DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mld and ZNF226

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_001027544.1	Gene:	ZNF226 / 7769	HGNCID:	13019	Length:	803	Species:	Homo sapiens

Alignment Length:	743	Identity:	141/743 - (18%)
Similarity:	232/743 - (31%)	Gaps:	267/743 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1206 YPQQTETYTMLQPASNESYVIEQVNHQQQHCQQQIQMSQQQ----------HQRQHQQQQAQQQQ 1260
            :|.|..|...:|.:.:|:|::.:.:........:..:.:.|          .||.::.||...:.
Human   130 FPYQVGTELSIQISEDENYIVNKADGPNNTGNPEFPILRTQDSWRKTFLTESQRLNRDQQISIKN 194

  Fly  1261 QPIMILIQQPEIQQPVASASNPQQAPLHIYNAA-------------TSNDVHQMQHTQRQQIRQQ 1312
            :    |.|..:...|:...|:.....:|....:             .:.|.:.|.||.    ::.
Human   195 K----LCQCKKGVDPIGWISHHDGHRVHKSEKSYRPNDYEKDNMKILTFDHNSMIHTG----QKS 251

  Fly  1313 YQHQQ-------------YQRLQQPQQTRVVQSH-------PVLGMPGATSISTKVTPIPVTAAR 1357
            ||..:             :|:||..:::......       |||.:.....:..|
Human   252 YQCNECKKPFSDLSSFDLHQQLQSGEKSLTCVERGKGFCYSPVLPVHQKVHVGEK---------- 306

  Fly  1358 GRPLTLKCRFCHNGPRFSSSLEYSRHIIDLHPAVAPFNCPHCPMAFAGRTKRSQHILSHHVVQQY 1422
                 |||..|  |..||.......| ..:|....|:.|..|...|:.|:..:.|...|...:.|
Human   307 -----LKCDEC--GKEFSQGAHLQTH-QKVHVIEKPYKCKQCGKGFSRRSALNVHCKVHTAEKPY 363

  Fly  1423 QCGQCSHVFPAQKALDVHIQRFHMTLKTDPSGAVKVEDVQLQITSERRPRGRPYKPRLQLQQHQL 1487
            .|.:|...|.....|..| ||.|...|.....|.                |:.:.....||.|
Human   364 NCEECGRAFSQASHLQDH-QRLHTGEKPFKCDAC----------------GKSFSRNSHLQSH-- 409

  Fly  1488 QPQQKLQVQQHQQQQKALQQLPQAQHHQQQQQPQLQQEVLQQVQQLQVQVQPQQHQQ-------- 1544
                                                       |::....:|.:.::
Human   410 -------------------------------------------QRVHTGEKPYKCEECGKGFICS 431

  Fly  1545 -----HQQVLQVQQPQQQPLMQPQSPHPSTVEMQASPTTPRKILCCPDCEDCTSGHSHANEQFEE 1604
                 ||:|...::|.:                               ||:|..|       |..
Human   432 SNLYIHQRVHTGEKPYK-------------------------------CEECGKG-------FSR 458

  Fly  1605 LQTLQAPPTVLTPPSTIVSVPSPQPMVYSQHITMPSPEQSEPDSTTTLRQYRKRGVIVGPQGPLH 1669
            ..:|||...|.|...:.:..      |..:..|:.|..|:.....|..:.|:
Human   459 PSSLQAHQGVHTGEKSYICT------VCGKGFTLSSNLQAHQRVHTGEKPYK------------- 504

  Fly  1670 LATPVASPSPSSSPSSSTVDHIPPASPATPASPAPPPSPAVASTVQVSELRTSHHCLYCEERFTN 1734
                                                                   |..|.:.|..
Human   505 -------------------------------------------------------CNECGKSFRR 514

  Fly  1735 EISLKKHHQLAHGALTT--MPYVCTICKRGYRMRTALHRHMESHDVEGRPYECNICRVRFPRPSQ 1797
                ..|:|: |..:.|  .||.|.||.:|:...:.|..|.::|.:| :|::|..|...|.:.|:
Human   515 ----NSHYQV-HLVVHTGEKPYKCEICGKGFSQSSYLQIHQKAHSIE-KPFKCEECGQGFNQSSR 573

  Fly  1798 LTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH-GELGYQCDGCDRTFEYLKELRKHRRTH 1861
            |.:|:: :|...||:.|:||||.|...:.||.|.:.| ||..|.|:.|.:.|.....|..|:|.|
Human   574 LQIHQL-IHTGEKPYKCEECGKGFSRRADLKIHCRIHTGEKPYNCEECGKVFRQASNLLAHQRVH 637

  Fly  1862 S-EMFYKCKFCPSSFMRFTNFRAHMKTH 1888
            | |..:||:.|..||.|..:.:||.|.|
Human   638 SGEKPFKCEECGKSFGRSAHLQAHQKVH 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	6/22 (27%)
		C2H2 Zn finger	1396..1416	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1424..1445	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1725..1746	CDD:275368	5/20 (25%)
		C2H2 Zn finger	1756..1776	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1785..1806	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1814..1834	CDD:275368	9/19 (47%)
		zf-C2H2	1839..1861	CDD:278523	7/21 (33%)
		C2H2 Zn finger	1841..1861	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1868..1888	CDD:275368	8/19 (42%)
ZNF226	NP_001027544.1	KRAB	8..67	CDD:214630
		C2H2 Zn finger	256..302	CDD:275370	6/45 (13%)
		SUF4-like	306..>357	CDD:411020	16/68 (24%)
		C2H2 Zn finger	309..334	CDD:411020	7/27 (26%)
		C2H2 Zn finger	309..329	CDD:275368	6/22 (27%)
		C2H2 Zn finger	337..357	CDD:411020	5/19 (26%)
		C2H2 Zn finger	337..357	CDD:275368	5/19 (26%)
		COG5048	359..774	CDD:227381	96/488 (20%)
		C2H2 Zn finger	365..385	CDD:275368	7/20 (35%)
		C2H2 Zn finger	393..413	CDD:275368	6/80 (8%)
		C2H2 Zn finger	421..441	CDD:275368	2/19 (11%)
		C2H2 Zn finger	449..469	CDD:275368	8/26 (31%)
		C2H2 Zn finger	477..497	CDD:275368	4/25 (16%)
		C2H2 Zn finger	505..525	CDD:275368	6/24 (25%)
		C2H2 Zn finger	533..553	CDD:275368	6/19 (32%)
		C2H2 Zn finger	561..581	CDD:275368	6/20 (30%)
		C2H2 Zn finger	589..609	CDD:275368	9/19 (47%)
		C2H2 Zn finger	617..637	CDD:275368	6/19 (32%)
		C2H2 Zn finger	645..665	CDD:275368	8/19 (42%)
		C2H2 Zn finger	673..693	CDD:275368
		C2H2 Zn finger	701..721	CDD:275368
		C2H2 Zn finger	729..749	CDD:275368
		C2H2 Zn finger	757..777	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	781..803
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100