DRSC/TRiP Functional Genomics Resources

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Protein Alignment mld and ZNF594

DIOPT Version :9

Sequence 1:NP_001247289.1 Gene:mld / 2768685 FlyBaseID:FBgn0263490 Length:1965 Species:Drosophila melanogaster
Sequence 2:NP_115919.1 Gene:ZNF594 / 84622 HGNCID:29392 Length:807 Species:Homo sapiens


Alignment Length:951 Identity:184/951 - (19%)
Similarity:310/951 - (32%) Gaps:275/951 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly  1067 QMQHQIPPQIEPQIEVQNQEQNTLQLVPQAQHQVVPHVQLQSQLVPHVQTQGTTTTVTYEQIYQQ 1131
            ::|.||..:.| .:|..|.|...|      :|.|.|    ....:.|:.:|.:       .|.:.
Human    23 KLQRQITQECE-LVETSNSEDRLL------KHWVSP----LKDAMRHLPSQES-------GIREM 69

  Fly  1132 HIVQQ-----TVQQSSNKMQVISLPSAGSETTRQWQTQQSQQQQQVQWSSVGGLEAIKSAPVESV 1191
            ||:.|     .:....|:.:.|.  |||..:.|...:.|:.:|:       .||  .:...:.::
Human    70 HIIPQKAIVGEIGHGCNEGEKIL--SAGESSHRYEVSGQNFKQK-------SGL--TEHQKIHNI 123

  Fly  1192 APT------TTTYYISASDLYPQQTETYTMLQPASNESYVIEQ-----------VNHQQQHCQQQ 1239
            ..|      ..|:..|::.:..|:..|       .|:.||..:           :.||:.|..::
Human   124 NKTYECKECEKTFNRSSNLIIHQRIHT-------GNKPYVCNECGKDSNQSSNLIIHQRIHTGKK 181

  Fly  1240 IQMSQQQHQRQHQQQQAQQQQQPIMILIQQPEIQQPVASASNPQQAPL--HIYNAATSNDVHQMQ 1302
            ..:..:..:..:|.....:.:|              :.|..||.:...  ..:..:::..:||..
Human   182 PYICHECGKDFNQSSNLVRHKQ--------------IHSGGNPYECKECGKAFKGSSNLVLHQRI 232

  Fly  1303 HTQRQQIRQQYQHQQYQRLQQPQQTRVVQSHPVLGMPGATSISTKVTPIPVTAARGRPLTLKCRF 1367
            |::.:........:.:.     |.|.::..|         .|.|...|            .:|..
Human   233 HSRGKPYLCNKCGKAFS-----QSTDLIIHH---------RIHTGEKP------------YECYD 271

  Fly  1368 CHNGPRFSSSLEYSRHIID---LHPAVAPFNCPHCPMAFAGRTKRSQHILSHHVVQQYQCGQCSH 1429
            |  |..||.    |.|::.   :|....|..|..|..||...:..::|...|...:.|:|.:|..
Human   272 C--GQMFSQ----SSHLVPHQRIHTGEKPLKCNECEKAFRQHSHLTEHQRLHSGEKPYECHRCGK 330

  Fly  1430 VFPAQKALDVHIQRFHMTLKTDPSGAVKVEDVQLQITSERRPRGRPYKPRLQLQQHQLQPQQKLQ 1494
            .|..:.|...| ||.|        ...|:|:.:...:.:                .:|:.:|:: 
Human   331 TFSGRTAFLKH-QRLH--------AGEKIEECEKTFSKD----------------EELREEQRI- 369

  Fly  1495 VQQHQQQQ--------KALQQLPQAQHHQQQQQPQLQQEVLQQVQQLQVQVQPQQHQQHQQVLQV 1551
               ||:::        :..|.......||.....:...|..:..:...   |.....:|.::...
Human   370 ---HQEEKAYWCNQCGRNFQGTSDLIRHQVTHTGEKPYECKECGKTFN---QSSDLLRHHRIHSG 428

  Fly  1552 QQP-----------QQQPLMQPQSPHPSTVEMQASPTTPRKILCCPDCEDCTSGHSHANEQFEEL 1605
            ::|           ....|::....|           |..|...|.:|....|..||. ...:::
Human   429 EKPCVCSKCGKSFRGSSDLIRHHRVH-----------TGEKPYECSECGKAFSQRSHL-VTHQKI 481

  Fly  1606 QTLQAP------------PTVLTPPSTIVSVPSPQP-----------MVYSQHITMPSPEQSEPD 1647
            .|.:.|            .::|.....|.|...|..           ..:.:|.::.:.|:.|.:
Human   482 HTGEKPYQCTECGKAFRRRSLLIQHRRIHSGEKPYECKECGKLFIWRTAFLKHQSLHTGEKLECE 546

  Fly  1648 STTTLRQYRKRGVIVGPQGPLHLATPVASPSPSSSPSSSTVDHIPPASPATPASPAPPPSPAVAS 1712
            .|     :.:...:.|.|                                               
Human   547 KT-----FSQDEELRGEQ----------------------------------------------- 559

  Fly  1713 TVQVSELRTSHHCLYCEERFTNEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHMESHD 1777
              ::.:...::.|..|...|.....|.: ||:.|  ....||.|..|.:.:...:.|.||...|.
Human   560 --KIHQEAKAYWCNQCGRAFQGSSDLIR-HQVTH--TREKPYECKECGKTFNQSSDLLRHHRIHS 619

  Fly  1778 VEGRPYECNICRVRFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH-GELGYQC 1841
            .| :||.||.|...|...|.|..|. .:|...||:.|.||||.|...|.|.||.|.| ||..|||
Human   620 GE-KPYVCNKCGKSFRGSSDLIKHH-RIHTGEKPYECSECGKAFSQRSHLATHQKIHTGEKPYQC 682

  Fly  1842 DGCDRTFEYLKELRKHRRTHS-EMFYKCKFCPSSFMRFTNFRAHMKTHLPLGVFRNEDAASKSP- 1904
            ..|...|.....|.:|||.|| |..|:||.|...||..|.|..|.:.|....:...|...||.. 
Human   683 SECGNAFRRRSLLIQHRRLHSGEKPYECKECGKLFMWHTAFLKHQRLHAGEKLEECEKTFSKDEE 747

  Fly  1905 --SNNNSH----------------ASSDKLENPATPIEETP 1927
              ....:|                .|||.:.:..|...|.|
Human   748 LRKEQRTHQEKKVYWCNQCSRTFQGSSDLIRHQVTHTREKP 788

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mldNP_001247289.1 zf-AD 186..255 CDD:214871
C2H2 Zn finger 1365..1388 CDD:275368 7/25 (28%)
C2H2 Zn finger 1396..1416 CDD:275368 5/19 (26%)
C2H2 Zn finger 1424..1445 CDD:275368 7/20 (35%)
C2H2 Zn finger 1725..1746 CDD:275368 6/20 (30%)
C2H2 Zn finger 1756..1776 CDD:275368 5/19 (26%)
C2H2 Zn finger 1785..1806 CDD:275368 7/20 (35%)
C2H2 Zn finger 1814..1834 CDD:275368 11/19 (58%)
zf-C2H2 1839..1861 CDD:278523 9/21 (43%)
C2H2 Zn finger 1841..1861 CDD:275368 7/19 (37%)
C2H2 Zn finger 1868..1888 CDD:275368 8/19 (42%)
ZNF594NP_115919.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23 184/951 (19%)
COG5048 96..518 CDD:227381 82/527 (16%)
C2H2 Zn finger 105..121 CDD:275368 4/24 (17%)
C2H2 Zn finger 129..149 CDD:275368 3/19 (16%)
C2H2 Zn finger 157..177 CDD:275368 2/19 (11%)
C2H2 Zn finger 185..205 CDD:275368 2/33 (6%)
C2H2 Zn finger 213..233 CDD:275368 2/19 (11%)
C2H2 Zn finger 241..261 CDD:275368 3/33 (9%)
C2H2 Zn finger 269..289 CDD:275368 7/25 (28%)
C2H2 Zn finger 297..317 CDD:275368 5/19 (26%)
C2H2 Zn finger 325..345 CDD:275368 7/20 (35%)
C2H2 Zn finger 351..370 CDD:275370 3/38 (8%)
COG5048 378..779 CDD:227381 99/474 (21%)
C2H2 Zn finger 378..398 CDD:275368 3/19 (16%)
zf-H2C2_2 390..415 CDD:290200 3/27 (11%)
C2H2 Zn finger 406..426 CDD:275368 2/22 (9%)
C2H2 Zn finger 434..454 CDD:275368 1/19 (5%)
zf-H2C2_2 446..471 CDD:290200 6/35 (17%)
C2H2 Zn finger 462..482 CDD:275368 5/20 (25%)
zf-H2C2_2 474..499 CDD:290200 3/25 (12%)
C2H2 Zn finger 490..510 CDD:275368 1/19 (5%)
C2H2 Zn finger 518..538 CDD:275368 1/19 (5%)
C2H2 Zn finger 570..590 CDD:275368 6/20 (30%)
zf-H2C2_2 582..607 CDD:290200 8/27 (30%)
C2H2 Zn finger 598..618 CDD:275368 5/19 (26%)
zf-H2C2_2 610..633 CDD:290200 10/23 (43%)
C2H2 Zn finger 626..646 CDD:275368 7/20 (35%)
zf-H2C2_2 638..663 CDD:290200 11/25 (44%)
C2H2 Zn finger 654..674 CDD:275368 11/19 (58%)
zf-H2C2_2 666..691 CDD:290200 12/24 (50%)
C2H2 Zn finger 682..702 CDD:275368 7/19 (37%)
C2H2 Zn finger 710..730 CDD:275368 8/19 (42%)
C2H2 Zn finger 736..755 CDD:275368 3/18 (17%)
C2H2 Zn finger 763..783 CDD:275370 3/19 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142330
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24376
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.030

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