Protein Alignment LpR1 and T13C2.6

DIOPT Version :9

• Sequence 1: NP_001097934.2
• Gene: LpR1 / 2768687
• FlyBaseID: FBgn0066101
• Length: 1076
• Species: Drosophila melanogaster
• Sequence 2: NP_872023.2
• Gene: T13C2.6 / 174116
• WormBaseID: WBGene00020481
• Length: 911
• Species: Caenorhabditis elegans
• Alignment Length: 1009
• Identity: 343/1009 - (33%)
• Similarity: 482/1009 - (47%)
• Gaps: 221/1009 - (21%)

  Fly   112 GFKFLNVSG-KIG-TPLGIGQSLEAKCD-EKQFQCHSGDCIPIRFVCDGDADCKDHSDEQIKECK 173
            ||..::::. .:| .|:|   :...||| ...|||..|.|||:.:.||||.||::..||  |.|.
 Worm     9 GFLLISMATISVGLQPMG---APTRKCDATNSFQCQDGRCIPMSWRCDGDIDCQNEEDE--KNCP 68

  Fly   174 FIEATCSSDQFRCG----------NGNCIPNKWRCDQESDCADGSDEANELCMN-ACPNNEFKCQ 227
             |...|.:::.:||          ...||||||.||.|.||.|.|||..  |.| :|...:|:|:
 Worm    69 -ISEVCGAEEHKCGEVKSARSSLERFKCIPNKWVCDGEFDCEDKSDEFQ--CKNVSCQEKQFQCE 130

  Fly   228 TV----DQCIPRSWLCDGSNDCRDKSDEAHCRART--CSPDEYACKSGEGQCVPLAWMCDQSKDC 286
            .:    ..|||.:|:|||..||.:..||.:|.::|  |..:.:.|.:  |.|:...|:||..:||
 Worm   131 ELSGDYSLCIPETWVCDGQRDCTNGKDEQNCTSKTSKCPDNNFQCSN--GNCIFKNWVCDGEEDC 193

  Fly   287 SDGSDE-----HNCNQT---CRADE-FTCGNGRCIQKRWKCDHDDDCGDGSDEKECPVVPCDSVA 342
            ||||||     .|||:|   |...| :.||:|.||..||:||.:.||.|.||||.|..:
 Worm   194 SDGSDELLTAPSNCNRTVNQCPPGEMWKCGSGECIPSRWRCDAEVDCKDHSDEKNCTAI------ 252

  Fly   343 EHTC---------TNGACIAKRWVCDGDPDCSDGSDERSCANVTKTTTPCLSHEYQCKDRITCLH 398
            :|||         .:..||.|.:||||:.||||||||..||:|          ..:||
 Worm   253 QHTCKLAEEFACKASHNCINKAFVCDGELDCSDGSDEDDCADV----------RTECK------- 300

  Fly   399 HSWLCDGDRDCPDGDDEHTANCKNVTCRADQFQCGDRSCIPGHLTCNGDKDCADGSDERDCGLSL 463
                 .|:|.||.....:.|...:|.            |||....|||::||.||.||::|.::.
 Worm   301 -----SGERTCPASYGAYGAESGHVV------------CIPASSWCNGEEDCPDGGDEKECNMTA 348

  Fly   464 SLGINQGGCNATSEFDCGGG--QCVPLSKVCDKRK-DCPDGEDEPAGKCGINE-CASKNGGCMHQ 524
            .:     .|...:|::|...  ||:.:||:|...: ||.||......:..|.| |...:.||:.:
 Worm   349 PV-----TCQKGTEYECPSTPLQCIEMSKLCASAQFDCGDGNMSVCSQKKIIEMCKPSSEGCVCR 408

  Fly   525 CIDLKVGHHCECHEGYKLSPDKRNCQDINECEVPGKCSQICVNEIGGFKCECEAGY---MRDPKN 586
            ...::..:.|.|.:||||  :...|.||||||:.|.|.|||:|..|.::|.|.|||   ..|.|.
 Worm   409 PSFVRGNNVCHCKDGYKL--ENGQCIDINECEIAGVCDQICLNIPGSYRCACHAGYQISFGDTKI 471

  Fly   587 HT-----RCKASEGHASLLLARRHDIRKIALDHMEMTSIVNSTKAATALDFVFRTGMIFWSDVTT 646
            .:     :|:|..|...:||..||.||:..|.:.....:.:|..:|.|:||....|.:.||||.:
 Worm   472 GSGRIANKCRAMGGDPLVLLTNRHTIRQFDLVNKMHFPVSSSPGSAVAMDFHILNGTLIWSDVLS 536

  Fly   647 QSIYKAPIDEGN-------------EKTVVLTKSSV-TSDGLAVDWIYNHVYFTDTHKCTIELTN 697
            :.|.|..|  ||             :..:|||...: |.|||||||:::.:::||.....|.:.:
 Worm   537 KQILKCSI--GNVSNAFLGTDMCDKKHEIVLTGDKIHTPDGLAVDWVHDLLFWTDGGLDQINVLD 599

  Fly   698 FEGSMGKVLVKDSLDIPRSIALDPIEGWMYWSDWGASPRIERAGMDGSHRTTIISYD-VKWPNGI 761
            .:....:||....|:.||:||:||..|.::|:|||...||||:||||.|||.|:..| |.||||:
 Worm   600 MKNGKQRVLYSSDLEEPRAIAVDPEVGLIFWTDWGKKARIERSGMDGQHRTVIVEGDRVVWPNGL 664

  Fly   762 TLDLVKKRIYWVDGKLNVISSANYDGSQRSQVLYSGEYLRHPFSITTFEDNVYWTDWDKQAVFKA 826
            .||.|.||:||.|.|:..|.|.:|.|.....||:|.:|||||||:..|||.:::|||:...|...
 Worm   665 ALDYVDKRVYWADAKIKSIFSCDYWGKNIKTVLHSHQYLRHPFSMAVFEDRLFYTDWEHDGVITV 729

  Fly   827 NKFTGEDVEPVTAMHMLQHPMVVHVYHPYRQPDGVNHCQSVNGHCSHLCLP------APRINERS 885
            |||||.|:.  |.|..::.||.|.:||...||...|.|:  |..|.|||||      ..|::|::
 Worm   730 NKFTGADIR--TVMDQVKSPMTVRIYHKQAQPLMQNKCE--NSECDHLCLPRAVYREKERVHEKT 790

  Fly   886 ----PRISCACPTGLKLMVDGLMCVEDPLYLPPVTRPPRARKTKPRPKSPRRRLPTGVQVGHADI 946
                | .||||..  ....|.|.|..|
 Worm   791 WHDRP-FSCACEG--TTASDVLECFAD-------------------------------------- 814

  Fly   947 RIEINDDLQLSTRLPLLPTTFVADQRPVKNHTQIEKTTTPSEQPDSGFIALVVIASLSGFAVLLS 1011
             :|....:.:.|...||..                          .|.:|       :||.::
 Worm   815 -LETKSGISMFTIFLLLCV--------------------------GGVVA-------AGFVIV-- 843

  Fly  1012 VLLLIGYRYCSKRRINSMNFENPIYRKTTTTEDH 1045
                  .|....|...::||:|||||:||...||
 Worm   844 ------RRKMGPRTFTALNFDNPIYRRTTEEADH 871

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LpR1	NP_001097934.2	LDLa	135..167	CDD:197566	16/32 (50%)
		LDLa	178..210	CDD:197566	16/41 (39%)
		LDLa	219..254	CDD:238060	14/38 (37%)
		LDLa	259..295	CDD:238060	15/40 (38%)
		LDLa	343..373	CDD:238060	18/38 (47%)
		LDLa	383..415	CDD:197566	6/31 (19%)
		Ldl_recept_a	423..459	CDD:278486	13/35 (37%)
		LDLa	476..504	CDD:197566	11/30 (37%)
		FXa_inhibition	514..549	CDD:291342	9/34 (26%)
		EGF_CA	551..581	CDD:214542	18/32 (56%)
		LY	662..702	CDD:214531	14/40 (35%)
		LY	704..747	CDD:214531	22/42 (52%)
		LY	749..790	CDD:214531	20/41 (49%)
		FXa_inhibition	864..905	CDD:291342	17/50 (34%)
T13C2.6	NP_872023.2	LDLa	36..67	CDD:238060	16/32 (50%)
		LDLa	73..117	CDD:238060	18/45 (40%)
		LDLa	122..161	CDD:238060	14/38 (37%)
		LDLa	167..199	CDD:197566	13/33 (39%)
		LDLa	214..249	CDD:238060	18/34 (53%)
		LDLa	261..292	CDD:238060	15/30 (50%)
		LDLa	<322..344	CDD:238060	12/21 (57%)
		EGF_CA	433..463	CDD:214542	17/29 (59%)
		LY	564..606	CDD:214531	14/41 (34%)
		LY	606..649	CDD:214531	22/42 (52%)
		LY	649..692	CDD:214531	22/42 (52%)
		LY	696..736	CDD:214531	22/39 (56%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166217
Domainoid	1	1.000	57	1.000	Domainoid score	I7233
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H443
Inparanoid	1	1.050	575	1.000	Inparanoid score	I562
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49125
OrthoDB	1	1.010	-	-		D179614at33208
OrthoFinder	1	1.000	-	-		FOG0002088
OrthoInspector	1	1.000	-	-		otm14761
orthoMCL	1	0.900	-	-		OOG6_103130
Panther	1	1.100	-	-	O	PTHR24270
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7933
SonicParanoid	1	1.000	-	-		X1052
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.940