Protein Alignment LpR1 and lrp-1

DIOPT Version :10

• Sequence 1: NP_001097934.2
• Gene: LpR1 / 2768687
• FlyBaseID: FBgn0066101
• Length: 1076
• Species: Drosophila melanogaster
• Sequence 2: NP_001379135.1
• Gene: lrp-1 / 172520
• WormBaseID: WBGene00003071
• Length: 4753
• Species: Caenorhabditis elegans
• Alignment Length: 825
• Identity: 299/825 - (36%)
• Similarity: 423/825 - (51%)
• Gaps: 84/825 - (10%)

  Fly   137 DEKQFQCHSGDCIPIRFVCDGDADCKDHSDEQIKEC---------------------KFIEATCS 180
            |.::..|.:..|..:.|....::    |.:|...:|                     :.||..||
 Worm   995 DSREHPCRASQCTQLCFATPSES----HPNELEAKCACRQGFMINKENNHSCQKDPAEKIEQLCS 1055

  Fly   181 SD--QFRCGNGNCIPNKWRCDQESDCADGSDEANE---LCMN--ACPNNEFKCQTVDQCIPRSWL 238
            |:  ||:|.||.|||.:|:||.|:||.|.|||.:|   .|.:  .|..|..||:...:|||..:.
 Worm  1056 SNSTQFQCKNGRCIPKEWKCDGENDCLDESDEIDEKGDKCFHETECAENTIKCRNTKKCIPAQYG 1120

  Fly   239 CDGSNDCRDKSDE--AHCR---ARTCSPDEYACKSGEGQCVPLAWMCDQSKDCSDGSDE--HNC- 295
            |||.|||.|.|||  .:|:   ...|:..::.|.:  .:|:|..|.||...||.|||||  ..|
 Worm  1121 CDGDNDCGDYSDEDVKYCKDGQKPVCAAKKFQCDN--HRCIPEQWKCDSDNDCGDGSDEKLEMCG 1183

  Fly   296 NQTCRADEFTCGNGRCIQKRWKCDHDDDCGDGSDE--KECPVVPCDSVAEHTCTNG-ACIAKRWV 357
            |.||.|::|:|.|||||...|.||.|:||.||:||  :.||.|.| |..:..|.|| .|:..|..
 Worm  1184 NATCAANQFSCANGRCIPIYWLCDGDNDCYDGTDEDKERCPPVQC-SALQFRCANGRQCVPLRNH 1247

  Fly   358 CDGDPDCSDGSDERSCANVTKTTTPCLSHEYQCKDRITCLHHSWLCDGDRDCPDGDDEHTANC-K 421
            |||..||.|||||.|||...::.||   .:::|.....|:..||.|||.:||.||.||....| .
 Worm  1248 CDGQSDCEDGSDEDSCAVTAESCTP---DQFKCVSSGLCIPASWKCDGQQDCDDGSDEPKFGCTS 1309

  Fly   422 NVTCRADQFQCGDRSCIPGHLTCNGDKDCADGSD---ERDCGLSLSLGINQGGCNATSEFD---C 480
            ...|.:|||:||:..||..:..|:|:.||.||||   ||.|..|:    |...|    .|:   |
 Worm  1310 GRQCSSDQFKCGNGRCILNNWLCDGENDCGDGSDESSERGCKTSM----NARKC----PFEHVAC 1366

  Fly   481 GGGQ--CVPLSKVCDKRKDCPDGEDEPAGKCGINECASKNGGCMHQCIDLKVGHHCECHEGYKLS 543
            ...|  |:||.::||.:..||.|.|| .|:|..:.|::...||..:|.:...|..|.|..|.:|
 Worm  1367 ENDQETCIPLHQLCDGKTHCPGGTDE-GGRCARDLCSADRAGCSFKCHNSPNGPICSCPFGEQL- 1429

  Fly   544 PDKRNCQDINECEVPGKCSQICVNEIGGFKCECEAGYMRDPKNHTRCKASEG--HASLLLARRHD 606
            .:|..|:..|||.....|||.|.:|..||.|.|:.||..|....| ||.::.  ...:.::.|:.
 Worm  1430 VNKTKCEPENECLDSSSCSQRCKDEKHGFTCSCDEGYELDVDKRT-CKVADNVKDTRIYVSNRNR 1493

  Fly   607 I--RKIALDHMEMTSIVNSTKAATALDFVFRTGMIFWSDVTTQSIYKAPIDEGNEKTVVLTKSSV 669
            |  ....||:......:.....|.|.|.:  |..|:|||:..:.|..|. ..|...||.:.....
 Worm  1494 IYYSDHKLDNWHTFGAIVENAIALAWDSL--TDRIYWSDIREKKILSAN-RNGTNATVFIADGLD 1555

  Fly   670 TSDGLAVDWIYNHVYFTDTHKCTIELTNFEGSMGK-VLVKDSLDIPRSIALDPIEGWMYWSDWGA 733
            .::|:|:||:..::|:.|:...|||:.|.|....: :||..::..||.||:||.:|.|:|:|||.
 Worm  1556 ITEGIALDWVGRNLYWVDSSLNTIEVANLEDPKQRTLLVHQNVSQPRGIAVDPRKGVMFWTDWGQ 1620

  Fly   734 SPRIERAGMDGSHRTTIISYDVKWPNGITLDLVKKRIYWVDGKLNVISSANYDGSQRSQVLYSGE 798
            :|.||||.|||:.|..|:...:.|||.|.||....|:|:.|.||:.|...|||||.|:|||.|.:
 Worm  1621 NPCIERASMDGTDRQIIVKTKIYWPNTIALDYTTDRVYFADSKLDFIDFVNYDGSGRTQVLASSK 1685

  Fly   799 YLRHPFSITTFEDNVYWTDWDKQAVFKANKFTGEDVEPVTAMHMLQHPMVVHVYHPYRQPDGVNH 863
            :::||.::..|||.:|::|...|.:....|:.........: |.....:.|...||..||...|:
 Worm  1686 FVQHPHALAIFEDMMYYSDRRLQKLQVYPKYPNGTTSEYPS-HTFSKALGVVAVHPVLQPVIKNN 1749

  Fly   864 CQSVNGHCSHLCLPAPRINERSPRISCACPTGLKLMVDGLMCVED 908
            ..|.| .||||||    :|.:: ..:|.||.|.||...|..|::|
 Worm  1750 PCSTN-PCSHLCL----LNNKN-TFTCKCPMGEKLDASGKKCIDD 1788

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LpR1	NP_001097934.2	LDLa	135..167	CDD:197566	5/29 (17%)
		LDLa	178..210	CDD:197566	19/33 (58%)
		LDLa	219..254	CDD:238060	17/36 (47%)
		LDLa	259..295	CDD:238060	14/37 (38%)
		LDLa	343..373	CDD:238060	15/30 (50%)
		LDLa	383..415	CDD:197566	11/31 (35%)
		Ldl_recept_a	423..459	CDD:395011	18/38 (47%)
		LDLa	476..504	CDD:197566	11/32 (34%)
		FXa_inhibition	514..549	CDD:464251	10/34 (29%)
		EGF_CA	551..581	CDD:214542	13/29 (45%)
		LY	662..702	CDD:214531	12/39 (31%)
		LY	704..747	CDD:214531	22/43 (51%)
		LY	749..790	CDD:214531	18/40 (45%)
		Ldl_recept_b	769..815	CDD:459654	21/45 (47%)
		FXa_inhibition	864..905	CDD:464251	16/40 (40%)
lrp-1	NP_001379135.1	LDLa	53..87	CDD:238060
		LDLa	92..131	CDD:238060
		LDLa	140..173	CDD:238060
		LDLa	182..216	CDD:238060
		LDLa	223..257	CDD:238060
		LDLa	262..297	CDD:238060
		YncE	<376..564	CDD:442618
		LY	547..589	CDD:214531
		LY	883..925	CDD:214531
		LDLa	1057..1087	CDD:197566	16/29 (55%)
		LDLa	1100..1133	CDD:197566	15/32 (47%)
		LDLa	1146..1177	CDD:197566	12/32 (38%)
		LDLa	1187..1219	CDD:238060	18/31 (58%)
		LDLa	1228..1263	CDD:238060	17/35 (49%)
		LDLa	1270..1302	CDD:238060	13/34 (38%)
		LDLa	1313..1344	CDD:238060	15/30 (50%)
		FXa_inhibition	1447..1475	CDD:464251	13/28 (46%)
		LY	1511..1545	CDD:214531	11/36 (31%)
		LY	1548..1585	CDD:214531	11/36 (31%)
		LY	1590..1634	CDD:214531	22/43 (51%)
		LY	1635..1677	CDD:214531	18/41 (44%)
		Vgb	<1921..2043	CDD:443399
		LY	2193..2239	CDD:214531
		LY	2240..2283	CDD:214531
		LY	2284..2325	CDD:214531
		Ldl_recept_b	2582..2629	CDD:459654
		LY	2613..2655	CDD:214531
		LDLa	2794..2824	CDD:197566
		LDLa	2834..2868	CDD:238060
		LDLa	2874..2907	CDD:197566
		LDLa	2961..2994	CDD:238060
		LDLa	3012..3038	CDD:238060
		LDLa	3048..3088	CDD:197566
		LDLa	3099..3131	CDD:197566
		LDLa	3140..3174	CDD:238060
		LDLa	3186..3218	CDD:197566
		FXa_inhibition	3276..3305	CDD:464251
		LY	3382..3424	CDD:214531
		Ldl_recept_b	3445..3491	CDD:459654
		LY	3476..3516	CDD:214531
		FXa_inhibition	3586..3623	CDD:464251
		LDLa	3627..3660	CDD:197566
		LDLa	3671..3705	CDD:238060
		LDLa	3792..3825	CDD:197566
		LDLa	3837..3868	CDD:238060
		LDLa	3878..3912	CDD:238060
		LDLa	3917..3951	CDD:238060
		LDLa	3958..3990	CDD:197566
		LDLa	4049..4083	CDD:238060
		FXa_inhibition	4097..>4121	CDD:464251
		EGF_CA	4132..4163	CDD:214542
		NHL	4219..>4431	CDD:302697
		NHL repeat	4219..4257	CDD:271332
		NHL repeat	4267..4330	CDD:271332
		NHL repeat	4333..4371	CDD:271332
		NHL repeat	4373..4410	CDD:271332