Protein Alignment LpR1 and Lrp4

DIOPT Version :10

• Sequence 1: NP_001097934.2
• Gene: LpR1 / 2768687
• FlyBaseID: FBgn0066101
• Length: 1076
• Species: Drosophila melanogaster
• Sequence 2: NP_766256.3
• Gene: Lrp4 / 228357
• MGIID: 2442252
• Length: 1905
• Species: Mus musculus
• Alignment Length: 786
• Identity: 335/786 - (42%)
• Similarity: 425/786 - (54%)
• Gaps: 89/786 - (11%)

  Fly   127 GIGQSLEAKCDEKQFQCHSG-----DCIPIRFVCDGDADCKDHSDEQIKECKFIEATCSSDQFRC 186
            ||..|||..|....|.|...     .|||.::.||||.||.|||||.  .|..  .|||...|.|
Mouse    18 GIASSLECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDED--GCTL--PTCSPLDFHC 78

  Fly   187 GNGNCIPNKWRCDQESDCADGSDEANELC-MNACPNNEFKCQTVDQCIPRSWLCDGSNDCRDKSD 250
            .||.||...|.||.::||.|.|||.:  | ...|..:||.||. ..||...|.|||.|||.|.||
Mouse    79 DNGKCIRRSWVCDGDNDCEDDSDEQD--CPPRECEEDEFPCQN-GYCIRSLWHCDGDNDCGDNSD 140

  Fly   251 EAHCRARTCSPDEYACKSGEGQCVPLAWMCDQSKDCSDGSDEHNC-----NQTCRADEFTCGNGR 310
            | .|..|.||..|:.|  .:|.|:...|.||...||.|||||.:|     :..|..:||.|..||
Mouse   141 E-QCDMRKCSDKEFRC--SDGSCIAEHWYCDGDTDCKDGSDEESCPSAVPSPPCNLEEFQCAYGR 202

  Fly   311 CIQKRWKCDHDDDCGDGSDEKECPV-VPCDSVAEHTCTNGACIAKRWVCDGDPDCSDGSDERSCA 374
            ||...:.||.||||||.|||.:|.. .||.| .|..|.:|.||...|.||||.||.|.||||:|
Mouse   203 CILDIYHCDGDDDCGDWSDESDCSSHQPCRS-GEFMCDSGLCINSGWRCDGDADCDDQSDERNC- 265

  Fly   375 NVTKTTTPCLSHEYQCKDRITCLHHSWLCDGDRDCPDGDDEHTANCKNV---TCRADQFQCGDRS 436
                ||:.|.:.:::|:.. .|:..||.|||:.||.|..||.  ||:|.   .|.:|||.|.:..
Mouse   266 ----TTSMCTAEQFRCRSG-RCVRLSWRCDGEDDCADNSDEE--NCENTGSPQCASDQFLCWNGR 323

  Fly   437 CIPGHLTCNGDKDCADGSDERDCGLSLSLGINQGGCNATSEFDCGGGQCVPLSKVCDKRKDCPDG 501
            ||.....|||..||.|.|||..          |..|...:                        |
Mouse   324 CIGQRKLCNGINDCGDSSDESP----------QQNCRPRT------------------------G 354

  Fly   502 EDEPAGKCGINECASKNGGCMHQCIDLKVGHHCECHEGYKLSPDKRNCQDINECEVPGKCSQICV 566
            |:    .|.:|     ||||..:|..::....|.||.||:|:.|.|.|||:|||...|.|||.|.
Mouse   355 EE----NCNVN-----NGGCAQKCQMVRGAVQCTCHTGYRLTEDGRTCQDVNECAEEGYCSQGCT 410

  Fly   567 NEIGGFKCECEAGYMRDPKNHTRCKASEGHASLLLARRHDIRKIALDHMEMTSIVNSTKAATALD 631
            |..|.|:|.|||||...|...: |||......||.|.|.|||::.....|.|.::|:.:.|.|||
Mouse   411 NTEGAFQCWCEAGYELRPDRRS-CKALGPEPVLLFANRIDIRQVLPHRSEYTLLLNNLENAIALD 474

  Fly   632 FVFRTGMIFWSDVTTQSIYKAPIDEGNEKTVVLTKSSVTSDGLAVDWIYNHVYFTDTHKCTIELT 696
            |..|..::||||||...|.:|.::..|.:.||.| ...:..||||||:::.:|:||:....||:.
Mouse   475 FHHRRELVFWSDVTLDRILRANLNGSNVEEVVST-GLESPGGLAVDWVHDKLYWTDSGTSRIEVA 538

  Fly   697 NFEGSMGKVLVKDSLDIPRSIALDPIEGWMYWSDWGASPRIERAGMDGSHRTTIISYDVKWPNGI 761
            |.:|:..|||:..||:.||:|||.|:||.:||:|||.:||||.:.||||.|..|....:.||||:
Mouse   539 NLDGAHRKVLLWQSLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRIIADTHLFWPNGL 603

  Fly   762 TLDLVKKRIYWVDGKLNVISSANYDGSQRSQVLYSGEYLRHPFSITTFEDNVYWTDWDKQAVFKA 826
            |:|...:|:||||.|.:||..||.|||.|..|:..|  |.|||:||.|||::|||||..:::..|
Mouse   604 TIDYAGRRMYWVDAKHHVIERANLDGSHRKAVISQG--LPHPFAITVFEDSLYWTDWHTKSINSA 666

  Fly   827 NKFTGEDVEPVTAMHMLQHPMVVHVYHPYRQPDGVNHCQSVNGHCSHLCLPAPRINERSPRISCA 891
            |||||::.|.:  .:.|..||.:|..||.|||.|.|.|...||.|:|||||:      ....:||
Mouse   667 NKFTGKNQEII--RNKLHFPMDIHTLHPQRQPAGKNRCGDNNGGCTHLCLPS------GQNYTCA 723

  Fly   892 CPTGLK 897
            ||||.:
Mouse   724 CPTGFR 729

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LpR1	NP_001097934.2	LDLa	135..167	CDD:197566	15/36 (42%)
		LDLa	178..210	CDD:197566	16/31 (52%)
		LDLa	219..254	CDD:238060	18/34 (53%)
		LDLa	259..295	CDD:238060	16/35 (46%)
		LDLa	343..373	CDD:238060	17/29 (59%)
		LDLa	383..415	CDD:197566	11/31 (35%)
		Ldl_recept_a	423..459	CDD:395011	16/38 (42%)
		LDLa	476..504	CDD:197566	2/27 (7%)
		FXa_inhibition	514..549	CDD:464251	13/34 (38%)
		EGF_CA	551..581	CDD:214542	17/29 (59%)
		LY	662..702	CDD:214531	16/39 (41%)
		LY	704..747	CDD:214531	26/42 (62%)
		LY	749..790	CDD:214531	20/40 (50%)
		Ldl_recept_b	769..815	CDD:459654	25/45 (56%)
		FXa_inhibition	864..905	CDD:464251	15/34 (44%)
Lrp4	NP_766256.3	LDLa	27..66	CDD:238060	17/40 (43%)
		Ldl_recept_a	70..105	CDD:395011	18/36 (50%)
		LDLa	110..142	CDD:238060	18/33 (55%)
		LDLa	148..182	CDD:238060	16/35 (46%)
		LDLa	231..265	CDD:238060	19/34 (56%)
		LDLa	270..304	CDD:238060	13/36 (36%)
		LDLa	311..343	CDD:197566	14/31 (45%)
		FXa_inhibition	358..393	CDD:464251	15/39 (38%)
		EGF_CA	395..434	CDD:214542	19/39 (49%)
		LY	460..502	CDD:214531	16/41 (39%)
		LDL-receptor class B 1	480..522		18/42 (43%)
		LY	505..545	CDD:214531	16/40 (40%)
		LDL-receptor class B 2	523..565		18/41 (44%)
		LDL-receptor class B 3	566..609		22/42 (52%)
		Ldl_recept_b	566..607	CDD:459654	21/40 (53%)
		LY	590..632	CDD:214531	20/41 (49%)
		LDL-receptor class B 4	610..652		24/43 (56%)
		LY	633..673	CDD:214531	22/41 (54%)
		LDL-receptor class B 5	653..693		17/41 (41%)
		FXa_inhibition	702..>729	CDD:464251	15/32 (47%)
		YncE	749..982	CDD:442618
		LDL-receptor class B 6	785..827
		LY	808..850	CDD:214531
		LDL-receptor class B 7	828..870
		LDL-receptor class B 8	871..914
		Ldl_recept_b	871..912	CDD:459654
		LY	895..937	CDD:214531
		LDL-receptor class B 9	915..956
		LDL-receptor class B 10	957..998
		FXa_inhibition	1006..1043	CDD:464251
		NHL	<1085..1277	CDD:302697
		NHL repeat	1085..1123	CDD:271320
		LDL-receptor class B 11	1093..1135
		NHL repeat	1128..1161	CDD:271320
		LDL-receptor class B 12	1136..1178
		NHL repeat	1166..1203	CDD:271320
		LDL-receptor class B 13	1179..1222
		Ldl_recept_b	1179..1219	CDD:459654
		NHL repeat	1212..1244	CDD:271320
		LDL-receptor class B 14	1223..1263
		NHL repeat	1253..1277	CDD:271320
		LDL-receptor class B 15	1264..1306
		FXa_inhibition	1313..1348	CDD:464251
		Vgb	1359..1583	CDD:443399
		LDL-receptor class B 16	1397..1439
		LDL-receptor class B 17	1440..1482
		LDL-receptor class B 18	1483..1526
		Ldl_recept_b	1483..1524	CDD:459654
		LY	1507..1547	CDD:214531
		LDL-receptor class B 19	1527..1568
		LDL-receptor class B 20	1569..1610
		FXa_inhibition	1617..1648	CDD:464251
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1661..1696
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1852..1905