DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mld and ZNF282

DIOPT Version :9

Sequence 1:NP_001247289.1 Gene:mld / 2768685 FlyBaseID:FBgn0263490 Length:1965 Species:Drosophila melanogaster
Sequence 2:XP_006716214.1 Gene:ZNF282 / 8427 HGNCID:13076 Length:672 Species:Homo sapiens


Alignment Length:497 Identity:121/497 - (24%)
Similarity:181/497 - (36%) Gaps:122/497 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly  1442 QRFHMTLKTDPSGAVKVEDVQLQ--------ITSERRPRGR--PYKPRLQLQQHQLQPQQKLQVQ 1496
            :.:...:..|..|:|...|..:|        :..:|.|..|  |..|  :.....|.|.|....|
Human   229 ENYKTLMSLDAEGSVPKPDAPVQAEPREEPCVWEQRHPEEREIPMDP--EAGAEPLVPAQDASSQ 291

  Fly  1497 QHQQQ------QKALQQLPQAQHHQQQQQPQLQQEVLQQVQQLQVQVQPQQHQQHQQVLQVQQPQ 1555
            ..::.      |:.|::............|...|::|.:::|          ::||.|...|...
Human   292 VKREDTLCVRGQRGLEERAIPTESITVDSPISAQDLLSRIKQ----------EEHQCVWDQQDLA 346

  Fly  1556 QQPLMQPQSPHPSTV------------EMQASPTTPRKILCCPDCE-DCTSGHSHANEQFEELQT 1607
            .:.:  |..|:..::            |.|..|..||..:   |.| ...||.|      :.|..
Human   347 DRDI--PTDPNSESLISAHDILSWIKQEEQPYPWGPRDSM---DGELGLDSGPS------DSLLM 400

  Fly  1608 LQAPPTVLTPPSTIVSVPSPQPMVYSQHITMPSPE-QSEPDSTTTLRQYRKRGVIVGPQGPLHLA 1671
            ::.||.  .||.     |.|||.       .|.|: ||:|.                ||.    .
Human   401 VKNPPP--APPQ-----PQPQPQ-------PPQPQLQSQPQ----------------PQS----L 431

  Fly  1672 TPVA-SPSPSSSPSSSTVDHIPPASPATPASPAPPP-----------------SPAVASTVQVSE 1718
            .|:| :.:|...||...:|......|....|...||                 ..|.|.|     
Human   432 PPIAVAENPGGPPSRGLLDDGFQVLPGERGSGEAPPGGDRSTGGGGGDGGGGGGGAEAGT----- 491

  Fly  1719 LRTSHHCLYCEERFTNEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHMESHDVEGRPY 1783
             .....|..|...     .|:: ..|.||| .:.||.|..|.:.:.:|.:|..|..||..| |||
Human   492 -GAGGGCGSCCPG-----GLRR-SLLLHGA-RSKPYSCPECGKSFGVRKSLIIHHRSHTKE-RPY 547

  Fly  1784 ECNICRVRFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH-GELGYQCDGCDRT 1847
            ||..|...|...|.|..|::| |...:|:.|.||.|.:..:..|:.|.:.| ||..:||..|.::
Human   548 ECAECEKSFNCHSGLIRHQMT-HRGERPYKCSECEKTYSRKEHLQNHQRLHTGERPFQCALCGKS 611

  Fly  1848 FEYLKELRKHRRTHS-EMFYKCKFCPSSFMRFTNFRAHMKTH 1888
            |...:.|.||:|.|: |..|.|..|..||....:.:.|::.|
Human   612 FIRKQNLLKHQRIHTGERPYTCGECGKSFRYKESLKDHLRVH 653

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mldNP_001247289.1 zf-AD 186..255 CDD:214871
C2H2 Zn finger 1365..1388 CDD:275368
C2H2 Zn finger 1396..1416 CDD:275368
C2H2 Zn finger 1424..1445 CDD:275368 0/2 (0%)
C2H2 Zn finger 1725..1746 CDD:275368 4/20 (20%)
C2H2 Zn finger 1756..1776 CDD:275368 5/19 (26%)
C2H2 Zn finger 1785..1806 CDD:275368 7/20 (35%)
C2H2 Zn finger 1814..1834 CDD:275368 6/19 (32%)
zf-C2H2 1839..1861 CDD:278523 8/21 (38%)
C2H2 Zn finger 1841..1861 CDD:275368 7/19 (37%)
C2H2 Zn finger 1868..1888 CDD:275368 5/19 (26%)
ZNF282XP_006716214.1 KRAB 198..260 CDD:214630 5/30 (17%)
KRAB_A-box 198..237 CDD:143639 0/7 (0%)
COG5048 <507..652 CDD:227381 52/148 (35%)
zf-C2H2 519..541 CDD:278523 6/21 (29%)
C2H2 Zn finger 521..541 CDD:275368 5/19 (26%)
zf-H2C2_2 533..558 CDD:290200 12/25 (48%)
C2H2 Zn finger 549..569 CDD:275368 7/20 (35%)
zf-H2C2_2 562..586 CDD:290200 9/24 (38%)
zf-C2H2 575..597 CDD:278523 6/21 (29%)
C2H2 Zn finger 577..597 CDD:275368 6/19 (32%)
zf-H2C2_2 589..614 CDD:290200 9/24 (38%)
C2H2 Zn finger 605..625 CDD:275368 7/19 (37%)
zf-H2C2_2 617..642 CDD:290200 11/24 (46%)
C2H2 Zn finger 633..653 CDD:275368 5/19 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142324
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

Return to query results.
Submit another query.