DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LpR1 and Ldlr

DIOPT Version :9

Sequence 1:	NP_001097934.2	Gene:	LpR1 / 2768687	FlyBaseID:	FBgn0066101	Length:	1076	Species:	Drosophila melanogaster
Sequence 2:	NP_034830.2	Gene:	Ldlr / 16835	MGIID:	96765	Length:	862	Species:	Mus musculus

Alignment Length:	899	Identity:	343/899 - (38%)
Similarity:	490/899 - (54%)	Gaps:	112/899 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 EATCSSDQFRCGNGNCIPNKWRCDQESDCADGSDEANELCMN-ACPNNEFKC-QTVDQCIPRSWL 238
            |.:||.::|:|.:|.||.:||.||...:|.|||||:.|.||: .|.:|:|.| ..|.:|||.||.
Mouse    24 EDSCSRNEFQCRDGKCIASKWVCDGSPECPDGSDESPETCMSVTCQSNQFSCGGRVSRCIPDSWR 88

  Fly   239 CDGSNDCRDKSDEAHCRARTCSPDEYACKSGEGQCVPLAWMCDQSKDCSDGSDEHNCN-QTCRAD 302
            |||..||.:.|||..|..:|||.|::.|:  :|:|:...::||..:||.|||||.:|. .||...
Mouse    89 CDGQVDCENDSDEQGCPPKTCSQDDFRCQ--DGKCISPQFVCDGDRDCLDGSDEAHCQATTCGPA 151

  Fly   303 EFTCGNGRCIQKRWKCDHDDDCGDGSDEKECPVVPCDSVAEHTCTNGACIAKRWV--CDGDPDCS 365
            .|.|.:..||...|.||.|.||.|||||                         |.  |.|....|
Mouse   152 HFRCNSSICIPSLWACDGDVDCVDGSDE-------------------------WPQNCQGRDTAS 191

  Fly   366 DGSDERSCANVTKTTTPCLSHEYQCKDRITCLHHSWLCDGDRDCPD-GDDEHTANCKNVTCRADQ 429
            .|           .::||.|.|:.|... .|:|.||:|||:.||.| .|:||   |...|||.|:
Mouse   192 KG-----------VSSPCSSLEFHCGSS-ECIHRSWVCDGEADCKDKSDEEH---CAVATCRPDE 241

  Fly   430 FQCGDRSCIPGHLTCNGDKDCADGSDERDCGLSLSLGINQGGCNATSEFDCGGGQCVPLSKVCDK 494
            |||.|.|||.|...|:.:.||.|.|||..|       :|...|:..::|.|..|:|:.|.||||.
Mouse   242 FQCADGSCIHGSRQCDREHDCKDMSDELGC-------VNVTQCDGPNKFKCHSGECISLDKVCDS 299

  Fly   495 RKDCPDGEDEPAGKCGINECASKNGGCMHQCIDLKVGHHCECHEGYKLSPDKRNCQDINECEVPG 559
            .:||.|..|||..:|..|||...||||.|.|.|||:|..|.|..|::| .|...|:||:||:.|.
Mouse   300 ARDCQDWSDEPIKECKTNECLDNNGGCSHICKDLKIGSECLCPSGFRL-VDLHRCEDIDECQEPD 363

  Fly   560 KCSQICVNEIGGFKCECEAGYMRDPKNHTR-CKASEGHASLLLARRHDIRKIALDHMEMTSIVNS 623
            .|||:|||..|.:||||:||:..||  ||| |||......||...||::||:.||..|.||::.:
Mouse   364 TCSQLCVNLEGSYKCECQAGFHMDP--HTRVCKAVGSIGYLLFTNRHEVRKMTLDRSEYTSLLPN 426

  Fly   624 TKAATALDFVFRTGMIFWSDVTTQSIYKAPIDEGNEKT--VVLTKSSVTSDGLAVDWIYNHVYFT 686
            .|...|||.......|:|||::.:.||.|.:|:....:  .::::.....||||||||:.::|:|
Mouse   427 LKNVVALDTEVTNNRIYWSDLSQKKIYSALMDQAPNLSYDTIISEDLHAPDGLAVDWIHRNIYWT 491

  Fly   687 DTHKCTIELTNFEGSMGKVLVKDSLDIPRSIALDPIEGWMYWSDWGASPRIERAGMDGSHRTTII 751
            |:...::.:.:.:|...:.|.:::...||:|.:||:.|:|||:|||...:|::.|::|....:::
Mouse   492 DSVPGSVSVADTKGVKRRTLFQEAGSRPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIHSLV 556

  Fly   752 SYDVKWPNGITLDLVKKRIYWVDGKLNVISSANYDGSQRSQVLYSGEYLRHPFSITTFEDNVYWT 816
            :.:::|||||||||...|:||||.||:.|||.:.:|..|..:|.....|.||||:..:||.||||
Mouse   557 TENIQWPNGITLDLSSGRLYWVDSKLHSISSIDVNGGNRKTILEDENRLAHPFSLAIYEDKVYWT 621

  Fly   817 DWDKQAVFKANKFTGEDVEPVTAMHMLQHPMVVHVYHPYRQPDGVNHCQSV----NGHCSHLCLP 877
            |...:|:|.||:.||.||. :.|.::|. |..:.::|...||.|||.|::.    ||.|.:||||
Mouse   622 DVINEAIFSANRLTGSDVN-LVAENLLS-PEDIVLFHKVTQPRGVNWCETTALLPNGGCQYLCLP 684

  Fly   878 APRINERSPRISCACPTGLKLMVDGLMCVED--------------PLYLPPVTRPPRARKTKPRP 928
            ||:|...||:.:||||.|:.|..|...|:.:              |:.....||||:..:....|
Mouse   685 APQIGPHSPKFTCACPDGMLLAKDMRSCLTEVDTVLTTQGTSAVRPVVTASATRPPKHSEDLSAP 749

  Fly   929 KSPRRRLPTGVQVGHADIRIEINDDLQLSTRLPLLPTTFVADQRPVKNHTQIEKTTTPSEQPDSG 993
            .:||:.:.|                       |.|.|  ||.. .|.:..|.:.....:|:...|
Mouse   750 STPRQPVDT-----------------------PGLST--VASV-TVSHQVQGDMAGRGNEEQPHG 788

  Fly   994 --FIALVVIASLSGFAVLLSVLLLIGYRYCSKRRINSMNFENPIYRKTTTTEDH 1045
              |:::....:|....||.:|||...:|.   :.|||:||:||:|:|||..|.|
Mouse   789 MRFLSIFFPIALVALLVLGAVLLWRNWRL---KNINSINFDNPVYQKTTEDELH 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LpR1	NP_001097934.2	LDLa	135..167	CDD:197566
		LDLa	178..210	CDD:197566	15/31 (48%)
		LDLa	219..254	CDD:238060	18/35 (51%)
		LDLa	259..295	CDD:238060	15/35 (43%)
		LDLa	343..373	CDD:238060	5/31 (16%)
		LDLa	383..415	CDD:197566	15/32 (47%)
		Ldl_recept_a	423..459	CDD:278486	19/35 (54%)
		LDLa	476..504	CDD:197566	12/27 (44%)
		FXa_inhibition	514..549	CDD:291342	16/34 (47%)
		EGF_CA	551..581	CDD:214542	18/29 (62%)
		LY	662..702	CDD:214531	12/39 (31%)
		LY	704..747	CDD:214531	16/42 (38%)
		LY	749..790	CDD:214531	20/40 (50%)
		FXa_inhibition	864..905	CDD:291342	20/44 (45%)
Ldlr	NP_034830.2	Ldl_recept_a	25..58	CDD:278486	15/32 (47%)
		Ldl_recept_a	66..104	CDD:278486	18/37 (49%)
		Ldl_recept_a	107..143	CDD:278486	16/37 (43%)
		Ldl_recept_a	146..184	CDD:278486	18/62 (29%)
		Ldl_recept_a	196..232	CDD:278486	18/39 (46%)
		Ldl_recept_a	236..271	CDD:278486	19/34 (56%)
		Ldl_recept_a	279..309	CDD:278486	12/29 (41%)
		FXa_inhibition	319..>347	CDD:291342	14/27 (52%)
		EGF_CA	355..389	CDD:214542	20/35 (57%)
		LDL-receptor class B 1	398..439		15/40 (38%)
		LY	420..458	CDD:214531	13/37 (35%)
		LDL-receptor class B 2	440..485		15/44 (34%)
		Ldl_recept_b	440..482	CDD:278487	12/41 (29%)
		LDL-receptor class B 3	486..528		10/41 (24%)
		Ldl_recept_b	486..525	CDD:278487	8/38 (21%)
		LDL-receptor class B 4	529..572		19/42 (45%)
		Ldl_recept_b	529..569	CDD:278487	16/39 (41%)
		LY	553..595	CDD:214531	20/41 (49%)
		LDL-receptor class B 5	573..615		18/41 (44%)
		LDL-receptor class B 6	616..658		18/43 (42%)
		Ldl_recept_b	616..655	CDD:278487	17/40 (43%)
		FXa_inhibition	675..712	CDD:291342	19/36 (53%)
		Clustered O-linked oligosaccharides	722..770		14/73 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	730..761		10/53 (19%)
		Required for MYLIP-triggered down-regulation of LDLR. /evidence=ECO:0000250\|UniProtKB:P01130	813..862		14/30 (47%)
		NPXY motif. /evidence=ECO:0000250\|UniProtKB:P01130	825..830		3/4 (75%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	55	1.000	Domainoid score	I11056
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	712	1.000	Inparanoid score	I637
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49125
OrthoDB	1	1.010	-	-		D179614at33208
OrthoFinder	1	1.000	-	-		FOG0002088
OrthoInspector	1	1.000	-	-		mtm8782
orthoMCL	1	0.900	-	-		OOG6_103130
Panther	1	1.100	-	-	O	PTHR24270
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1052
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.980