DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mld and ZNF585B

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_689492.3	Gene:	ZNF585B / 92285	HGNCID:	30948	Length:	769	Species:	Homo sapiens

Alignment Length:	1022	Identity:	181/1022 - (17%)
Similarity:	304/1022 - (29%)	Gaps:	384/1022 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   995 AADTQPQNESA----NH-SPFESPISSPQVQSQIELQMEPQIETQMQPQIETRMQHDVLSVQSPQ 1054
            |:.|.||..||    :| |.:|..:|...|  .|:...|   |.:.....:..:..||:.
Human     3 ASWTSPQKSSALAPEDHGSSYEGSVSFRDV--AIDFSRE---EWRHLDLSQRNLYRDVML----- 57

  Fly  1055 NHQPQVQSHDQSQMQHQIPPQIEPQIEVQNQEQNTLQLVPQAQHQVVPHVQLQSQLVPHVQTQGT 1119
                :..||..| :.:|:|   :|::.:..|.:....|..:......|..:|..
Human    58 ----ETYSHLLS-VGYQVP---KPEVVMLEQGKEPWALQGERPRHSCPGEKLWD----------- 103

  Fly  1120 TTTVTYEQIYQQHIVQQTVQQSSNKMQVISLPSAGSETTRQWQTQQSQQ----QQQVQWSSVGGL 1180
                     :.||            .::|....|.|:..:.:..::|.:    .:...|.|
Human   104 ---------HNQH------------RKIIGYKPASSQDQKIYSGEKSYECAEFGKSFTWKS---- 143

  Fly  1181 EAIKSAPVESVAPTTTTYY--ISASDLYPQQTETYTMLQPASNESYVIEQVNHQQQHCQQQ---- 1239
                ...|....||....|  |.....:.|:.|..|                ||:.|.:::
Human   144 ----QFKVHLKVPTGEKLYVCIECGRAFVQKPEFIT----------------HQKTHMREKPYKC 188

  Fly  1240 -------IQMSQQ-QHQRQHQQQQAQQQQQPIMILIQQPEIQQPVASASNPQQAPLHIYNAATSN 1296
                   .|:|.. :|.|.|..::..:..:               .....|..:.|.|:....:.
Human   189 NECGKSFFQVSSLFRHHRIHTGEKLYECSE---------------CGKGFPYNSDLSIHEKIHTG 238

  Fly  1297 D-------------------VHQMQHTQRQ------------QIRQQYQHQQYQRLQQPQQTR-- 1328
            :                   :||..||..:            |..|...|::....::|.:..
Human   239 ERHHECTDCGKAFTQKSTLKIHQKIHTGERSYICIECGQAFIQKTQLIAHRRIHSGEKPYECNNC 303

  Fly  1329 --------VVQSHPVLGMPGATSISTKVTPIPVT----------------AARGRPLTLKCRFCH 1369
                    .:|.|        ..:.|:|.|...|                ..:.|..:..|..|.
Human   304 GKSFISKSQLQVH--------QRVHTRVKPYICTEYGKVFSNNSNLITHEKIQSREKSSICTECG 360

  Fly  1370 NGPRFSSSLEYSRHIIDLHPAVAPFNCPHCPMAFAGRTK------------------------RS 1410
            ....:.|.|...:.|   |....|:.|..|..||..::.                        |.
Human   361 KAFTYRSELIIHQRI---HTGEKPYECSDCGRAFTQKSALTVHQRIHTGEKSYICMKCGLAFIRK 422

  Fly  1411 QHILSHHVV----QQYQCGQCSHVFPAQKALDVHIQRFHMTLKTDPSGAVKVEDVQLQITSER-- 1469
            .|:::|.::    :.|:||.|..:|.::..|.|| :|.|                    |.|:
Human   423 AHLITHQIIHTGEKPYKCGHCGKLFTSKSQLHVH-KRIH--------------------TGEKPY 466

  Fly  1470 --RPRGRPYKPRLQLQQHQLQPQQKLQVQQHQQQQ--------KALQQLPQAQHHQQQQQPQLQQ 1524
              ...|:.:..|..|..||         :.|..::        ||..|......||:....:...
Human   467 VCNKCGKAFTNRSNLITHQ---------KTHTGEKSYICSKCGKAFTQRSDLITHQRIHTGEKPY 522

  Fly  1525 E------VLQQVQQLQVQVQPQQHQQHQQVLQVQQPQQQPLMQPQSPHPSTVEMQASPTTPRKIL 1583
            |      ...|...|.:         ||::                   .|.|.|.
Human   523 ECNTCGKAFTQKSNLNI---------HQKI-------------------HTGERQY--------- 550

  Fly  1584 CCPDCEDCTSGHSHANEQFEELQTLQAPPTVLTPPSTIVSVPSPQPMVYSQHITMPSPEQSEPDS 1648
               :|.:|       .:.|.:...|.....:.|.....|.....:..:
Human   551 ---ECHEC-------GKAFNQKSILIVHQKIHTGEKPYVCTECGRAFI----------------- 588

  Fly  1649 TTTLRQYRKRGVIVGPQGPLHLATPVASPSPSSSPSSSTVDHIPPASPATPASPAPPPSPAVAST 1713
                   ||...|...:  :|                            |...|
Human   589 -------RKSNFITHQR--IH----------------------------TGEKP----------- 605

  Fly  1714 VQVSELRTSHHCLYCEERFTNEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHMESHDV 1778
                     :.|..|.:.||::..|..|..:..|   ..||||..|.:.:..|:.|.:|.::|..
Human   606 ---------YECSDCGKSFTSKSQLLVHQPVHTG---EKPYVCAECGKAFSGRSNLSKHQKTHTG 658

  Fly  1779 EGRPYECNICRVRFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH-GELGYQCD 1842
            | :||.|:.|...|.:.|:|..|. .:|...||:.|.:|||.|..:|.|:.|.:.| ||..|.|.
Human   659 E-KPYICSECGKTFRQKSELITHH-RIHTGEKPYECSDCGKSFTKKSQLQVHQRIHTGEKPYVCA 721

  Fly  1843 GCDRTFEYLKELRKHRRTHS-EMFYKCKFCPSSFMRFTNFRAHMKTH 1888
            .|.:.|.....|.||:.||: :..|||..|...|::.:.|..|..:|
Human   722 ECGKAFSNRSNLNKHQTTHTGDKPYKCGICGKGFVQKSVFSVHQSSH 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	5/22 (23%)
		C2H2 Zn finger	1396..1416	CDD:275368	6/43 (14%)
		C2H2 Zn finger	1424..1445	CDD:275368	8/20 (40%)
		C2H2 Zn finger	1725..1746	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1756..1776	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1785..1806	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1814..1834	CDD:275368	8/19 (42%)
		zf-C2H2	1839..1861	CDD:278523	7/21 (33%)
		C2H2 Zn finger	1841..1861	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1868..1888	CDD:275368	5/19 (26%)
ZNF585B	NP_689492.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24		8/20 (40%)
		KRAB	27..85	CDD:214630	14/75 (19%)
		KRAB	27..66	CDD:279668	10/53 (19%)
		C2H2 Zn finger	132..152	CDD:275368	3/27 (11%)
		COG5048	156..529	CDD:227381	69/444 (16%)
		C2H2 Zn finger	160..180	CDD:275368	6/35 (17%)
		C2H2 Zn finger	188..208	CDD:275368	4/19 (21%)
		C2H2 Zn finger	216..236	CDD:275368	3/34 (9%)
		zf-H2C2_2	228..253	CDD:290200	2/24 (8%)
		C2H2 Zn finger	244..264	CDD:275368	2/19 (11%)
		C2H2 Zn finger	272..292	CDD:275368	3/19 (16%)
		C2H2 Zn finger	300..320	CDD:275368	2/27 (7%)
		C2H2 Zn finger	328..347	CDD:275368	1/18 (6%)
		COG5048	335..768	CDD:227381	113/591 (19%)
		C2H2 Zn finger	356..376	CDD:275368	5/22 (23%)
		zf-H2C2_2	368..393	CDD:290200	8/27 (30%)
		C2H2 Zn finger	384..404	CDD:275368	4/19 (21%)
		C2H2 Zn finger	412..432	CDD:275368	3/19 (16%)
		zf-H2C2_2	424..449	CDD:290200	7/24 (29%)
		C2H2 Zn finger	440..460	CDD:275368	8/20 (40%)
		zf-H2C2_2	455..477	CDD:290200	7/42 (17%)
		C2H2 Zn finger	468..488	CDD:275368	5/28 (18%)
		C2H2 Zn finger	496..516	CDD:275368	5/19 (26%)
		zf-H2C2_2	508..533	CDD:290200	3/24 (13%)
		C2H2 Zn finger	524..544	CDD:275368	4/47 (9%)
		zf-H2C2_2	536..561	CDD:290200	9/71 (13%)
		C2H2 Zn finger	552..572	CDD:275368	4/26 (15%)
		zf-H2C2_2	565..589	CDD:290200	3/47 (6%)
		C2H2 Zn finger	580..600	CDD:275368	3/45 (7%)
		zf-H2C2_2	592..617	CDD:290200	7/74 (9%)
		C2H2 Zn finger	608..628	CDD:275368	6/19 (32%)
		C2H2 Zn finger	636..656	CDD:275368	5/19 (26%)
		zf-H2C2_2	648..673	CDD:290200	9/25 (36%)
		C2H2 Zn finger	664..684	CDD:275368	6/20 (30%)
		zf-H2C2_2	676..700	CDD:290200	9/24 (38%)
		C2H2 Zn finger	692..712	CDD:275368	8/19 (42%)
		zf-H2C2_2	705..729	CDD:290200	9/23 (39%)
		C2H2 Zn finger	720..740	CDD:275368	6/19 (32%)
		zf-H2C2_2	732..757	CDD:290200	10/24 (42%)
		C2H2 Zn finger	748..768	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100