DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LpR1 and Lrp8

DIOPT Version :9

Sequence 1:	NP_001097934.2	Gene:	LpR1 / 2768687	FlyBaseID:	FBgn0066101	Length:	1076	Species:	Drosophila melanogaster
Sequence 2:	XP_011238756.1	Gene:	Lrp8 / 16975	MGIID:	1340044	Length:	1010	Species:	Mus musculus

Alignment Length:	986	Identity:	357/986 - (36%)
Similarity:	507/986 - (51%)	Gaps:	136/986 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 PLGIGQSLEAKCDEKQFQCHSGDCIPIRFVCDGDADCKDHSDEQIKECKFIEATCSSDQFRCGNG 189
            ||..||....:|:|.||:|.:..|||:.:.||.|.||.|:|||.  :|.  :.||:...|.|.||
Mouse    30 PLPGGQGPVKECEEDQFRCRNERCIPLVWRCDEDNDCSDNSDED--DCP--KRTCADSDFTCDNG 90

  Fly   190 NCIPNKWRCDQESDCADGSDEANELCMNACPNNEFKCQTVDQCIPRSWLCDGSNDCRDKSDEAHC 254
            :|||.:|:||.|.:|.|||||:                                       :|.|
Mouse    91 HCIPERWKCDGEEECPDGSDES---------------------------------------KATC 116

  Fly   255 RARTCSPDEYACKSGEGQCVPLAWMCDQSKDCSDGSDEHNCNQTCRADEFTCGNGRCIQKRWKCD 319
            .:..|..::.:|.....:|||.:|.||..|||..|:||..|...|...||.|.|..|:...:.||
Mouse   117 SSEECPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCPTLCAPHEFQCSNRSCLASVFVCD 181

  Fly   320 HDDDCGDGSDEKECPVVPCDSVAEHTC-TNGACIAKRWVCDGDPDCSDGSDE------RSCANVT 377
            .||||||||||:.|....|.. .|..| ..|.||.:|||||...||.|.|||      |:....|
Mouse   182 GDDDCGDGSDERGCSDPACPP-REFRCGGGGTCIPERWVCDRQFDCEDRSDEAAELCGRAGQGTT 245

  Fly   378 KTTTPCL-SHEYQCKDRITCLHHSWLCDGDRDCPDGDDEHTANCKNV-TCRADQFQCGDRSCIPG 440
            .|...|. :.::.|:.. .|:|..|.|||||||.|..||  |:|... .||.::|||||.:|:..
Mouse   246 ATPAACAPTAQFTCRSG-ECIHLGWRCDGDRDCKDKSDE--ADCSAPGPCRENEFQCGDGTCVLA 307

  Fly   441 HLTCNGDKDCADGSDERDCGLSLSLGINQGGCNATSEFDCGGGQCVPLSKVCDKRKDCPDGEDEP 505
            ...||.::||.|||||..|       :.:..|.....|.|..|:||...||||.::||.|..|||
Mouse   308 IKRCNQERDCPDGSDEAGC-------LQESTCEGPRRFQCKSGECVDGGKVCDDQRDCRDWSDEP 365

  Fly   506 AGKC-------------GINECASKNGGCMHQCIDLKVGHHCECHEGYKLSPDKRNCQDINECEV 557
            ...|             |:|||...||||.|.|.|||:|..|.|..|::|. |::.|.||:||:.
Mouse   366 QKVCVAPSFPGNRRHPRGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLL-DQKTCGDIDECQD 429

  Fly   558 PGKCSQICVNEIGGFKCECEAGYMRD--PKNHTRCKASEGHA-SLLLARRHDIRKIALDHMEMTS 619
            |..|||||||..|.|||||..||..|  .||   |||..|.: ||:...||::|:|.|...:.:.
Mouse   430 PDACSQICVNYKGYFKCECHPGYEMDTLTKN---CKAVAGKSPSLIFTNRHEVRRIDLVKRDYSR 491

  Fly   620 IVNSTKAATALDFVFRTGMIFWSDVTTQSIYKAPIDEG---NEKTVVLTKSSVTSDGLAVDWIYN 681
            ::...|...|||....|..|:|.|::.:.||.|.:|:.   :|:.|::.:...:.:||||||::.
Mouse   492 LIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAHMDKASIPDEQVVLIDEQLHSPEGLAVDWVHK 556

  Fly   682 HVYFTDTHKCTIELTNFEGSMGKVLVKDSLDIPRSIALDPIEGWMYWSDWGASPRIERAGMDGSH 746
            |:|:||:...||.:...:|.....|....|..||:||:||:.|:|||||||...:||:||::|:.
Mouse   557 HIYWTDSGNKTISVATTDGRRRCTLFSRELSEPRAIAVDPLRGFMYWSDWGFQAKIEKAGLNGAD 621

  Fly   747 RTTIISYDVKWPNGITLDLVKKRIYWVDGKLNVISSANYDGSQRSQVLYSGEYLRHPFSITTFED 811
            |.|::|.:::|||||||||:.:|:||||.||:.:||.:::|..|..:::|.::|.|||.:..|||
Mouse   622 RQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFNGGNRKMLIFSTDFLSHPFGVAVFED 686

  Fly   812 NVYWTDWDKQAVFKANKFTGEDVEPVTAMHMLQHPMVVHVYHPYRQPDGVNHCQ---SVNGHCSH 873
            .|:|||.:.:|:|.||:..|  :|.......|.:|..:.::|..:||...:.|.   ..||.|.:
Mouse   687 KVFWTDLENEAIFSANRLNG--LEIAILAENLNNPHDIVIFHELKQPKAADACDLSAQPNGGCEY 749

  Fly   874 LCLPAPRINERSPRISCACPTGLKLMVDGLMCVEDP-------------LYLPPVTRPPRARKTK 925
            ||||||:|:..||:.:||||..:.|..|...|...|             ..:|..||.|......
Mouse   750 LCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASAMTRTVPATTRAPGTTIHD 814

  Fly   926 PRPKSPRRRLPTGVQVG-HADIRIEINDDLQLSTRLPLLPTTFVADQRP-VKNHTQ------IEK 982
            |..::.....|:..... |             |..:|..|:|..:...| ..||:|      .:.
Mouse   815 PTYQNHSTETPSQTAAAPH-------------SVNVPRAPSTSPSTPSPATSNHSQHYGNEGSQM 866

  Fly   983 TTTPSEQPDSGFIALVVIASL--SGFAVLLSVLLLIGYRYCSKRRINSMNFENPIYRKTTTTEDH 1045
            .:|.:.......:.:||||.|  ||:.:         :|...::...||||:||:|||||..|:.
Mouse   867 GSTVTAAVIGVIVPIVVIALLCMSGYLI---------WRNWKRKNTKSMNFDNPVYRKTTEEEEE 922

  Fly  1046 FSLRKNLPARI 1056
            ..|.....|:|
Mouse   923 DELHIGRTAQI 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LpR1	NP_001097934.2	LDLa	135..167	CDD:197566	15/31 (48%)
		LDLa	178..210	CDD:197566	17/31 (55%)
		LDLa	219..254	CDD:238060	1/34 (3%)
		LDLa	259..295	CDD:238060	14/35 (40%)
		LDLa	343..373	CDD:238060	17/36 (47%)
		LDLa	383..415	CDD:197566	13/32 (41%)
		Ldl_recept_a	423..459	CDD:278486	17/36 (47%)
		LDLa	476..504	CDD:197566	12/27 (44%)
		FXa_inhibition	514..549	CDD:291342	16/34 (47%)
		EGF_CA	551..581	CDD:214542	19/29 (66%)
		LY	662..702	CDD:214531	14/39 (36%)
		LY	704..747	CDD:214531	21/42 (50%)
		LY	749..790	CDD:214531	21/40 (53%)
		FXa_inhibition	864..905	CDD:291342	19/43 (44%)
Lrp8	XP_011238756.1	LDLa	41..75	CDD:238060	17/35 (49%)
		LDLa	79..111	CDD:197566	17/31 (55%)
		LDLa	121..157	CDD:238060	14/35 (40%)
		LDLa	200..232	CDD:197566	15/32 (47%)
		LDLa	256..286	CDD:238060	15/32 (47%)
		LDLa	292..326	CDD:238060	17/33 (52%)
		LDLa	330..366	CDD:381805	15/35 (43%)
		FXa_inhibition	387..421	CDD:373209	16/34 (47%)
		EGF_CA	423..453	CDD:214542	19/29 (66%)
		LY	492..527	CDD:214531	11/34 (32%)
		LY	537..578	CDD:214531	14/40 (35%)
		Ldl_recept_b	599..639	CDD:278487	22/39 (56%)
		LY	623..665	CDD:214531	21/41 (51%)
		Ldl_recept_b	686..725	CDD:278487	13/40 (33%)
		FXa_inhibition	744..781	CDD:373209	18/36 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	55	1.000	Domainoid score	I11056
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	712	1.000	Inparanoid score	I637
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49125
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002088
OrthoInspector	1	1.000	-	-		mtm8782
orthoMCL	1	0.900	-	-		OOG6_103130
Panther	1	1.100	-	-	O	PTHR24270
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7933
SonicParanoid	1	1.000	-	-		X1052
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.000