DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LpR1 and lrx-1

DIOPT Version :9

Sequence 1:	NP_001097934.2	Gene:	LpR1 / 2768687	FlyBaseID:	FBgn0066101	Length:	1076	Species:	Drosophila melanogaster
Sequence 2:	NP_506072.2	Gene:	lrx-1 / 192091	WormBaseID:	WBGene00003075	Length:	368	Species:	Caenorhabditis elegans

Alignment Length:	221	Identity:	80/221 - (36%)
Similarity:	102/221 - (46%)	Gaps:	29/221 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 CDEKQFQCHSGDCIPIRFVCDGDADCKDHSDEQ------IKECK--------FIEATCSSDQFRC 186
            |....|||..|...|:  .|..:....|.|.|.      ||.|.        .|:.||:.::|.|
Worm   153 CSHVFFQCSIGQTFPL--ACMSEDQAFDKSTENCNHKNAIKFCPEYDHVMHCTIKDTCTENEFAC 215

  Fly   187 --GNGNCIPNKWRCDQESDCADGSDEANELCMNACPNNEFKCQTVDQCIPRSWLCDG-SNDCRDK 248
              ...:||....|||...|||||.||.|  | .:|..:||.|...:.|||.:..||| ::||.|.
Worm   216 CAMPQSCIHVSKRCDGHPDCADGEDENN--C-PSCARDEFACVKSEHCIPANKRCDGVADDCEDG 277

  Fly   249 S--DEAHCRARTCSPDEYACKSGEG--QCVPLAWMCDQSKDCSDGSDEHNCNQTCRADEFTCGNG 309
            |  ||..|...|....::.|.:..|  .||.|...||..|||.:|.||.||.|..|.....|.|.
Worm   278 SNLDEIGCSKNTTCIGKFVCGTSRGGVSCVDLDMHCDGKKDCLNGEDEMNCKQEGRQKYLLCENQ 342

  Fly   310 R--CIQKRWKCDHDDDCGDGSDEKEC 333
            :  ..:.:| |:.:.||.||||||.|
Worm   343 KQSVTRLQW-CNGETDCADGSDEKYC 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LpR1	NP_001097934.2	LDLa	135..167	CDD:197566	9/30 (30%)
		LDLa	178..210	CDD:197566	14/33 (42%)
		LDLa	219..254	CDD:238060	16/37 (43%)
		LDLa	259..295	CDD:238060	13/37 (35%)
		LDLa	343..373	CDD:238060
		LDLa	383..415	CDD:197566
		Ldl_recept_a	423..459	CDD:278486
		LDLa	476..504	CDD:197566
		FXa_inhibition	514..549	CDD:291342
		EGF_CA	551..581	CDD:214542
		LY	662..702	CDD:214531
		LY	704..747	CDD:214531
		LY	749..790	CDD:214531
		FXa_inhibition	864..905	CDD:291342
lrx-1	NP_506072.2	LDLa	208..244	CDD:238060	16/37 (43%)
		LDLa	247..285	CDD:238060	16/37 (43%)
		LDLa	293..328	CDD:238060	13/34 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910