DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mld and ZNF225

DIOPT Version :9

Sequence 1:	NP_001247289.1	Gene:	mld / 2768685	FlyBaseID:	FBgn0263490	Length:	1965	Species:	Drosophila melanogaster
Sequence 2:	NP_001308614.1	Gene:	ZNF225 / 7768	HGNCID:	13018	Length:	706	Species:	Homo sapiens

Alignment Length:	856	Identity:	155/856 - (18%)
Similarity:	257/856 - (30%)	Gaps:	315/856 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly  1087 QNTLQLVPQAQHQVVPH-------------VQLQSQLVPHVQTQGTTTTV--TYEQIYQQHIVQQ 1136
            :|.|.:..|:.|:...|             .|.:..|...:|.:..|.:.  |:|.::.    .|
Human    42 RNLLSVGHQSLHRDTFHFLKEEKFWMMETATQREGNLGGKIQMEMETVSESGTHEGLFS----HQ 102

  Fly  1137 TVQQSSNKMQVISLPSAGSETTRQWQTQ----QSQQQQQVQWSSVGGLEAI--KSAPVESVAPTT 1195
            |.:|.|            |:.||...:.    |..:|..:......||..|  :..|.|......
Human   103 TWEQIS------------SDLTRFQDSMVNSFQFSKQDDMPCQVDAGLSIIHVRQKPSEGRTCKK 155

  Fly  1196 TTYYISASDLYPQQTETYTMLQPASNESYVIEQVNHQQQHCQQQIQMSQ--QQHQRQHQQQQAQQ 1258
            :...:|..||:.|       ||  |.|.      :|....|.:....|.  :.|||.|..::...
Human   156 SFSDVSVLDLHQQ-------LQ--SREK------SHTCDECGKSFCYSSALRIHQRVHMGEKLYN 205

  Fly  1259 QQQPIMILIQQPEIQQPVASASNPQQAPLHIYNAATSNDVHQMQHTQRQQIRQQYQHQQYQRLQQ 1323
                              ......:      :|.::...:||..||..:..:.:...:.:.|..
Human   206 ------------------CDVCGKE------FNQSSHLQIHQRIHTGEKPFKCEQCGKGFSRRS- 245

  Fly  1324 PQQTRVVQSHPVLGMPGATSISTKVTPIPVTAARGRPLTLKC--RFCHNGPRFSSSLEYSRHIID 1386
                         |:.....:.|.|.|         .:..||  .|.|:    |...|:.|
Human   246 -------------GLYVHRKLHTGVKP---------HICEKCGKAFIHD----SQLQEHQR---- 280

  Fly  1387 LHPAVAPFNCPHCPMAFAGRTKRSQHILSHHVVQQYQCGQCSHVFPAQKALDVHIQRFHMTLKTD 1451
            :|....||.|..|..:|..|...::|.:.|...:.::|..|...|..:.||:.|
Human   281 IHTGEKPFKCDICCKSFRSRANLNRHSMVHMREKPFRCDTCGKSFGLKSALNSH----------- 334

  Fly  1452 PSGAVKVEDVQLQITSERRPR----GRPYKPRLQLQQHQLQPQQKLQVQQHQQQQKALQQLPQAQ 1512
                      ::..|.|:|.:    |:.:..|..|.:||:.
Human   335 ----------RMVHTGEKRYKCEECGKRFIYRQDLYKHQID------------------------ 365

  Fly  1513 HHQQQQQPQLQQEVLQQVQQLQVQVQPQQHQQHQQVLQVQQPQQQPLMQPQSPHPSTVEMQASPT 1577
             |..::                                              |:
Human   366 -HTGEK----------------------------------------------PY----------- 372

  Fly  1578 TPRKILCCPDCEDCTSGHSHANEQFEELQTLQAPPTVLTPPSTIVSVPSPQPMVYSQHITMPSPE 1642
                     :|::|......|:.                               .|:|:.:.|.|
Human   373 ---------NCKECGKSFRWASG-------------------------------LSRHVRVHSGE 397

  Fly  1643 QSEPDSTTTLRQYRKRGVIVGPQGPLHLATPVASPSPSSSPSSSTVDHIPPASPATPASPAPPPS 1707
                  ||...:...:|...                     :|....|....|...|
Human   398 ------TTFKCEECGKGFYT---------------------NSQRYSHQRAHSGEKP-------- 427

  Fly  1708 PAVASTVQVSELRTSHHCLYCEERFTNEISLKKHHQLAHGALTTMPYVCTICKRGYRMRTALHRH 1772
                           :.|..|.:.:...:.|..|.::..|   ..||.|..|.:.:...:.|..|
Human   428 ---------------YRCEECGKGYKRRLDLDFHQRVHRG---EKPYNCKECGKSFGWASCLLNH 474

  Fly  1773 MESHDVEGRPYECNICRVRFPRPSQLTLHKITVHLLSKPHTCDECGKQFGTESALKTHIKFH-GE 1836
            ...|..| :|::|..|..||.:.|||..|: .||...||..|:||||:|...|.|.:|.:.| |.
Human   475 QRIHSGE-KPFKCEECGKRFTQNSQLYTHR-RVHSGEKPFKCEECGKRFTQNSQLYSHRRVHTGV 537

  Fly  1837 LGYQCDGCDRTFEYLKELRKHRRTHS-EMFYKCKFCPSSFMRFTNFRAHMKTHLPLGVFRNEDAA 1900
            ..|:|:.|.:.|.....|..|:|.|: |..|.||.|..||.|.::...|.:.|.....|:.|:..
Human   538 KPYKCEECGKGFNSKFNLDMHQRVHTGERPYNCKECGKSFSRASSILNHKRLHGDEKPFKCEECG 602

  Fly  1901 SKSPSNNNSHA 1911
            .:...|:..|:
Human   603 KRFTENSQLHS 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mld	NP_001247289.1	zf-AD	186..255	CDD:214871
		C2H2 Zn finger	1365..1388	CDD:275368	6/24 (25%)
		C2H2 Zn finger	1396..1416	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1424..1445	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1725..1746	CDD:275368	4/20 (20%)
		C2H2 Zn finger	1756..1776	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1785..1806	CDD:275368	8/20 (40%)
		C2H2 Zn finger	1814..1834	CDD:275368	9/19 (47%)
		zf-C2H2	1839..1861	CDD:278523	7/21 (33%)
		C2H2 Zn finger	1841..1861	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1868..1888	CDD:275368	7/19 (37%)
ZNF225	NP_001308614.1	KRAB	8..48	CDD:307490	2/5 (40%)
		C2H2 Zn finger	153..170	CDD:275368	4/23 (17%)
		C2H2 Zn finger	178..198	CDD:275368	5/19 (26%)
		COG5048	202..634	CDD:227381	115/665 (17%)
		C2H2 Zn finger	206..226	CDD:275368	3/25 (12%)
		C2H2 Zn finger	234..254	CDD:275368	2/33 (6%)
		C2H2 Zn finger	262..282	CDD:275368	7/27 (26%)
		C2H2 Zn finger	290..310	CDD:275368	5/19 (26%)
		C2H2 Zn finger	318..338	CDD:275368	6/40 (15%)
		C2H2 Zn finger	346..366	CDD:275368	5/44 (11%)
		C2H2 Zn finger	374..394	CDD:275368	5/50 (10%)
		C2H2 Zn finger	402..422	CDD:275368	3/40 (8%)
		C2H2 Zn finger	430..450	CDD:275368	4/19 (21%)
		C2H2 Zn finger	458..478	CDD:275368	4/19 (21%)
		C2H2 Zn finger	486..506	CDD:275368	8/20 (40%)
		C2H2 Zn finger	514..534	CDD:275368	9/19 (47%)
		C2H2 Zn finger	542..562	CDD:275368	6/19 (32%)
		C2H2 Zn finger	570..590	CDD:275368	7/19 (37%)
		C2H2 Zn finger	598..618	CDD:275368	3/16 (19%)
		C2H2 Zn finger	626..646	CDD:275368
		C2H2 Zn finger	654..672	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24376
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100