DRSC/TRiP Functional Genomics Resources

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Protein Alignment LpR1 and lrp-2

DIOPT Version :9

Sequence 1:NP_001097934.2 Gene:LpR1 / 2768687 FlyBaseID:FBgn0066101 Length:1076 Species:Drosophila melanogaster
Sequence 2:NP_491270.2 Gene:lrp-2 / 171981 WormBaseID:WBGene00003072 Length:4858 Species:Caenorhabditis elegans


Alignment Length:837 Identity:288/837 - (34%)
Similarity:408/837 - (48%) Gaps:100/837 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   136 CDEKQFQCHSGDCIPIRFVCDGDADCKDHSDEQIKECKFIEATCSSDQFRCGNGNCIPNKWRCDQ 200
            |....|.|.:|.|||.:.||:...||.:.:||.       ..||:.::|||.:|.|||:|.||:.
 Worm  2681 CRPGYFNCGNGLCIPEQKVCNRINDCANFADES-------NCTCNENEFRCQSGACIPSKARCNH 2738

  Fly   201 ESDCADGSDEANELCMNACPNNEF------KCQTVDQCIPRSWLCDGSNDCRDKSDEAHC----- 254
            ..||.|.|||......|....|||      .|.|..|||..||.|||:|||.|.|||..|     
 Worm  2739 MQDCNDASDEIGCPFRNCSALNEFGMTGLINCATTSQCIHPSWKCDGTNDCYDGSDEKDCFVEFD 2803

  Fly   255 -------RARTC-SPDEYACKSGEGQCVPLAWMCDQSKDCSDGSDEHNCN-QTCRADEFTC-GNG 309
                   ..|:| :..::||.:.. .|:|..|.||...||:|||||.||: :.|.:.||:| .:.
 Worm  2804 ATGGSVSAPRSCDAKTQFACLATR-TCMPKHWQCDGQPDCADGSDEKNCDAKKCTSFEFSCESSK 2867

  Fly   310 RCIQKRWKCDHDDDCGDGSDEKECPVVPCDSV---AEHTCTNGACIAKRWVCDGDPDCSD----- 366
            :||....|||...||.||.||.:|. ..|||.   |...|||..||...|.|||..||.|     
 Worm  2868 KCIPLEQKCDGRRDCPDGEDEHQCE-TECDSKGGNATFRCTNHRCIPMAWRCDGTDDCMDNAKSL 2931

  Fly   367 GSDERSC-ANVTKTTTPCLSHEYQCKDR---ITCLHHSWLCDGDRDCPDGDDEHTANCKNV--TC 425
            ||||..| |..|....|.     :|.|.   :.|...:.||||.:||.||.||  .||.::  .|
 Worm  2932 GSDEVDCAAGRTSFHVPS-----RCADETCVVACELTAVLCDGIQDCSDGFDE--KNCASLDRQC 2989

  Fly   426 RADQFQCGDRSCIPGHLTCNGDKDCADGSDE--RDCGLSLSLGINQGGCNATSEFDC----GGGQ 484
            :.:::.|....||.....|:...||.|||||  ..|.||..   .:.||  .|.:.|    |...
 Worm  2990 KPNEWMCDSGQCIDSGRLCDASVDCVDGSDEWVEICSLSEP---PRRGC--PSGWSCLLTNGTIG 3049

  Fly   485 CVPLSKVCDKRKDCPDGEDE----PAGKCGI--NECASKNGGCMHQCIDLKVG-HHCECHEGYKL 542
            |:...::||.|:||..|.||    |.|.|..  |.| .:...|...     .| ..|.|.:||.|
 Worm  3050 CLQEQQLCDGRRDCMSGIDEQCDNPQGNCSSTRNSC-DQTWNCQRH-----AGFESCSCDDGYHL 3108

  Fly   543 SP-DKRNCQDINECEVPGKCSQICVNEIG-GFKCECEAGYMRDPKNHTRCKASEG-HASLLLARR 604
            || ||:.|.....|. ...||..|::... |.:|.|..||:.. :|...|:.::. .|.:|:...
 Worm  3109 SPYDKKTCLRSPSCP-KANCSHFCIDRRDVGHQCFCAPGYILS-ENQKDCRRNDTIEAEILMVYG 3171

  Fly   605 HDIRKIALD-HMEMTSIVNSTKAATALDFVFRTGMIFWSDVTTQSIYKAPI----DEGNEKTVVL 664
            |.::...:| |.:.|.:.|.|. ..|||:..::.:::|:||.... .||.|    ::.|...|:.
 Worm  3172 HRLKLFTIDGHAKATLLSNLTN-GVALDYDVKSDLVYWTDVAHDG-NKAGITSMSNQPNTYRVIN 3234

  Fly   665 TKSSVTSDGLAVDWIYNHVYFTDTHKCTIELTNFEGSMGKVLVKDS-LDIPRSIALDPIEGWMYW 728
            :..:...||:||||:..::|:||.:...|.:.:..|...::|:|.: |:.||:|.|||::..::|
 Worm  3235 SLPTKGIDGIAVDWLGRNIYYTDRNHDAIAVCDMRGRFNRILLKGTPLNDPRAIVLDPLQALVFW 3299

  Fly   729 SDWGASPRIERAGMDGSHRTTII-SYDVKWPNGITLDLVKKRIYWVDGKLNVISSANYDGSQRSQ 792
            :|||||..|.|..||||:...|: ...::|||.:.:|...:|:|:.|...:.|:|.|||||:|..
 Worm  3300 TDWGASAHIGRMNMDGSNEQVILQDRTIRWPNALAVDAPAQRLYFGDAHRDYIASCNYDGSKRRM 3364

  Fly   793 VLYSGEYLRHPFSITTFEDNVYWTDWDKQAVFKANKFTGEDVEPVTAMHMLQHPMVVHVYHPYRQ 857
            ||...  :||.|::..|||.|||:||....:.:.:|.||.: ..|........||...:.||..|
 Worm  3365 VLRGS--VRHIFALAVFEDYVYWSDWHNHTIERVHKITGTN-RKVLIQDKQYRPMGFKIVHPSLQ 3426

  Fly   858 PDG----VNHCQSVNGHCSHLCLPA--PRINERSPRISCACPTGLKLMVDGLMCVED 908
            ..|    ..|..|....|.:||:||  |.:...|...:|.|..|.:  .:|..||.:
 Worm  3427 SMGSLKTARHPCSQPARCDNLCIPANTPDLTTSSDNFTCMCAQGFR--SEGRSCVSE 3481

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LpR1NP_001097934.2 LDLa 135..167 CDD:197566 11/30 (37%)
LDLa 178..210 CDD:197566 16/31 (52%)
LDLa 219..254 CDD:238060 20/40 (50%)
LDLa 259..295 CDD:238060 15/36 (42%)
LDLa 343..373 CDD:238060 16/34 (47%)
LDLa 383..415 CDD:197566 11/34 (32%)
Ldl_recept_a 423..459 CDD:278486 12/39 (31%)
LDLa 476..504 CDD:197566 10/31 (32%)
FXa_inhibition 514..549 CDD:291342 12/36 (33%)
EGF_CA 551..581 CDD:214542 8/30 (27%)
LY 662..702 CDD:214531 12/39 (31%)
LY 704..747 CDD:214531 21/43 (49%)
LY 749..790 CDD:214531 15/41 (37%)
FXa_inhibition 864..905 CDD:291342 12/42 (29%)
lrp-2NP_491270.2 LDLa 80..119 CDD:197566
LDLa 130..162 CDD:197566
LY 668..702 CDD:214531
LY 707..758 CDD:214531
LY 759..801 CDD:214531
LDLa 968..1000 CDD:197566
LDLa 1013..1047 CDD:238060
LDLa 1053..1087 CDD:238060
LDLa 1098..1129 CDD:238060
LDLa 1144..1175 CDD:238060
LDLa 1182..1216 CDD:238060
FXa_inhibition 1276..1305 CDD:291342
LY 1421..1463 CDD:214531
LY 1465..1508 CDD:214531
LY 1521..1555 CDD:214531
LY 2480..2521 CDD:214531
LDLa 2681..2715 CDD:238060 13/40 (33%)
LDLa 2717..2751 CDD:238060 17/33 (52%)
LDLa <2774..2798 CDD:238060 15/23 (65%)
LDLa 2819..2851 CDD:238060 14/32 (44%)
LDLa 2856..2891 CDD:238060 15/34 (44%)
LDLa 2904..2938 CDD:238060 16/33 (48%)
LDLa 2988..3020 CDD:197566 10/31 (32%)
LY 3231..3270 CDD:214531 11/38 (29%)
Ldl_recept_b 3296..3336 CDD:278487 16/39 (41%)
LY 3319..3362 CDD:214531 15/42 (36%)
LY 3363..3404 CDD:214531 16/43 (37%)
LDLa 3481..3514 CDD:197566 0/1 (0%)
LDLa 3574..3609 CDD:238060
LDLa 3614..3649 CDD:197566
LDLa 3659..3693 CDD:238060
LDLa 3881..3912 CDD:238060
LY 4084..4125 CDD:214531
LY 4139..4181 CDD:214531
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S4504
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.860

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