Protein Alignment mld and ZNF594

DIOPT Version :10

• Sequence 1: NP_001247289.1
• Gene: mld / 2768685
• FlyBaseID: FBgn0263490
• Length: 1965
• Species: Drosophila melanogaster
• Sequence 2: NP_115919.1
• Gene: ZNF594 / 84622
• HGNCID: 29392
• Length: 807
• Species: Homo sapiens
• Alignment Length: 951
• Identity: 184/951 - (19%)
• Similarity: 310/951 - (32%)
• Gaps: 275/951 - (28%)

  Fly  1067 QMQHQIPPQIEPQIEVQNQEQNTLQLVPQAQHQVVPHVQLQSQLVPHVQTQGTTTTVTYEQIYQQ 1131
            ::|.||..:.| .:|..|.|...|      :|.|.|    ....:.|:.:|.:       .|.:.
Human    23 KLQRQITQECE-LVETSNSEDRLL------KHWVSP----LKDAMRHLPSQES-------GIREM 69

  Fly  1132 HIVQQ-----TVQQSSNKMQVISLPSAGSETTRQWQTQQSQQQQQVQWSSVGGLEAIKSAPVESV 1191
            ||:.|     .:....|:.:.|.  |||..:.|...:.|:.:|:       .||  .:...:.::
Human    70 HIIPQKAIVGEIGHGCNEGEKIL--SAGESSHRYEVSGQNFKQK-------SGL--TEHQKIHNI 123

  Fly  1192 APT------TTTYYISASDLYPQQTETYTMLQPASNESYVIEQ-----------VNHQQQHCQQQ 1239
            ..|      ..|:..|::.:..|:..|       .|:.||..:           :.||:.|..::
Human   124 NKTYECKECEKTFNRSSNLIIHQRIHT-------GNKPYVCNECGKDSNQSSNLIIHQRIHTGKK 181

  Fly  1240 IQMSQQQHQRQHQQQQAQQQQQPIMILIQQPEIQQPVASASNPQQAPL--HIYNAATSNDVHQMQ 1302
            ..:..:..:..:|.....:.:|              :.|..||.:...  ..:..:::..:||..
Human   182 PYICHECGKDFNQSSNLVRHKQ--------------IHSGGNPYECKECGKAFKGSSNLVLHQRI 232

  Fly  1303 HTQRQQIRQQYQHQQYQRLQQPQQTRVVQSHPVLGMPGATSISTKVTPIPVTAARGRPLTLKCRF 1367
            |::.:........:.:.     |.|.::..|         .|.|...|            .:|..
Human   233 HSRGKPYLCNKCGKAFS-----QSTDLIIHH---------RIHTGEKP------------YECYD 271

  Fly  1368 CHNGPRFSSSLEYSRHIID---LHPAVAPFNCPHCPMAFAGRTKRSQHILSHHVVQQYQCGQCSH 1429
            |  |..||.    |.|::.   :|....|..|..|..||...:..::|...|...:.|:|.:|..
Human   272 C--GQMFSQ----SSHLVPHQRIHTGEKPLKCNECEKAFRQHSHLTEHQRLHSGEKPYECHRCGK 330

  Fly  1430 VFPAQKALDVHIQRFHMTLKTDPSGAVKVEDVQLQITSERRPRGRPYKPRLQLQQHQLQPQQKLQ 1494
            .|..:.|...| ||.|        ...|:|:.:...:.:                .:|:.:|::
Human   331 TFSGRTAFLKH-QRLH--------AGEKIEECEKTFSKD----------------EELREEQRI- 369

  Fly  1495 VQQHQQQQ--------KALQQLPQAQHHQQQQQPQLQQEVLQQVQQLQVQVQPQQHQQHQQVLQV 1551
               ||:::        :..|.......||.....:...|..:..:...   |.....:|.::...
Human   370 ---HQEEKAYWCNQCGRNFQGTSDLIRHQVTHTGEKPYECKECGKTFN---QSSDLLRHHRIHSG 428

  Fly  1552 QQP-----------QQQPLMQPQSPHPSTVEMQASPTTPRKILCCPDCEDCTSGHSHANEQFEEL 1605
            ::|           ....|::....|           |..|...|.:|....|..||. ...:::
Human   429 EKPCVCSKCGKSFRGSSDLIRHHRVH-----------TGEKPYECSECGKAFSQRSHL-VTHQKI 481

  Fly  1606 QTLQAP------------PTVLTPPSTIVSVPSPQP-----------MVYSQHITMPSPEQSEPD 1647
            .|.:.|            .::|.....|.|...|..           ..:.:|.::.:.|:.|.:
Human   482 HTGEKPYQCTECGKAFRRRSLLIQHRRIHSGEKPYECKECGKLFIWRTAFLKHQSLHTGEKLECE 546

  Fly  1648 STTTLRQYRKRGVIVGPQGPLHLATPVASPSPSSSPSSSTVDHIPPASPATPASPAPPPSPAVAS 1712
            .|     :.:...:.|.|
Human   547 KT-----FSQDEELRGEQ----------------------------------------------- 559

  Fly  1713 TVQVSELRTSHHCLYCEERFTNEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHMESHD 1777
              ::.:...::.|..|...|.....|.: ||:.|  ....||.|..|.:.:...:.|.||...|.
Human   560 --KIHQEAKAYWCNQCGRAFQGSSDLIR-HQVTH--TREKPYECKECGKTFNQSSDLLRHHRIHS 619

  Fly  1778 VEGRPYECNICRVRFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH-GELGYQC 1841
            .| :||.||.|...|...|.|..|. .:|...||:.|.||||.|...|.|.||.|.| ||..|||
Human   620 GE-KPYVCNKCGKSFRGSSDLIKHH-RIHTGEKPYECSECGKAFSQRSHLATHQKIHTGEKPYQC 682

  Fly  1842 DGCDRTFEYLKELRKHRRTHS-EMFYKCKFCPSSFMRFTNFRAHMKTHLPLGVFRNEDAASKSP- 1904
            ..|...|.....|.:|||.|| |..|:||.|...||..|.|..|.:.|....:...|...||..
Human   683 SECGNAFRRRSLLIQHRRLHSGEKPYECKECGKLFMWHTAFLKHQRLHAGEKLEECEKTFSKDEE 747

  Fly  1905 --SNNNSH----------------ASSDKLENPATPIEETP 1927
              ....:|                .|||.:.:..|...|.|
Human   748 LRKEQRTHQEKKVYWCNQCSRTFQGSSDLIRHQVTHTREKP 788

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		PAT1	<959..>1109	CDD:401645	11/41 (27%)
		C2H2 Zn finger	1365..1388	CDD:275368	7/25 (28%)
		C2H2 Zn finger	1396..1416	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1424..1445	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1725..1746	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1756..1776	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1785..1806	CDD:275368	7/20 (35%)
		zf-C2H2	1812..1834	CDD:395048	11/21 (52%)
		C2H2 Zn finger	1814..1834	CDD:275368	11/19 (58%)
		zf-C2H2	1839..1861	CDD:395048	9/21 (43%)
		C2H2 Zn finger	1841..1861	CDD:275368	7/19 (37%)
		zf-C2H2	1866..1888	CDD:395048	9/21 (43%)
		C2H2 Zn finger	1868..1888	CDD:275368	8/19 (42%)
ZNF594	NP_115919.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		184/951 (19%)
		COG5048	96..518	CDD:227381	82/527 (16%)
		C2H2 Zn finger	105..121	CDD:275368	4/24 (17%)
		C2H2 Zn finger	129..149	CDD:275368	3/19 (16%)
		C2H2 Zn finger	157..177	CDD:275368	2/19 (11%)
		C2H2 Zn finger	185..205	CDD:275368	2/33 (6%)
		C2H2 Zn finger	213..233	CDD:275368	2/19 (11%)
		C2H2 Zn finger	241..261	CDD:275368	3/33 (9%)
		C2H2 Zn finger	269..289	CDD:275368	7/25 (28%)
		C2H2 Zn finger	297..317	CDD:275368	5/19 (26%)
		C2H2 Zn finger	325..345	CDD:275368	7/20 (35%)
		C2H2 Zn finger	351..370	CDD:275370	3/38 (8%)
		C2H2 Zn finger	378..398	CDD:275368	3/19 (16%)
		COG5048	402..791	CDD:227381	99/461 (21%)
		C2H2 Zn finger	406..426	CDD:275368	2/22 (9%)
		C2H2 Zn finger	434..454	CDD:275368	1/19 (5%)
		C2H2 Zn finger	462..482	CDD:275368	5/20 (25%)
		C2H2 Zn finger	490..510	CDD:275368	1/19 (5%)
		C2H2 Zn finger	518..538	CDD:275368	1/19 (5%)
		C2H2 Zn finger	570..590	CDD:275368	6/20 (30%)
		C2H2 Zn finger	598..618	CDD:275368	5/19 (26%)
		C2H2 Zn finger	626..646	CDD:275368	7/20 (35%)
		C2H2 Zn finger	654..674	CDD:275368	11/19 (58%)
		C2H2 Zn finger	682..702	CDD:275368	7/19 (37%)
		C2H2 Zn finger	710..730	CDD:275368	8/19 (42%)
		C2H2 Zn finger	736..755	CDD:275368	3/18 (17%)
		C2H2 Zn finger	763..783	CDD:275370	3/19 (16%)