DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mld and ZNF845

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_001308451.1	Gene:	ZNF845 / 91664	HGNCID:	25112	Length:	970	Species:	Homo sapiens

Alignment Length:	583	Identity:	131/583 - (22%)
Similarity:	208/583 - (35%)	Gaps:	171/583 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1364 KCRFCHNGPRFS--SSLEYSRHIIDLHPAVAPFNCPHCPMAFAGRTKRSQHILSHHVVQQYQCGQ 1426
            ||..|  |..||  |.|.|.|.   ||....|:.|..|..||:.::...:|...|...:.|:|.:
Human   328 KCNEC--GKTFSQTSYLVYHRR---LHTGEKPYKCEECDKAFSFKSNLERHRKIHTGEKPYKCNE 387

  Fly  1427 CSHVFPAQKALDVHIQRFHMTLKTDPSGAVKVEDVQLQITSERRPRGRPYKPRLQLQQHQLQPQQ 1491
            ||..|..:.:|..| :|.|                    |.|     :|||
Human   388 CSRTFSRKSSLTRH-RRLH--------------------TGE-----KPYK-------------- 412

  Fly  1492 KLQVQQHQQQQKALQQLPQAQHHQQ---QQQPQLQQEVLQQVQQLQVQVQPQQHQQHQQVLQVQQ 1553
                  .....|...|:....:|::   .::|...:| ..:....:..:     ::|:::...::
Human   413 ------CNDCGKTFSQMSSLVYHRRLHTGEKPYKCEE-CDEAFSFKSNL-----ERHRRIHTGEK 465

  Fly  1554 P-----------QQQPLMQPQSPHPSTVEMQASPTTPRKILCCPDCEDCTSGHS--------HAN 1599
            |           |...|:..:..|           |..|...|.:|::..|..|        |..
Human   466 PYKCNDCGKTFSQTSSLVYHRRLH-----------TGEKPYKCEECDEAFSFKSNLERHRIIHTG 519

  Fly  1600 EQF---EELQTLQAPPTVLTPPSTIVSVPSP-------------QPMVYSQHI-------TMPSP 1641
            |:.   .|.....:..:.||....:.:...|             ..::|.|.|       .....
Human   520 EKLYKCNECGKTFSRKSSLTRHCRLHTGEKPYQCNECGKAFRGQSALIYHQAIHGIGKLYKCNDC 584

  Fly  1642 EQSEPDSTTTLRQYR----KRGVIVGPQGPL-----HLATPVASPSPSSSPSSSTVDHIPPASPA 1697
            .|...::||....:|    :|.......|..     :||.                 |....|..
Human   585 HQVFSNATTIANHWRIHNEERSYKCNRCGKFFRHRSYLAV-----------------HWRTHSGE 632

  Fly  1698 TPASPAPPPSPAVASTVQVSELRTSHHCLYCEERFTNEISLKKHHQLAHGALTTMPYVCTICKRG 1762
            .|                       :.|..|:|.|:.:.:|::|.::..|   ..||.|..|.:.
Human   633 KP-----------------------YKCEECDEAFSFKSNLQRHRRIHTG---EKPYRCNECGKT 671

  Fly  1763 YRMRTALHRHMESHDVEGRPYECNICRVRFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTESAL 1827
            :..::.|..|...|..| :||:||.|...|.|.|.|.:|| .:|...||:.|:||||.|..:|:|
Human   672 FSRKSYLTCHRRLHTGE-KPYKCNECGKTFGRNSALIIHK-AIHTGEKPYKCNECGKAFSQKSSL 734

  Fly  1828 KTHIKFH-GELGYQCDGCDRTFEYLKELRKHRRTHS-EMFYKCKFCPSSFMRFTNFRAHMKTH 1888
            ..|::.| ||..|:|:.||:.|.....|.||||.|: |..||||.|..:|.|.::...|.:.|
Human   735 TCHLRLHTGEKPYKCEECDKVFSRKSSLEKHRRIHTGEKPYKCKVCDKAFGRDSHLAQHTRIH 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	9/24 (38%)
		C2H2 Zn finger	1396..1416	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1424..1445	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1725..1746	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1756..1776	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1785..1806	CDD:275368	9/20 (45%)
		C2H2 Zn finger	1814..1834	CDD:275368	9/19 (47%)
		zf-C2H2	1839..1861	CDD:278523	10/21 (48%)
		C2H2 Zn finger	1841..1861	CDD:275368	9/19 (47%)
		C2H2 Zn finger	1868..1888	CDD:275368	6/19 (32%)
ZNF845	NP_001308451.1	KRAB	8..>48	CDD:214630
		KRAB	8..47	CDD:279668
		COG5048	169..564	CDD:227381	55/303 (18%)
		C2H2 Zn finger	217..237	CDD:275368
		C2H2 Zn finger	245..265	CDD:275368
		C2H2 Zn finger	273..293	CDD:275368
		C2H2 Zn finger	301..321	CDD:275368
		C2H2 Zn finger	329..349	CDD:275368	9/24 (38%)
		C2H2 Zn finger	357..377	CDD:275368	5/19 (26%)
		zf-H2C2_2	369..394	CDD:290200	7/24 (29%)
		COG5048	381..813	CDD:227381	112/525 (21%)
		C2H2 Zn finger	385..405	CDD:275368	7/20 (35%)
		zf-H2C2_2	397..422	CDD:290200	10/70 (14%)
		C2H2 Zn finger	413..433	CDD:275368	3/19 (16%)
		C2H2 Zn finger	441..461	CDD:275368	2/25 (8%)
		zf-H2C2_2	453..478	CDD:290200	2/29 (7%)
		C2H2 Zn finger	469..489	CDD:275368	2/19 (11%)
		C2H2 Zn finger	497..517	CDD:275368	4/19 (21%)
		zf-H2C2_2	509..534	CDD:290200	3/24 (13%)
		C2H2 Zn finger	525..545	CDD:275368	3/19 (16%)
		zf-H2C2_2	537..560	CDD:290200	3/22 (14%)
		C2H2 Zn finger	553..573	CDD:275368	2/19 (11%)
		C2H2 Zn finger	581..601	CDD:275368	4/19 (21%)
		C2H2 Zn finger	609..629	CDD:275368	4/36 (11%)
		C2H2 Zn finger	637..657	CDD:275368	6/19 (32%)
		zf-H2C2_2	649..674	CDD:290200	7/27 (26%)
		C2H2 Zn finger	665..685	CDD:275368	4/19 (21%)
		C2H2 Zn finger	693..713	CDD:275368	9/20 (45%)
		C2H2 Zn finger	721..741	CDD:275368	9/19 (47%)
		C2H2 Zn finger	749..769	CDD:275368	9/19 (47%)
		zf-H2C2_2	761..786	CDD:290200	13/24 (54%)
		C2H2 Zn finger	777..797	CDD:275368	6/19 (32%)
		C2H2 Zn finger	805..825	CDD:275368
		C2H2 Zn finger	833..853	CDD:275368
		zf-H2C2_2	845..870	CDD:290200
		C2H2 Zn finger	861..881	CDD:275368
		zf-H2C2_2	873..898	CDD:290200
		C2H2 Zn finger	889..909	CDD:275368
		C2H2 Zn finger	917..937	CDD:275368
		C2H2 Zn finger	945..965	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100