DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LpR1 and Vldlr

DIOPT Version :9

Sequence 1:	NP_001097934.2	Gene:	LpR1 / 2768687	FlyBaseID:	FBgn0066101	Length:	1076	Species:	Drosophila melanogaster
Sequence 2:	NP_037287.2	Gene:	Vldlr / 25696	RGDID:	3963	Length:	873	Species:	Rattus norvegicus

Alignment Length:	950	Identity:	369/950 - (38%)
Similarity:	508/950 - (53%)	Gaps:	119/950 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 EAKCDEKQFQCHSGDCIPIRFVCDGDADCKDHSDEQIKECKFIEATCSSDQFRCGNGNCIPNKWR 197
            :||||..||||.:|.||.:.:.||||.||.|.|||  |.|  ::.||:...|.|.||.|:||:|:
  Rat    30 KAKCDSSQFQCTNGRCITLLWKCDGDEDCTDGSDE--KNC--VKKTCAESDFVCKNGQCVPNRWQ 90

  Fly   198 CDQESDCADGSDEANELCMNACPNNEFKCQTVDQCIPRSWLCDGSNDCRDKSDEAHCRARTCSPD 262
            ||.:.||.|||||:.|                                       .|..|||..:
  Rat    91 CDGDPDCEDGSDESPE---------------------------------------QCHMRTCRIN 116

  Fly   263 EYACKSGEGQCVPLAWMCDQSKDCSDGSDEHNC-NQTCRADEFTCGNGRCIQKRWKCDHDDDCGD 326
            |.:|.:...||:|.:|.||...||.:|.||.|| |.||.||||||.:|||:.:.:.|:..|||.|
  Rat   117 EISCGARSTQCIPESWRCDGENDCDNGEDEENCGNITCSADEFTCSSGRCVSRNFVCNGQDDCDD 181

  Fly   327 GSDEKECPVVPCDSVAEHTCTNGACIAKRWVCDGDPDCSDGSDE--RSCANVTKTTTPCLSHEYQ 389
            ||||.:|....| ...|..|:..:||...||||.|.||||.|||  ..|.......|.|.:.|.|
  Rat   182 GSDELDCAPPTC-GAHEFQCSTSSCIPLSWVCDDDADCSDQSDESLEQCGRQPVIHTKCPTSEIQ 245

  Fly   390 CKDRITCLHHSWLCDGDRDCPDGDDEHTANCKNVTCRADQFQCGDRSCIPGHLTCNGDKDCADGS 454
            |... .|:|..|.||||.||.||.||  .||.:.|||.|||:|.|.|||.|...|||.:||.|||
  Rat   246 CGSG-ECIHKKWRCDGDPDCKDGSDE--VNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGS 307

  Fly   455 DERDCGLSLSLGINQGGCNATSEFDCGGGQCVPLSKVCDKRKDCPDGEDEPAGKCGINECASKNG 519
            ||.:|     ..:||  |....:|.|..|:|:.::||||:.:||.|..|||..:|.||||...||
  Rat   308 DEVNC-----KNVNQ--CLGPGKFKCRSGECIDITKVCDQEQDCRDWSDEPLKECHINECLVNNG 365

  Fly   520 GCMHQCIDLKVGHHCECHEGYKLSPDKRNCQDINECEVPGKCSQICVNEIGGFKCECEAGYMRDP 584
            ||.|.|.||.:|:.|:|..|::|. |::.|.||:||:.||.|||||:|..||:||||..||..|.
  Rat   366 GCSHICKDLVIGYECDCAAGFELI-DRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDL 429

  Fly   585 KNHTRCKASEGHASLLLARRHDIRKIALDHMEMTSIVNSTKAATALDFVFRTGMIFWSDVTTQSI 649
            .... |||.....||:...|.|||||.|:..|...:|...:...|||.......:||:|::.::|
  Rat   430 ATGV-CKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAI 493

  Fly   650 YKAPIDEGNEKTVVLTKSSVTSDGLAVDWIYNHVYFTDTHKCTIELTNFEGSMGKVLVKDSLDIP 714
            :.|.||:...:...:..:......:||||:|..:|:||....||.:...:|:..|.|....|..|
  Rat   494 FSASIDDKVGRHFKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREP 558

  Fly   715 RSIALDPIEGWMYWSDWGASPRIERAGMDGSHRTTIISYDVKWPNGITLDLVKKRIYWVDGKLNV 779
            .|||:||:.|::||||||...:||:|||:|..|..:::.|::|||||||||||.|:||:|.||::
  Rat   559 ASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTEDIQWPNGITLDLVKSRLYWLDSKLHM 623

  Fly   780 ISSANYDGSQRSQVLYSGEYLRHPFSITTFEDNVYWTDWDKQAVFKANKFTGEDVEPVTAMHMLQ 844
            :||.:.:|..|..||.|.|:|.||.::|.|||.|||.|.:.:||:.||||||.::  .|.::.|.
  Rat   624 LSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSEL--ATLVNNLN 686

  Fly   845 HPMVVHVYHPYRQPDGVNHCQS--VNGHCSHLCLPAPRINERSPRISCACPTGLKLMVDGLMCVE 907
            ....:.:||...||.|.|.|:.  .||.|.:||||||:||:.||:.:|:||.|..|..:|..|
  Rat   687 DAQDIIIYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPNGYNLEENGREC-- 749

  Fly   908 DPLYLPPVTRPPRARKTKPRPKSPRRRLPTGVQVGHADIRIEINDDLQLSTRLP--LLPTTFVAD 970
                 ...:.|....:||.                     :...|.|:.|..:|  :..||.|::
  Rat   750 -----QSTSTPVTYSETKD---------------------VNTTDILRTSGLVPGGINVTTAVSE 788

  Fly   971 QRPVKNHTQIEKTTTPSEQPDSGFIALVVIASLSGFAVLLSVLLLIGYRYCSKRRINSMNFENPI 1035
            .......|.......|        :.|:|:|::.|:.:         :|....:.:.||||:||:
  Rat   789 VSVPPKGTSAAWAILP--------LLLLVMAAVGGYLM---------WRNWQHKNMKSMNFDNPV 836

  Fly  1036 YRKTTTTEDHFSLRKNLPARIYDHTSVMDEEYSPVIGISS 1075
            |.|||        .::|...|..|::.:...| |.|.:.|
  Rat   837 YLKTT--------EEDLSIDIGRHSASVGHTY-PAISVVS 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LpR1	NP_001097934.2	LDLa	135..167	CDD:197566	18/31 (58%)
		LDLa	178..210	CDD:197566	17/31 (55%)
		LDLa	219..254	CDD:238060	0/34 (0%)
		LDLa	259..295	CDD:238060	14/35 (40%)
		LDLa	343..373	CDD:238060	16/31 (52%)
		LDLa	383..415	CDD:197566	15/31 (48%)
		Ldl_recept_a	423..459	CDD:278486	22/35 (63%)
		LDLa	476..504	CDD:197566	11/27 (41%)
		FXa_inhibition	514..549	CDD:291342	15/34 (44%)
		EGF_CA	551..581	CDD:214542	19/29 (66%)
		LY	662..702	CDD:214531	11/39 (28%)
		LY	704..747	CDD:214531	22/42 (52%)
		LY	749..790	CDD:214531	21/40 (53%)
		FXa_inhibition	864..905	CDD:291342	20/42 (48%)
Vldlr	NP_037287.2	LDLa	33..67	CDD:238060	20/35 (57%)
		LDLa	71..103	CDD:197566	17/31 (55%)
		Ldl_recept_a	111..149	CDD:395011	16/37 (43%)
		Ldl_recept_a	153..188	CDD:395011	20/34 (59%)
		LDLa	192..224	CDD:197566	15/32 (47%)
		Ldl_recept_a	237..273	CDD:395011	18/38 (47%)
		Ldl_recept_a	276..312	CDD:395011	22/35 (63%)
		Ldl_recept_a	320..350	CDD:395011	11/29 (38%)
		FXa_inhibition	360..394	CDD:405372	15/34 (44%)
		EGF_CA	396..426	CDD:214542	19/29 (66%)
		LDL-receptor class B 1	439..480		14/40 (35%)
		LY	461..499	CDD:214531	9/37 (24%)
		LDL-receptor class B 2	481..524		11/42 (26%)
		Ldl_recept_b	481..521	CDD:395012	8/39 (21%)
		LY	508..547	CDD:214531	11/38 (29%)
		LDL-receptor class B 3	525..567		15/41 (37%)
		LDL-receptor class B 4	568..611		24/42 (57%)
		Ldl_recept_b	568..608	CDD:395012	21/39 (54%)
		LY	592..634	CDD:214531	21/41 (51%)
		LDL-receptor class B 5	612..654		18/41 (44%)
		LDL-receptor class B 6	655..697		17/43 (40%)
		Ldl_recept_b	655..694	CDD:395012	15/40 (38%)
		FXa_inhibition	706..749	CDD:405372	20/42 (48%)
		Clustered O-linked oligosaccharides	751..790		10/59 (17%)
		Endocytosis signal. /evidence=ECO:0000255	832..837		3/4 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	55	1.000	Domainoid score	I10838
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H443
Inparanoid	1	1.050	710	1.000	Inparanoid score	I619
OMA	1	1.010	-	-		QHG49125
OrthoDB	1	1.010	-	-		D179614at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9029
orthoMCL	1	0.900	-	-		OOG6_103130
Panther	1	1.100	-	-	O	PTHR24270
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1052
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.980