DRSC/TRiP Functional Genomics Resources

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Protein Alignment LpR1 and lrp2b

DIOPT Version :9

Sequence 1:NP_001097934.2 Gene:LpR1 / 2768687 FlyBaseID:FBgn0066101 Length:1076 Species:Drosophila melanogaster
Sequence 2:XP_021335953.1 Gene:lrp2b / 101886177 ZFINID:ZDB-GENE-111115-1 Length:4577 Species:Danio rerio


Alignment Length:989 Identity:345/989 - (34%)
Similarity:471/989 - (47%) Gaps:181/989 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    61 GFGKCCTAT-----PTPLNTPSTNTPTSAVSPHNPQTLDESGSLSKVIDGKA-----FINMGFKF 115
            |.|....||     |..::..|.:...|..||..   |...|.....:.|.|     ..:.|..:
Zfish  2591 GSGLTIMATDLQYRPNDIHVFSASRQESCSSPCQ---LFNGGCSHVCVPGPAGPECQCPSTGNWY 2652

  Fly   116 LNVSGKIGTPLGIGQSLEAKCDEKQFQCHSGDCIPIRFVCDGDADCKDHSDEQIKECKFIEATCS 180
            |...||...| ..||    :|...||.|..|.|:...|.|||..||.|.|||..:.|.|  .|||
Zfish  2653 LANEGKDCIP-DNGQ----RCHADQFTCLDGRCLSQNFKCDGYRDCLDGSDELERVCAF--HTCS 2710

  Fly   181 SDQFRCGNGNCIPNKWRCDQESDCADGSDE----------------ANELCMNA----------- 218
            ..:|.|.||.|:|..:.||..:||.|.|||                ||..|::|           
Zfish  2711 PTEFTCDNGGCVPLYYVCDYTNDCGDNSDEHGCPFPTCNPSTEFTCANGRCISAAYVCDGINDCR 2775

  Fly   219 ---------CPNNE-----FKCQTVDQCIPRSWLCDGSNDCRDKSDE--AHCRARTCSPDEYACK 267
                     ||:..     .||.|.:.|||.|.||||.|:|.|.|||  ..|..||||.||:.|.
Zfish  2776 DNGTTDEVNCPDRTCAPGLVKCDTTNICIPSSSLCDGHNNCGDNSDENPLFCAGRTCSADEFRCD 2840

  Fly   268 SGEGQCVPLAWMCDQSKDCSDGSDE-HNCNQ---TCRADEFTCGNGRCIQKRWKCDHDDDCGDGS 328
            |  |:|:|..|:||:..||.||:|| ..|..   ||...:|.|.||.|||:.|.||.::||||.|
Zfish  2841 S--GKCIPQFWVCDRISDCLDGTDEPPTCEDHIYTCSPQQFNCANGNCIQQSWVCDGNNDCGDNS 2903

  Fly   329 DEKECPVVPCDSVAEHTCTNG------------ACIAKRWVCDGDPDCSDGSDE-RSCANVTKTT 380
            ||.:  .:.|.|   .||..|            .||...:||||:.||.|.:|| .:|.|.|   
Zfish  2904 DEAQ--ELQCGS---RTCNPGDFTCPSWYPGSPRCIPLSYVCDGEKDCVDAADELHNCPNRT--- 2960

  Fly   381 TPCLSHEYQCKDRITCLHHSWLCDGDRDCPDGDDEHTANCKNVTCRADQFQCGDRSCIPGHLTCN 445
              |..:|:.|.:. .|:...:.||...||.||.||  .||...||.:.:|.|.:..|||....|:
Zfish  2961 --CHLNEFACANG-RCILLPFHCDRVNDCGDGSDE--TNCIYNTCSSREFTCQNGVCIPSTYVCD 3020

  Fly   446 GDKDCADGSDERDCGLSLSLGINQGGCN------ATSEFDCGGGQCVPLSKVCDKRKDCPDGEDE 504
            |..||.|||||.           :|.|.      |..:|.|..|:|:.:.|||::::||.|..||
Zfish  3021 GYIDCQDGSDEL-----------EGLCRTPEPTCAPGDFMCNSGECIDIHKVCNQQRDCSDNSDE 3074

  Fly   505 PAGKCGINECASKN-GGCMHQCIDLKVGHHCECHEGYKLSPDKRNCQDINEC-EVPGKCSQICVN 567
            ..  ||||||.:.. ..|.|.|||.:.|::|.|.|||:|.||.:.|:||:|| ||||.|||:|.|
Zfish  3075 KG--CGINECTNPAIHQCAHNCIDTQTGYYCSCREGYRLMPDGKACEDIDECKEVPGVCSQVCEN 3137

  Fly   568 EIGGFKCECEAGYMRDPKNHTRCKASEGHAS-LLLARRHDIRKIALDHMEMTSIVNSTKAATALD 631
            .:|.|.|:|..||:|:|...| |:.:.|.|. ||.:.|:.||.:......|:.::.......|||
Zfish  3138 AVGSFYCKCAPGYLREPDGRT-CRQNSGIAPYLLYSNRYYIRNLTAVGSSMSVVLQGLTNVVALD 3201

  Fly   632 FVFRTGMIFWSDVTTQSIYKAPIDEGNEKTVVLTKSSVTSDGLAVDWIYNHVYFTDTHKCTIELT 696
            |......::|.||.|..|.:..:| |..:.|::......::||||||:...:|:.|.....|.::
Zfish  3202 FDTTEKRLYWVDVGTLRIERINLD-GTGREVIMQNDLGGAEGLAVDWVGRKLYWADATMKAIHVS 3265

  Fly   697 NFEGSMGKVLVKDSLDI--------PRSIALDPIEGWMYWSDWGASPRIERAGMDGSHRTTIISY 753
            ..:|...|.|:||.:|.        |:::|::|..||:||:|||....|.||||||:..:.:|:.
Zfish  3266 ELDGRYRKKLLKDCVDTNSTYCFASPQAVAVNPKYGWLYWTDWGRKAFIGRAGMDGTQASALITT 3330

  Fly   754 DVKWPNGITLDLVKKRIYWVDGKLNVISSANYDGSQRSQVLYSGEYLRHPFSITTFEDNVYWTDW 818
            .:.||:.:|:|....:|::.|..||.:..|:.||..|.:.:...  |.|.:::|.|||.||||||
Zfish  3331 KLVWPHALTIDYTNNKIFFADAHLNFLDYADMDGQNRHRAITGS--LPHAYALTLFEDLVYWTDW 3393

  Fly   819 DKQAVFKANKFTGEDVEPVTAMHMLQHPMVVHVYHPYRQPDGVNHCQSVNGH---CSHLCLPAPR 880
            :...:.:|:|:||  ...|...:....|..:|:|||||||...|.|   |.|   ||||||..|.
Zfish  3394 NTHTIERAHKYTG--ANRVVMGNNTHRPNDIHIYHPYRQPHSENPC---NDHYLTCSHLCLIGPG 3453

  Fly   881 INERSPRISCACP-------TGLKLMVDGLMCVED---------------PLYL----------- 912
            ..|    ..|.||       .|.|     :.||.|               |::.           
Zfish  3454 GTE----ARCECPDHFIGLAIGFK-----IQCVADCSSTQFRCGDNEKCIPIWWKCDGQSDCGDG 3509

  Fly   913 --PPVTRPPRARKT 924
              .|.|.||...||
Zfish  3510 SDEPQTCPPHYCKT 3523

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LpR1NP_001097934.2 LDLa 135..167 CDD:197566 14/31 (45%)
LDLa 178..210 CDD:197566 15/31 (48%)
LDLa 219..254 CDD:238060 19/41 (46%)
LDLa 259..295 CDD:238060 18/36 (50%)
LDLa 343..373 CDD:238060 14/42 (33%)
LDLa 383..415 CDD:197566 10/31 (32%)
Ldl_recept_a 423..459 CDD:278486 16/35 (46%)
LDLa 476..504 CDD:197566 10/27 (37%)
FXa_inhibition 514..549 CDD:291342 15/35 (43%)
EGF_CA 551..581 CDD:214542 18/30 (60%)
LY 662..702 CDD:214531 11/39 (28%)
LY 704..747 CDD:214531 22/50 (44%)
LY 749..790 CDD:214531 12/40 (30%)
FXa_inhibition 864..905 CDD:291342 16/50 (32%)
lrp2bXP_021335953.1 LDLa 2..34 CDD:238060
LDLa 38..71 CDD:197566
LDLa 80..114 CDD:238060
LDLa 123..151 CDD:238060
LDLa 155..189 CDD:238060
LDLa 194..228 CDD:238060
LDLa 235..269 CDD:238060
FXa_inhibition 324..>347 CDD:317114
LY 429..469 CDD:214531
LY 471..516 CDD:214531
LY 519..559 CDD:214531
FXa_inhibition 631..672 CDD:317114
Ldl_recept_b 808..848 CDD:278487
LY 834..874 CDD:214531
FXa_inhibition 950..982 CDD:317114
LDLa 995..1029 CDD:238060
LDLa 1036..1070 CDD:238060
LDLa 1078..1112 CDD:238060
LDLa 1119..1153 CDD:238060
LDLa 1157..1192 CDD:238060
LDLa 1200..1234 CDD:238060
LDLa 1241..1275 CDD:238060
LDLa 1282..1314 CDD:197566
FXa_inhibition 1323..1358 CDD:317114
EGF_CA 1360..1398 CDD:214542
YncE 1388..>1660 CDD:331368
LY 1470..1512 CDD:214531
Ldl_recept_b 1535..1575 CDD:278487
LY 1559..1601 CDD:214531
LY 1789..1824 CDD:214531
LY 1837..1879 CDD:214531
LY 1922..1958 CDD:214531
FXa_inhibition 1991..2027 CDD:317114
Ldl_recept_b 2170..2210 CDD:278487
LY 2195..2236 CDD:214531
LY 2427..2468 CDD:214531
LY 2468..2510 CDD:214531
LY 2513..2553 CDD:214531
FXa_inhibition 2623..2660 CDD:317114 8/39 (21%)
LDLa 2667..2699 CDD:197566 14/31 (45%)
LDLa 2709..2743 CDD:238060 16/33 (48%)
LDLa 2750..2785 CDD:238060 4/34 (12%)
LDLa 2789..2822 CDD:197566 15/32 (47%)
LDLa 2831..2863 CDD:197566 17/33 (52%)
LDLa 2873..2905 CDD:197566 17/31 (55%)
LDLa 2915..2952 CDD:197566 12/36 (33%)
LDLa 2961..2995 CDD:238060 12/36 (33%)
LDLa 2999..3031 CDD:197566 14/31 (45%)
Ldl_recept_a 3042..3077 CDD:278486 13/36 (36%)
cEGF 3100..3123 CDD:315355 12/22 (55%)
vWFA <3115..3158 CDD:320736 22/42 (52%)
LY 3189..3229 CDD:214531 11/40 (28%)
LY 3230..3272 CDD:214531 11/41 (27%)
Ldl_recept_b 3303..3341 CDD:278487 16/37 (43%)
LY 3327..3367 CDD:214531 12/39 (31%)
LY 3374..3409 CDD:214531 16/38 (42%)
LDLa 3480..3512 CDD:197566 1/31 (3%)
LDLa 3521..3552 CDD:197566 2/3 (67%)
LDLa 3561..3593 CDD:197566
LDLa 3602..3634 CDD:197566
LDLa 3646..3682 CDD:238060
LDLa 3689..3722 CDD:238060
LDLa 3727..3761 CDD:238060
LDLa 3766..3800 CDD:238060
LDLa 3810..3841 CDD:197566
LDLa 3854..3883 CDD:197566
LDLa 3896..3930 CDD:238060
EGF_CA 3975..4014 CDD:214542
LY 4107..4142 CDD:214531
LY 4143..4186 CDD:214531
LY 4187..4230 CDD:214531
FXa_inhibition 4306..>4324 CDD:317114
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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