DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LpR1 and lrp8

DIOPT Version :9

Sequence 1:	NP_001097934.2	Gene:	LpR1 / 2768687	FlyBaseID:	FBgn0066101	Length:	1076	Species:	Drosophila melanogaster
Sequence 2:	XP_004914072.1	Gene:	lrp8 / 100489827	XenbaseID:	XB-GENE-980035	Length:	936	Species:	Xenopus tropicalis

Alignment Length:	975	Identity:	362/975 - (37%)
Similarity:	520/975 - (53%)	Gaps:	107/975 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 IGTPLGIGQSLEAKCDEKQFQCHSGDCIPIRFVCDGDADCKDHSDEQIKECKFIEATCSSDQFRC 186
            :||..|.|.: .:.|:|.||||.:..|||..:.||.|.||.|:|||.  :|.  :.||..|:|.|
Frog    19 LGTRGGRGPT-TSDCEEGQFQCRNQRCIPSVWRCDEDDDCADNSDED--DCP--KTTCGEDEFTC 78

  Fly   187 GNGNCIPNKWRCDQESDCADGSDEANELCMNACPNNEFKCQTVDQCIPRSWLCDGSNDCRDKSDE 251
            .:|:||..:|:||.|.:|.|.|||:...|.:|
Frog    79 NSGHCISARWKCDGEEECPDKSDESEATCSSA--------------------------------- 110

  Fly   252 AHCRARTCSPDEYACKSGEGQCVPLAWMCDQSKDCSDGSDEHNCNQTCRADEFTCGNGRCIQKRW 316
                .:.|:..:::|.....:|:|::|.||..:||.:|.||.:|..:|...||.|.|..|:...:
Frog   111 ----KQVCAAQKFSCGGPSNKCIPVSWRCDGERDCENGLDEKDCPTSCTPGEFQCNNKTCLASVF 171

  Fly   317 KCDHDDDCGDGSDEKECPVVPCDSVAEHTCTNGACIAKRWVCDGDPDCSDGSDERS--CA--NVT 377
            .||..::|||||||:.|..:.| ...|..|.|..||.::|:|||.|||.|.|||..  |.  |..
Frog   172 VCDGVNNCGDGSDERGCLPITC-KPGEFRCGNNECILEKWLCDGQPDCDDQSDESEAHCGLKNQP 235

  Fly   378 KTTTPCLSHEYQCKDRITCLHHSWLCDGDRDCPDGDDEHTANCKNVTCRADQFQCGDRSCIPGHL 442
            :..|.|..||::|.:. .|:..:|.||||.||.|..||  .:|...|||.|:|||||.||:.|..
Frog   236 QAITQCGEHEFRCNNG-NCILLNWRCDGDEDCKDKSDE--MDCHLATCRPDEFQCGDGSCVHGMK 297

  Fly   443 TCNGDKDCADGSDERDCGLSLSLGINQGGCNATSEFDCGGGQCVPLSKVCDKRKDCPDGEDEPAG 507
            .|||.:||.|.|||..|..:.|      .|.....|.|..|:|:..:||||..:||.|..||...
Frog   298 QCNGVRDCLDSSDEAGCQSAHS------PCEGDGRFQCKSGECIDSTKVCDGNRDCRDWSDESLT 356

  Fly   508 KCGINECASKNGGCMHQCIDLKVGHHCECHEGYKLSPDKRNCQDINECEVPGKCSQICVNEIGGF 572
            .|.||||...||||.|.|.|||||:.|:|..||||. ||:.|.||:|||.|..|||||||..|.|
Frog   357 ACDINECMVNNGGCSHICRDLKVGYECDCPVGYKLM-DKKTCGDIDECENPDACSQICVNYKGDF 420

  Fly   573 KCECEAGYMRDPKNHTRCKASEGHASLLLARRHDIRKIALDHMEMTSIVNSTKAATALDFVFRTG 637
            ||||..||..|..:.| |||...:..|:...||::|:|.:.|.:.:.:....|...:||....:.
Frog   421 KCECYEGYEMDSVSKT-CKAVGQNPYLIFTNRHELRQIDIVHRDYSRLAAQLKNVVSLDVEVTSR 484

  Fly   638 MIFWSDVTTQSIYKAPID---EGNEKTVVLTKSSVTSDGLAVDWIYNHVYFTDTHKCTIELTNFE 699
            ||:|.|:..:.||.||:|   :.:|..|::..:..:.:|||:|||:.::|:||:...||.:...:
Frog   485 MIYWCDLYYRRIYSAPLDRAADPSEHVVIINTTLHSPEGLAIDWIHKNIYWTDSGNKTISVATAD 549

  Fly   700 GSMGKVLVKDSLDIPRSIALDPIEGWMYWSDWGASPRIERAGMDGSHRTTIISYDVKWPNGITLD 764
            |...|.|.::.|..||:||:||::|:|:|||||...:||:||::|..|..::|.:::||||||||
Frog   550 GCKRKTLFRNGLGEPRAIAVDPVQGFMFWSDWGDPAKIEKAGLNGGDRQVLVSDNIEWPNGITLD 614

  Fly   765 LVKKRIYWVDGKLNVISSANYDGSQRSQVLYSGEYLRHPFSITTFEDNVYWTDWDKQAVFKANKF 829
            ::..|:||||.||:.:||.:::|..|..::.|.:.|.|||.:..|||.::|||.:.:|:|.||:.
Frog   615 VLGCRLYWVDSKLHTLSSVDFNGFNRKLLISSEDSLSHPFGLAVFEDKIFWTDLENEAIFSANRL 679

  Fly   830 TGEDVEPVTAMHMLQHPMVVHVYHPYRQPDGVNHCQS---VNGHCSHLCLPAPRINERSPRISCA 891
            ||.::..:.  ..|.:|..:.|.|..:||..||.|..   .||.|.:||||||:|:..||:.:||
Frog   680 TGHEISILA--DNLNNPHDIVVVHQLKQPKAVNACNQGSLPNGGCEYLCLPAPQISAHSPKYTCA 742

  Fly   892 CPTGLKLMVDGLMC----VEDPLYLPPVTRP---PRARKTKPRPKSPRRRLPTG---VQVGHADI 946
            ||.|:.|..|...|    |.....|..||..   |.|..|.....|   .|||.   .....|..
Frog   743 CPDGIALGPDMRSCEKVTVATSKPLADVTNAIHHPEASTTAEMTTS---ALPTSSYTTTTTAATT 804

  Fly   947 RIEINDDLQLSTRLPLLPTTFVADQRPVKN----HTQIEKTTTPSEQPDSGFIALVVIASLSGFA 1007
            .|.:|.....:|.    ..:.::..|..:|    ::.:..|...|:...|..:...||    |.|
Frog   805 EISLNYSSLTNTH----QNSSLSRDRDARNKNTGNSSLSLTYGNSDSDLSSTLTAAVI----GVA 861

  Fly  1008 V---LLSVLLLIGY---RYCSKRRINSMNFENPIYRKTTTTED------HFSLRKNL----PARI 1056
            |   :|::|.|:||   |...::...||||:||:|||||..|:      |......:    |||:
Frog   862 VPLAVLALLCLLGYLIWRNWKRKNTKSMNFDNPVYRKTTEDEEEEEDEIHIGRTAQIGHVYPARV 926

Fly 1057 1056
Frog 927 926

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LpR1	NP_001097934.2	LDLa	135..167	CDD:197566	16/31 (52%)
		LDLa	178..210	CDD:197566	15/31 (48%)
		LDLa	219..254	CDD:238060	0/34 (0%)
		LDLa	259..295	CDD:238060	12/35 (34%)
		LDLa	343..373	CDD:238060	16/31 (52%)
		LDLa	383..415	CDD:197566	13/31 (42%)
		Ldl_recept_a	423..459	CDD:278486	21/35 (60%)
		LDLa	476..504	CDD:197566	11/27 (41%)
		FXa_inhibition	514..549	CDD:291342	20/34 (59%)
		EGF_CA	551..581	CDD:214542	20/29 (69%)
		LY	662..702	CDD:214531	13/39 (33%)
		LY	704..747	CDD:214531	21/42 (50%)
		LY	749..790	CDD:214531	19/40 (48%)
		FXa_inhibition	864..905	CDD:291342	20/43 (47%)
lrp8	XP_004914072.1	LDLa	32..66	CDD:238060	18/35 (51%)
		LDLa	70..102	CDD:197566	15/31 (48%)
		Ldl_recept_a	114..150	CDD:365841	12/35 (34%)
		LDLa	154..188	CDD:238060	15/33 (45%)
		LDLa	192..224	CDD:197566	15/32 (47%)
		LDLa	241..275	CDD:238060	15/36 (42%)
		Ldl_recept_a	279..314	CDD:365841	21/34 (62%)
		LDLa	323..353	CDD:238060	11/29 (38%)
		FXa_inhibition	363..397	CDD:373209	20/34 (59%)
		EGF_CA	399..429	CDD:214542	20/29 (69%)
		LY	467..502	CDD:214531	11/34 (32%)
		LY	512..553	CDD:214531	13/40 (33%)
		Ldl_recept_b	574..614	CDD:278487	20/39 (51%)
		LY	598..640	CDD:214531	19/41 (46%)
		Ldl_recept_b	661..699	CDD:278487	12/39 (31%)
		FXa_inhibition	719..756	CDD:373209	19/36 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	53	1.000	Domainoid score	I11165
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	700	1.000	Inparanoid score	I657
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D179614at33208
OrthoFinder	1	1.000	-	-		FOG0002088
OrthoInspector	1	1.000	-	-		mtm9446
Panther	1	1.100	-	-	O	PTHR24270
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1052
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160