DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mld and ZNF665

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_001340387.1	Gene:	ZNF665 / 79788	HGNCID:	25885	Length:	706	Species:	Homo sapiens

Alignment Length:	687	Identity:	132/687 - (19%)
Similarity:	227/687 - (33%)	Gaps:	205/687 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1234 QHCQQQIQMSQQQHQRQHQQQQAQQQQQPIMILIQQPEIQQPVASASNPQQAPLHIYNAATSNDV 1298
            :|.:.|:.:|.|.|                     .||:||      ...:..::.||....:..
Human   163 RHIENQLGVSFQSH---------------------LPELQQ------FQHEGKIYEYNQVEKSPN 200

  Fly  1299 HQMQHTQRQQIRQQY-------QHQQYQRLQQPQQTRVVQSHPVLGMPGATSISTKVTPIPVTAA 1356
            ::.:|.:..:..:.:       .|::....::|.|......        |.::.:.:|...|...
Human   201 NRGKHYKCDECGKVFSQNSRLTSHKRIHTGEKPYQCNKCGK--------AFTVRSNLTIHQVIHT 257

  Fly  1357 RGRPLTLKCRFCHNGPRFSSSLEYSRHIIDLHPAVAPFNCPHCPMAFAGRTKRSQHILSHHVVQQ 1421
            ..:|  .||..|  |..||.....:.| ..:|....|:.|..|..||...:|.:.|.:.|...:.
Human   258 GEKP--YKCNEC--GKVFSQPSNLAGH-QRIHTGEKPYKCNECGKAFRAHSKLTTHQVIHTGEKP 317

  Fly  1422 YQCGQCSHVFPAQKALDVHIQRFHMTLKTDPSGAVKVEDVQLQITSERRPR----GRPYKPRLQL 1482
            |:|.:|...|.....|..| :|.|                    |.|:..:    |:.:..|..|
Human   318 YKCKECGKCFTQNSHLASH-RRIH--------------------TGEKPYKCNECGKAFSVRSSL 361

  Fly  1483 QQHQLQPQQKLQVQQHQQQQKALQQLPQAQHHQQQQQPQLQQEVLQQVQQLQVQVQPQQHQQHQQ 1547
            ..||       .:...::..|..:.....:|:...                         .:|::
Human   362 TTHQ-------TIHTGEKPYKCNECGKVFRHNSYL-------------------------AKHRR 394

  Fly  1548 VLQVQQPQQ-QPLMQPQSPHPSTVEMQASPTTPRKILCCPDCEDCTSGHSH-ANEQFEELQTLQA 1610
            :...::|.: ....:..|.|.:..:.|.. .|..|...|.:|....:.:|| ||.:  .:.|.:.
Human   395 IHTGEKPYKCNECGKAFSMHSNLTKHQII-HTGEKPFKCNECVKVFTQYSHLANHR--RIHTGEK 456

  Fly  1611 P------------PTVLTPPSTIVSVPSPQP-----MVYSQHITMPSPEQSEPDSTTTLRQYRKR 1658
            |            .:.||....|.:...|..     .|::|:..:.|                .|
Human   457 PYRCDECGKAFSVRSSLTTHQAIHTGEKPYKCNDCGKVFTQNSHLAS----------------HR 505

  Fly  1659 GVIVGPQGPLHLATPVASPSPSSSPSSSTVDHIPPASPATPASPAPPPSPAVASTVQVSELRTSH 1723
            |:..|.:                                                        .:
Human   506 GIHSGEK--------------------------------------------------------PY 514

  Fly  1724 HCLYCEERFTNEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRHMESHDVEGRPYECNIC 1788
            .|..|.:.|:....|.:|.::..|   ..||.|..|.:.:.:.::|..|...|..: :||:||.|
Human   515 KCDECGKAFSQTSQLARHWRVHTG---EKPYKCNECGKAFSVHSSLTIHQTIHTGQ-KPYKCNDC 575

  Fly  1789 RVRFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH-GELGYQCDGCDRTFEYLK 1852
            ...|...|.|.:|: .:|...||:.|:||||.|...|.|.||...| ||..|:|:.|.:.|....
Human   576 GKVFRHNSYLAIHQ-RIHTGEKPYKCNECGKAFSVHSNLATHQVIHTGEKPYKCNECGKVFTQNS 639

  Fly  1853 ELRKHRRTHS-EMFYKCKFCPSSFMRFTNFRAHMKTH 1888
            .|..|||.|: |..|:|..|..:|...:....||..|
Human   640 HLANHRRIHTGEKPYRCNECGKAFSVRSTLTTHMAVH 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	6/22 (27%)
		C2H2 Zn finger	1396..1416	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1424..1445	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1725..1746	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1756..1776	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1785..1806	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1814..1834	CDD:275368	10/19 (53%)
		zf-C2H2	1839..1861	CDD:278523	8/21 (38%)
		C2H2 Zn finger	1841..1861	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1868..1888	CDD:275368	5/19 (26%)
ZNF665	NP_001340387.1	KRAB	37..76	CDD:307490
		COG5048	192..580	CDD:227381	86/532 (16%)
		C2H2 Zn finger	208..228	CDD:275368	1/19 (5%)
		C2H2 Zn finger	236..256	CDD:275368	3/27 (11%)
		C2H2 Zn finger	264..284	CDD:275368	6/22 (27%)
		C2H2 Zn finger	292..312	CDD:275368	6/19 (32%)
		C2H2 Zn finger	320..340	CDD:275368	6/20 (30%)
		C2H2 Zn finger	348..368	CDD:275368	5/26 (19%)
		C2H2 Zn finger	376..396	CDD:275368	2/44 (5%)
		C2H2 Zn finger	404..424	CDD:275368	3/20 (15%)
		C2H2 Zn finger	432..452	CDD:275368	6/21 (29%)
		C2H2 Zn finger	460..480	CDD:275368	2/19 (11%)
		C2H2 Zn finger	488..508	CDD:275368	5/35 (14%)
		C2H2 Zn finger	516..536	CDD:275368	5/19 (26%)
		C2H2 Zn finger	544..564	CDD:275368	4/19 (21%)
		C2H2 Zn finger	572..592	CDD:275368	7/20 (35%)
		zf-H2C2_2	584..608	CDD:316026	10/24 (42%)
		C2H2 Zn finger	600..620	CDD:275368	10/19 (53%)
		zf-H2C2_2	612..637	CDD:316026	10/24 (42%)
		C2H2 Zn finger	628..648	CDD:275368	7/19 (37%)
		zf-H2C2_2	640..664	CDD:316026	9/23 (39%)
		C2H2 Zn finger	656..676	CDD:275368	5/19 (26%)
		zf-H2C2_2	669..693	CDD:316026	3/8 (38%)
		C2H2 Zn finger	684..704	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142321
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930