGQCVPLSKVCDKRKDCPDGEDEPAGKCGINECAS-KNGGCMHQC 525
            .      :..|||:|:|.|..|:||..:.:|:.:.||.||.||..  |.:|||.| |..||...|
  Rat  2918 P------EHKCNASSQFLCSSGRCVAEALLCNGQDDCGDGSDERG--CHVNECLSRKLSGCSQDC 2974

  Fly   526 IDLKVGHHCECHEGYKLSPDKRNCQDINECEVPGKCSQICVNEIGGFKCECEAGYM---RDPKNH 587
            .|||:|..|.|..|::|..|.|.|.|::||.....|||:|:|..|.:||.|..||.   .||.: 
  Rat  2975 EDLKIGFKCRCRPGFRLKDDGRTCADVDECSTTFPCSQLCINTHGSYKCLCVEGYAPRGGDPHS- 3038

  Fly   588 TRCKA-SEGHASLLLARRHDIRKIALDHMEMTSIVNSTKAATALDFVFRTGMIFWSDVTTQSIYK 651
              ||| ::....|:.|.|:.:||:.||....|.:......|.||||.:|..||:|:|||||....
  Rat  3039 --CKAVTDEEPFLIFANRYYLRKLNLDGSNYTLLKQGLNNAVALDFDYRGQMIYWTDVTTQGSMI 3101

  Fly   652 APIDEGNEKTVVLTKSSVTS-DGLAVDWIYNHVYFTDTHKCTIELTNFEGSMGKVLVKDSLDIPR 715
            ..:........||.::.::: |||||||:..::|:.|..:.|||::...|:...|||...|..||
  Rat  3102 RRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPR 3166

  Fly   716 SIALDPIEGWMYWSDWGASPRIERAGMDGSHRTTIISYDVKWPNGITLDLVKKRIYWVDGKLNVI 780
            ::.:|...|::||:|||....|.|.|||||.|:.|:...:.||||:|:|.|.:||||.|.:.:.|
  Rat  3167 ALVVDVQNGYLYWTDWGDHSLIGRIGMDGSGRSIIVDTKITWPNGLTVDYVTERIYWADAREDYI 3231

  Fly   781 SSANYDGSQRSQVLYSGEYLRHPFSITTFEDNVYWTDWDKQAVFKANKFTGEDVEPVTAMHMLQH 845
            ..|:.|||.|..||  .:.:.|.|::|.|||.||||||:.:::.:|:|.||  ......:..|..
  Rat  3232 EFASLDGSNRHVVL--SQDIPHIFALTLFEDYVYWTDWETKSINRAHKTTG--ANKTLLISTLHR 3292

  Fly   846 PMVVHVYHPYRQPDGVNH-CQSVNGHCSHLCLPAPRINERSPRISCACPTGLKLMVDGLMCVED 908
            ||.:||:|..||||..|| |:..||.||:|||.:|....:     |||||...|..||..||.:
  Rat  3293 PMDLHVFHALRQPDVPNHPCKVNNGGCSNLCLLSPGGGHK-----CACPTNFYLGGDGRTCVSN 3351

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LpR1NP_001097934.2 LDLa 135..167 CDD:197566 13/32 (41%)
LDLa 178..210 CDD:197566 15/31 (48%)
LDLa 219..254 CDD:238060 15/44 (34%)
LDLa 259..295 CDD:238060 15/35 (43%)
LDLa 343..373 CDD:238060 13/29 (45%)
LDLa 383..415 CDD:197566 13/31 (42%)
Ldl_recept_a 423..459 CDD:395011 13/40 (33%)
LDLa 476..504 CDD:197566 11/27 (41%)
FXa_inhibition 514..549 CDD:464251 16/35 (46%)
EGF_CA 551..581 CDD:214542 13/29 (45%)
LY 662..702 CDD:214531 15/40 (38%)
LY 704..747 CDD:214531 20/42 (48%)
LY 749..790 CDD:214531 18/40 (45%)
Ldl_recept_b 769..815 CDD:459654 20/45 (44%)
FXa_inhibition 864..905 CDD:464251 17/40 (43%)
Lrp1XP_008763615.1 LDLa 27..60 CDD:197566
LDLa 72..105 CDD:197566
FXa_inhibition 120..149 CDD:464251
FXa_inhibition 159..189 CDD:464251
LY 276..315 CDD:214531
LY 317..359 CDD:214531
LY 362..402 CDD:214531
FXa_inhibition 487..520 CDD:464251
LY 552..594 CDD:214531
LY 595..634 CDD:214531
LY 641..690 CDD:214531
LY <701..734 CDD:214531
FXa_inhibition 808..843 CDD:464251
LDLa 854..886 CDD:197566
LDLa 896..929 CDD:238060
LDLa 936..968 CDD:197566
LDLa 979..1012 CDD:238060
LDLa 1033..1066 CDD:238060
LDLa 1080..1115 CDD:238060
LDLa 1122..1158 CDD:238060
LDLa 1163..1196 CDD:238060
FXa_inhibition 1203..1239 CDD:464251
Vgb 1328..>1521 CDD:443399
LY 1354..1394 CDD:214531
LY 1398..1441 CDD:214531
LY 1631..1667 CDD:214531
LY 1668..1711 CDD:214531
LY 1715..1752 CDD:214531
LY 1752..1793 CDD:214531
FXa_inhibition 1868..1904 CDD:464251
LY 1934..1974 CDD:214531
LY 1977..2017 CDD:214531
LY 2018..2061 CDD:214531
LY 2063..2105 CDD:214531
FXa_inhibition 2177..2212 CDD:464251
LY 2293..2333 CDD:214531
Ldl_recept_b 2362..2404 CDD:459654
LY 2388..2429 CDD:214531
FXa_inhibition 2500..2532 CDD:464251
LDLa 2545..2575 CDD:238060 13/29 (45%)
LDLa 2584..2618 CDD:238060 2/33 (6%)
LDLa 2623..2657 CDD:238060 18/35 (51%)
LDLa <2684..2706 CDD:238060 13/21 (62%)
LDLa 2714..2748 CDD:238060 15/35 (43%)
LDLa 2752..2783 CDD:197566 18/30 (60%)
LDLa 2791..2824 CDD:197566 12/32 (38%)
LDLa 2835..2867 CDD:197566 14/33 (42%)
LDLa 2875..2908 CDD:197566 11/32 (34%)
LDLa 2925..2957 CDD:238060 13/33 (39%)
cEGF 2982..3003 CDD:463661 8/20 (40%)
EGF_CA 3000..>3029 CDD:214542 12/28 (43%)
LY 3067..3111 CDD:214531 15/43 (35%)
LY 3112..3154 CDD:214531 15/41 (37%)
LY 3156..3198 CDD:214531 20/41 (49%)
LY 3200..3241 CDD:214531 18/40 (45%)
LY 3242..3282 CDD:214531 18/43 (42%)
FXa_inhibition 3312..3348 CDD:464251 17/40 (43%)
LDLa 3352..3383 CDD:238060 319/844 (38%)
LDLa 3392..3426 CDD:238060
LDLa 3431..3466 CDD:238060
LDLa 3470..3503 CDD:197566
LDLa 3511..3544 CDD:197566
LDLa 3554..3588 CDD:238060
LDLa 3593..3627 CDD:238060
LDLa 3631..3665 CDD:238060
LDLa 3671..3703 CDD:197566
LDLa 3713..3749 CDD:238060
LDLa 3764..3794 CDD:238060
YncE 3880..4082 CDD:442618
LY 3973..4010 CDD:214531
Ldl_recept_b 4031..4072 CDD:459654
LY 4055..4096 CDD:214531
Blue background indicates that the domain is not in the aligned region.

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