DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LpR1 and ldlr

DIOPT Version :9

Sequence 1:	NP_001097934.2	Gene:	LpR1 / 2768687	FlyBaseID:	FBgn0066101	Length:	1076	Species:	Drosophila melanogaster
Sequence 2:	XP_002942891.1	Gene:	ldlr / 100495826	XenbaseID:	XB-GENE-962372	Length:	894	Species:	Xenopus tropicalis

Alignment Length:	931	Identity:	357/931 - (38%)
Similarity:	490/931 - (52%)	Gaps:	112/931 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 CSSDQFRCGNGNCIPNKWRCDQESDCADGSDEANELCMNACPNNEFKCQTVDQCIPRSWLCDGSN 243
            |...:|:||:|.|||.||.||..::|.|||||:.|.
Frog    29 CDRSEFQCGDGKCIPYKWICDGSAECKDGSDESPET----------------------------- 64

  Fly   244 DCRDKSDEAHCRARTCSPDEYACKSGEGQCVPLAWMCDQSKDCSDGSDEHNC-NQTCRADEFTCG 307
                      |:..||..|.::|.....:|:||.|.||...||.:||||::| .:.|..|:|||.
Frog    65 ----------CKVVTCGADHFSCGGRLNRCIPLLWKCDGQTDCENGSDENDCTRKVCADDQFTCR 119

  Fly   308 NGRCIQKRWKCDHDDDCGDGSDEKECPVVPCDSVAEHTCTNGACIAKRWVCDGDPDCSDGSDERS 372
            :|:||...:.||.|.||.|||||..||...|:.........|.||.|.|.|||||||.|||||:.
Frog   120 SGKCISLDFVCDEDLDCDDGSDESYCPAPTCNPAMFQCKDKGICIPKLWACDGDPDCEDGSDEQH 184

  Fly   373 C--ANVTKTTTPCLSHEYQCKDRITCLHHSWLCDGDRDCPDGDDEHTANCKNVTCRADQFQCGDR 435
            |  ....||..||...|:.|... .|:|.||.|||..||.|..||  .:|...|||.|:|||.|.
Frog   185 CEGREPIKTDKPCSPLEFHCGSG-ECIHMSWKCDGGYDCKDKSDE--KDCVKPTCRPDEFQCNDG 246

  Fly   436 SCIPGHLTCNGDKDCADGSDERDCGLSLSLGINQGGCNATSEFDCGGGQCVPLSKVCDKRKDCPD 500
            :||.|...|:.:.||.|.|||..|       :|...|.....|.|..|:|:.:.|||:|::||.|
Frog   247 TCIHGSRQCDREYDCKDLSDEEGC-------VNVTKCEGPDVFKCRSGECITMDKVCNKKRDCRD 304

  Fly   501 GEDEPAGKCGINECASKNGGCMHQCIDLKVGHHCECHEGYKLSPDKRNCQDINECEVPGKCSQIC 565
            ..|||..:||.|||...||||.|.|.|||:|:.|.|:|||:| .||:.|:||||||.|..|||||
Frog   305 WSDEPIKECGENECMRNNGGCAHICNDLKIGYECLCNEGYRL-VDKKRCEDINECENPNTCSQIC 368

  Fly   566 VNEIGGFKCECEAGYMRDPKNHTRCKASEGHASLLLARRHDIRKIALDHMEMTSIVNSTKAATAL 630
            :|..||:||||..||..||.. ..||:....|.|....||::||:.||..|.||.:...|...||
Frog   369 INLDGGYKCECREGYQMDPVT-ASCKSIGTVAYLFFTNRHEVRKMTLDRSEYTSFIPRLKNVVAL 432

  Fly   631 DFVFRTGMIFWSDVTTQSIYKAPIDEGNEKT---VVLTKSSVTSDGLAVDWIYNHVYFTDTHKCT 692
            |....:..|:|||:|.:.||.|.:|:.:..:   .|::......||:|||||:.::|:||:...|
Frog   433 DMEIASNKIYWSDLTQRKIYSASMDKADNTSHHETVISSQIQAPDGIAVDWIHGNIYWTDSKFST 497

  Fly   693 IELTNFEGSMGKVLVKDSLDIPRSIALDPIEGWMYWSDWGASPRIERAGMDGSHRTTIISYDVKW 757
            |.:.|.|||..|.|..|.|..||.|.:||.:|:|||:|||...:||:.|::|..|..:::.:::|
Frog   498 ISVANTEGSKRKTLFSDDLAKPRDIVVDPSQGFMYWTDWGLPAKIEKGGLNGVDRYPLVTENIEW 562

  Fly   758 PNGITLDLVKKRIYWVDGKLNVISSANYDGSQRSQVLYSGEYLRHPFSITTFEDNVYWTDWDKQA 822
            ||||||||..:|:||||.||:.:|..:..|..|..|:....:|.|||.:|.|||.|:|||.:.:|
Frog   563 PNGITLDLTNQRLYWVDSKLHSLSCIDVTGQNRITVISDETHLAHPFGLTVFEDLVFWTDIENEA 627

  Fly   823 VFKANKFTGEDVEPVTAMHMLQHPMVVHVYHPYRQPDGVNHCQS---VNGHCSHLCLPAPRINER 884
            :|.||:.||.::..|.  ..|..|..:.:||..|||...|.|:|   .||.|.:||||||.|..|
Frog   628 IFSANRLTGSNITKVA--EDLLSPEDIVLYHNLRQPKAENWCESHHLGNGGCEYLCLPAPLITSR 690

  Fly   885 SPRISCACPTGLKLMVDGLMCVEDPLYLP-----PVTRPPRARKTKPRPKSPRRRLPTGVQVGHA 944
            ||:.:||||.|:.|..|...||::|: ||     ..|..|....|..||.:   |..|..::
Frog   691 SPKFTCACPDGMHLGADMRSCVKEPV-LPETSTTTTTSAPVTTTTTTRPTT---RSTTLAKI--- 748

  Fly   945 DIRIEINDDLQLSTRLPLLPTTFVADQRPVKNHTQIEKTT---TPSEQPDSGFIALVVIASLSG- 1005
                 .:....::.:.|.:.:|.||..||.   |:..|||   .....||......|..:.|:|
Frog   749 -----TSTTSTVAPQRPKMASTTVAPPRPT---TESPKTTQRMVTERVPDRTTWEPVTHSQLAGN 805

  Fly  1006 -FA----------------VLLSVLLLI-----GYRYCSKRRI---NSMNFENPIYRKTTTTEDH 1045
             ||                ::|.:::|.     |:......|:   ||:||:||:|:| ||.||.
Frog   806 KFANEGVVESARSHPTALYIVLPIVILCLVAFGGFLLWKNWRLKNTNSINFDNPVYQK-TTEEDQ 869

  Fly  1046 FSLRKNLPARIYDHTSVMDEE 1066
            ..:.::.....|....::..|
Frog   870 IHIGRSQDGYTYPSRQMVSLE 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LpR1	NP_001097934.2	LDLa	135..167	CDD:197566
		LDLa	178..210	CDD:197566	16/30 (53%)
		LDLa	219..254	CDD:238060	0/34 (0%)
		LDLa	259..295	CDD:238060	15/35 (43%)
		LDLa	343..373	CDD:238060	17/29 (59%)
		LDLa	383..415	CDD:197566	13/31 (42%)
		Ldl_recept_a	423..459	CDD:278486	18/35 (51%)
		LDLa	476..504	CDD:197566	11/27 (41%)
		FXa_inhibition	514..549	CDD:291342	19/34 (56%)
		EGF_CA	551..581	CDD:214542	20/29 (69%)
		LY	662..702	CDD:214531	16/39 (41%)
		LY	704..747	CDD:214531	20/42 (48%)
		LY	749..790	CDD:214531	18/40 (45%)
		FXa_inhibition	864..905	CDD:291342	22/43 (51%)
ldlr	XP_002942891.1	Ldl_recept_a	27..60	CDD:365841	16/30 (53%)
		Ldl_recept_a	68..106	CDD:365841	16/37 (43%)
		LDLa	111..145	CDD:238060	18/33 (55%)
		Ldl_recept_a	149..185	CDD:365841	18/35 (51%)
		Ldl_recept_a	195..231	CDD:365841	16/38 (42%)
		Ldl_recept_a	235..270	CDD:365841	18/34 (53%)
		LDLa	278..308	CDD:381805	11/29 (38%)
		FXa_inhibition	318..352	CDD:373209	19/34 (56%)
		EGF_CA	354..384	CDD:214542	20/29 (69%)
		LY	419..457	CDD:214531	14/37 (38%)
		Ldl_recept_b	439..482	CDD:278487	13/42 (31%)
		Ldl_recept_b	486..525	CDD:278487	16/38 (42%)
		Ldl_recept_b	529..569	CDD:278487	18/39 (46%)
		LY	555..595	CDD:214531	18/39 (46%)
		Ldl_recept_b	616..655	CDD:278487	14/40 (35%)
		FXa_inhibition	674..711	CDD:373209	20/36 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	58	1.000	Domainoid score	I10588
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	700	1.000	Inparanoid score	I657
OMA	1	1.010	-	-		QHG49125
OrthoDB	1	1.010	-	-		D179614at33208
OrthoFinder	1	1.000	-	-		FOG0002088
OrthoInspector	1	1.000	-	-		mtm9446
Panther	1	1.100	-	-	O	PTHR24270
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1052
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.080